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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Platelet interactions as therapeutic targets for prevention of atherothrombosis显示文摘 | Smid J Braun Dullaeus R Gawaz M | 2009 | Future Cardiol2009，5，3： | 1 |
| 3 | Experimental research in aerodynamic control with electric and electromagnetic fields显示文摘 | Braun E M Lu F K Wilson D R | 2009 | Progress in Aerospace Sciences2009，45，13： | 1 |
| 4 | Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity显示文摘 | Braun T Schofield PR Sprengel R | 1991 | EMBO J1991，10，7： | 1 |
| 5 | Is hysterosalpingography able to diagnose all uterine malformations correctly? A retrospective study显示文摘 | Braun P Grau F V Prons R M | 2005 | Eur J Radiol2005，53，2： | 1 |
| 6 | Total leucocyte count,but not C-reactive protein,predicts 1-year mortality in patients with acute coronary syndromes treated with percutaneous coronary intervention显示文摘 | Ndrepepa G Braun S Iijima R | | 0，，： | 1 |
| 7 | Stress calculations for assemblies of inelastic spheres in uniform shear 显示文摘 | Walton O R Braun R L | 1985 | Acta Mechanica1985，63，14： | 1 |
| 8 | 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondyliti显示文摘 | Braun J van den Berg R Baraliakos X | 2011 | Ann Rheum Dis2011，70，6： | 1 |
| 9 | Surgical pearl:Dermoscopy of the flee edge of the nail to determine the level of nail plate pigmentation and the location of itsprobable origin in the proximal or distal nail matrix 显示文摘 | Braun RP Baran R Saurat JH | 2006 | J Am Acad Dermatol2006，55，3： | 1 |
| 10 | A molecular phylogeny of the pheasants and partridges suggests that these lineages are not monophyletic显示文摘 | Kimball R T Braun E T Zwartjes P W | 1999 | Mol Phyl Evol1999，11，： | 1 |
| 11 | Skin temperature after interscalene brachial plexus blockade 显示文摘 | Hermanns H Braun S Werdehausen R | 2007 | Reg Anesth Pain Med2007，32，： | 1 |
| 12 | Situs inversus of donor or recipient in liver transplantation 显示文摘 | Braun F Rodeck B Canelo R | 1998 | Transpl lnt1998，11，3： | 1 |
| 13 | Pyrolysis kinetics for lacustrine and marine source rocks by programmed micropyrolysis显示文摘 | Braun R L Burnham A K Reynolds J G | 1991 | Energy & Fuels1991，5，： | 1 |
| 14 | C-reactive protein and atrial fibrillation : 'evidence for the presence of inflammation in the perpetuation of the arrhythmia' 显示文摘 | Acevedo M Corbalan R Braun S | 2006 | Int J Cardiol2006，108，： | 1 |
| 15 | Immunoadsorption onto protein A induces remission in severe systemic lupus erythematosus显示文摘 | Braun N Erley C Klein R | 2000 | Nephrol Dial Transplant2000，15，9： | 1 |
| 16 | Polymeric surfactants from styrene-co-maleic-anhydride copolymers显示文摘 | Braun D Sauerwein R Hellmann G P | 2001 | Macromolecular Symposia2001，163，1： | 1 |
| 17 | Genetically haploid spermatids arephenotypically diploid显示文摘 | BRAUN R E BEHRINGER R R PESCHON J J | 1989 | Nature1989，337，： | 1 |
| 18 | The space-based visible program显示文摘 | Stokes G H von Braun C Sridharan R | 1998 | Lincoln Labortory Journal1998，11，2： | 1 |
| 19 | Enterobacterial hemolysins:activation,secretion and pore formation显示文摘 | Braun V Schonherr R Hobbie S | 1993 | Trends Microbiol1993，1，6： | 1 |
| 20 | Impaired visualworking memory consolidation in schizophrenia 显示文摘 | Fuller R Luck SJ Braun EL | 2009 | Neuropsychology2009，23，： | 1 |
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