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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 3 | Infrared Spectroscopy of LuAlO3:Ce a Useful Tool to Determine Ce Concentration显示文摘 | Zych E Brecher C Lempicki A | 1998 | Spectro Acta A1998，54，11： | 1 |
| 4 | Transfusion medicine:looking to the future显示文摘 | Goodnough LT Shander A Brecher ME | 2003 | Lancet2003，361，9352： | 1 |
| 5 | Development of a dermal cancer slope factor for benzopyrene显示文摘 | Knafla A Phillipps K A Brecher R W | 2006 | Regul Toxicol Pharmacol2006，45，2： | 1 |
| 6 | Suppression of afterglow in CsI:Tl by codoping with Eu2+显示文摘 | BRECHER C LEMPICKI A MILLER S R | 2006 | Nucl Instrum Methods A2006，558，2： | 1 |
| 7 | Transfusion medicine: looking to the future 显示文摘 | Ck:odnough L T Shander A Brecher M E | 2003 | Lancet2003，361，9352： | 1 |
| 8 | Machine tool feed drives 显示文摘 | Altintas Y Verl A Brecher C | 2011 | CIRP Annals--Manufacturing Technol- ogy2011，60，2： | 1 |
| 9 | Machine tool feed drives显示文摘 | Ahintas Y Verl A Brecher C | 2011 | CIRP Arlnals-Manufacturing Technology2011，60，2： | 1 |
| 10 | A new Iutetia-based ceramic scintillator for X-ray imaging显示文摘 | LEMPICKI A BRECHER C SZUPRYCZYNSKI P | 2002 | Nucl Instr Meth A2002，488，3： | 1 |
| 11 | A new lutelia-based ceramic scintillator for X-ray imaging显示文摘 | LEMPICKIA A BRECHER C SZUPRYCZYNSKI P | 2002 | Nucl Instrum Methods Phys Res Sect A2002，488，： | 1 |
| 12 | Short-and long term effects of acetaldehyde on plasma显示文摘 | BRECHER A S ADAMU M T | 2002 | Alcohol2002，26，： | 1 |
| 13 | 显示文摘 | Brecher C Riseberg L A | 1980 | Phys Rev B1980，21，： | 1 |
| 14 | Coagulation Protein Function Ⅵ Augmentation of Anticoagulant Function by Acetaldehyde-Treated Heparin显示文摘 | BRECHER A S HELLMAN K BASISTA M H | 1999 | Digestive Diseases and Sciences1999，44，： | 1 |
| 15 | A new lutetia-bascd ceramic scintillator for X-ray imaging 显示文摘 | LEMPICKI A BRECHER C SZUPRYCZYNSKI P | 2002 | Nucl Instrum Methods2002，488，3： | 1 |
| 16 | Transfusion medicine: looking to the future显示文摘 | Goodnough LT Shander A Brecher ME | 2003 | Lancet2003，361，9352： | 1 |
| 17 | Coagulation protein function: the influence of acetaldehyde-modified heparin on thrombin activity显示文摘 | BRECHER A S FU Q | 1999 | J Investig Med1999，47，： | 1 |
| 18 | Emergency Sever- ity Index Version 4:A valid and reliable tool in pediatric emergency department triage显示文摘 | Green N A Durani Y Brecher D | 2012 | Pediatr Emerg Care2012，28，8： | 1 |
| 19 | Transfusion medicine:looking to the future显示文摘 | Goodnough LT Shander A Brecher ME | 2003 | Lancet2003，361，9352： | 1 |
| 20 | New systematic and time-saving procedure to design cup grinding wheels for the application of ultrasonic assisted grinding显示文摘 | Brecher C Schug R Weber A | 2010 | International Journal of Advanced Manufacturing Technology2010，47，： | 1 |
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