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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 3 | Carotenoids of com and sorghum V显示文摘 | C W B lessin J D Brecher R J Dimler | | 0，，40： | 1 |
| 4 | The importance of long axis ventricular fun-ction 显示文摘 | Brecher S J Stephen J D | 2000 | Heart2000，8，4： | 1 |
| 5 | Thyroid function in pediaric patients after neck irradiation for Hodgkin's disease显示文摘 | Brecher ML Yakar D | 1980 | Med Pediatr Oncol1980，8，2： | 1 |
| 6 | Carotenoids of corn and sorghum V,distribution of xanthophylls and carotenes in hand-dissected and dry2milled fractions of yellow dent corn显示文摘 | Blessin C W Brecher J D Dimler R J | | 0，，40： | 1 |
| 7 | Carotenoids of corn and sorghum V,distribution of xanthophylls and carotenes in hand-dissected and dry2milled fractions of yellow dent corn显示文摘 | Blessin C W Brecher J D Dimler R J | | 0，，40： | 1 |
| 8 | Emergency Sever- ity Index Version 4:A valid and reliable tool in pediatric emergency department triage显示文摘 | Green N A Durani Y Brecher D | 2012 | Pediatr Emerg Care2012，28，8： | 1 |
| 9 | The Emergency Severity Index Version 4 reliability in pediatric patients 显示文摘 | Durani Y Brecher D Walmsley D | 2009 | Pediatr Emerg Care2009，25，11： | 1 |
| 10 | LuAlO3:Ce and other aluminate scintillators显示文摘 | Lempicki A Randles M H Wisniewski D Balcerzky M Brecher C Wojtowiczz A J | 1995 | IEEE Transactions on Nuclear Science1995，42，： | 1 |
| 11 | Carotenoids of corn and sorghum V,distribution of xanthophylls and carotenes in hand dissected and dry2milled fractions of yellow dent corn显示文摘 | Blessin C W Brecher J D Dimler R J | 1963 | Cereal Chem1963，40，： | 1 |
| 12 | Characterization and amino acid sequence of a fatty acid- binding protein from human heart显示文摘 | OFFNER G D BRECHER P SAWLIVICH W B | 1988 | Biochem J1988，252，1： | 1 |
| 13 | The Emergency Severity Index Version 4 : reliability in pediatric patients 显示文摘 | Durani Y Brecher D Walmsley D | 2009 | Pediatr Emerg Care2009，25，8： | 1 |
| 14 | Emergency severity index version 4: a valid and reliable tool in pediatric emergency department triage 显示文摘 | Green NA Durani Y Brecher D | 2012 | Pediatr Emerg Care2012，28，8： | 1 |
| 15 | Carotenoids of corn and sorghum V, Distribution of xanthophylls and carotenes in hand-dissected and dry-milled fractions of yellow dent corn显示文摘 | C W Blessin J D Brecher R J Dimler | 1963 | Cereal Chem1963，40，： | 1 |
| 16 | The primed ebolavirus glycoprotein (19-kilodalton GP1, 2): sequence and residues critical for host cell binding显示文摘 | Dube D Brecher M B Delos S E Rose S C Park E W Schornberg K L | 2009 | J Virol2009，83，： | 1 |
| 17 | Effects of abnormal activation on the time course of the left ventricular pressure pulse in dilated cardiomyophathy显示文摘 | XIAO H B BRECHER S J D GIBSON D G | 1992 | Br Heart J1992，68，： | 1 |
| 18 | Differing effects of right ventricular pacing and left bundle branch block on left ventricular function显示文摘 | XIAO H B BRECHER S J D GIBSON D G | 1993 | Br Heart J1993，69，： | 1 |
| 19 | Nature of ventricular activation in patients with dilated cardiomyopathy:Evidence for bilateral bundle branch block显示文摘 | XIAO H B BRECHER S J D GIBSON D G | 1994 | Br Heart J1994，72，： | 1 |
| 20 | Relationship of an abnormal plasma lipoprotein to protection from atherosclerosis in the cholestero l-fed diabetic Rabbit显示文摘 | Chobanian A V Small D M | 1983 | J Clin Invest1983，72，8： | 1 |
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