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| 1 | Chemotherapy plus percutaneous radiofrequency ablation in patients with inoperable colorectal liver metastases显示文摘AIM:To access the efficacy of chemotherapy plus radiofrequency ablation(RFA)as one line of treatment in inoperable colorectal liver metastases.METHODS:Eligible patients were included in three PhaseⅡstudies.In the first study percutaneous RFA was used first followed by 6 cycles of 5-fluorouracil,leucovorin and irinotecan combination(FOLFIRI)(adjunctive chemotherapy trial).In the other two,chemotherapy(FOLFIRI or 5-fluorouracil,leucovorin and oxaliplatin combination)up to 12 cycles was used first with percutaneous RFA offered to responding patients (primary chemotherapy trials).RESULTS:Thirteen patients were included in the adjunctive chemotherapy trial and 17 in the other two.At inclusion they had 1-4 liver metastases(up to 6.5 cm in size).Two patients died during chemotherapy.All patients in the adjunctive chemotherapy trial and 44%in the primary chemotherapy studies had their metastases ablated.Median PFS and overall survival in the adjunctive study were 13 and 24 mo respectively while in the primary chemotherapy studies they were 10 and 21 mo respectively.Eighty one percent of the patients had tumour relapse in at least one previously ablated lesion.CONCLUSION:Chemotherapy plus RFA in patients with low volume inoperable colorectal liver metastases seems safe and relatively effective.The high local recurrence rate is of concern. | Joseph Sgouros James Cast Krishna K Garadi Maria Belechri David J Breen John RT Monson Anthony Maraveyas | 2011 | World Journal of Gastrointestinal Oncology2011，3，4： | 4 |
| 2 | Clinical Presentation, Investigation, and Management of Pulmonary Vein Stenosis Complicating Ablation for Atrial Fibrillation显示文摘 | Douglas L. Packer Paul Keelan Thomas M. Munger Jerome F. Breen Sam Asirvatham Laura A. Peterson Kristi H. Monahan Mary F. Hauser K Chandrasekaran Lawrence J. Sinak David R. Holmes | 2005 | Circulation2005，，5： | 2 |
| 3 | Quaternary ammonium compounds inhibit and reduce the attachment of viable Salmonella typhimurium to poultry tissues显示文摘 | BREEN P J COMPADRE C M FIFER E K | 1995 | J Food Sci1995，60，6： | 1 |
| 4 | Safety and tolerability of gatifloxacin,an advanced-generation 8-methoxy fluoroquinolone显示文摘 | Breen J Skuba K Grasela D | 1999 | J Resp Dis1999，20，： | 1 |
| 5 | Capillary regression in vascular endothelial growth factor-deficient skeletal muscle显示文摘 | Tang K Breen E C Gerber H P | | 0，，01： | 1 |
| 6 | Skeletal muscle capil- larity during hypoxia: VEGF and its activation 显示文摘 | Breen E Tang K Olfert M | 2008 | High Alt Med Biol2008，9，2： | 1 |
| 7 | Progress in cancer screening over a decade: results of cancer screening from the 1987, 1992, and 1998 Nation- al Health Interview Surveys显示文摘 | Breen N Wagener D K Brown M L | 2001 | J Nail Cancer Inst2001，93，： | 1 |
| 8 | Calcyclin(S100A6) regulates pulmonary fibroblast proliferation,morphology,and cytoskeletal organization in vitro显示文摘 | Breen E Tang K | 2003 | J Cell Biochem2003，88，4： | 1 |
| 9 | Lung-specific inactivation of VEGF in adult mice lends to emphysema-like changes显示文摘 | Tang K Wagner PD Breen EC | 2002 | Am J Respir Crit Care Med2002，165，1： | 1 |
| 10 | The effect of tetracycline on the hepatic secretion of triglyceride显示文摘 | Breen K Schenker S Heimberg M | 1972 | Biochim Biophys Acta1972，270，1： | 1 |
| 11 | Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and Ixeonatal brain injury显示文摘 | Elovitz MA Brown AG Breen K | 2011 | Int J Dev Neurosci2011，29，6： | 1 |
| 12 | Level set modeling and segmentation of diffusion tensor magnetic resonance imaging brain data 显示文摘 | Zhukov L Museth K Breen D | 2003 | Journal of Electronic Imaging2003，12，： | 1 |
| 13 | TNF-alpha-mediated reduction in PGC- 1 alpha may impair skeletal muscle function after cigarette smoke expo- sure显示文摘 | Tang K Wagner PD Breen EC | 2010 | J Cell Physio12010，222，2： | 1 |
| 14 | Clinical Presentation, Investigation, and Management of Pulmonary Vein Stenosis Complicating Ablation for Atrial Fibrillation显示文摘 | Douglas L. Packer Paul Keelan Thomas M. Munger Jerome F. Breen Sam Asirvatham Laura A. Peterson Kristi H. Monahan Mary F. Hauser K Chandrasekaran Lawrence J. Sinak David R. Holmes | 2005 | Circulation2005，，5： | 1 |
| 15 | Intrauterine inflammation, in- sufficient to induce parturition, still evokes fetal and neonatal brain in- jury显示文摘 | Elovitz MA Brown AG Breen K | 2011 | Int J Dev Neurosci2011，29，： | 1 |
| 16 | Potent and persistent in vivo anti HBV activity of chemically modified siRNAs显示文摘 | Morrissey D V Lockridge J A Shaw L Blanchard K Jensen K Breen W | 2005 | Nat Biotechnol2005，23，： | 1 |
| 17 | Photocatalysis of the oxygen reduction reaction at adsorbate-covered silver显示文摘 | McMahon J J Barry M Breen K J | 2008 | Journal of Physical ChemistryC2008，112，4： | 1 |
| 18 | Nitrogen removal in experimental wetland treatment systems : evidence for the role of aquatic plants 显示文摘 | Rogers K H Breen A J Chick A J | 1991 | Research Journal of the Water Pollution Control Federation1991，63，7： | 1 |
| 19 | Nitrogen removal in experimental wetland treatment systems: evidence for the role of aquatic plants显示文摘 | ROGERS K H BREEN A J CHICK A J | 1991 | Research Journal of the Water Pollution Control Federation1991，63，7： | 1 |
| 20 | Epistasis as the prima- ry factor in molecular evolution显示文摘 | Breen M S Kemena C Vlasov P K | 2012 | Nature2012，490，7421： | 1 |
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