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| 1 | Adjuvant chemotherapy for gastric cancer:Current evidence and future challenges显示文摘Gastric cancer still represents one of the major causes of cancer mortality worldwide.Patients survival is mainly related to stage,with a high proportion of patients with metastatic disease at presentation.Thus,the cure rate largely depend upon surgical resection.Despite the additional,albeit small,benefit of adjuvant chemotherapy has been clearly demonstrated,no general consensus has been reached on the best treatment option.Moreover,the narrow therapeutic index of adjuvant chemotherapy(i.e.,limited survival benefit with considerable toxicity)requires a careful assessment of expected risks and benefits for individual patients.Treatment choices vary widely based on the different geographic areas,with chemotherapy alone more often preferred in Europe or Asia and chemoradiotherapy in the United States.In the present review we discuss the current evidence and future challenges regarding adjuvant chemotherapy in curatively resected gastric cancer with particular emphasis on the recently completed landmark studies and meta-analyses.The most recent patient-level meta-analysis demonstrated the benefit of adjuvant chemotherapy over curative surgery;the same Authors also showed that disease free survival may be used as a surrogate end-point for overall survival.We finally discuss future research issues such as the need of economic evaluations,development of prognostic or predictive biomarkers,and the unmet clinical need of trials comparing perioperative chemotherapy with adjuvant treatment. | Rosalba Miceli Gianluca Tomasello Giacomo Bregni Maria Di Bartolomeo Filippo Pietrantonio | 2014 | World Journal of Gastroenterology2014，20，16： | 12 |
| 2 | Nonmyeloablative conditioning followed by hematopoietic cell allografting and donor lymphocyte infusions for patients with metastatic renal and breast cancer显示文摘 | BREGNI M DODERO A PECCATORI J | 2002 | Blood2002，99，11： | 1 |
| 3 | 显示文摘 | Siena S Nicola MD Bregni M | 1995 | Exp Hematol1995，23，14： | 1 |
| 4 | Allogeneic haematopoietic stem cell transplantation for metastatic renal carcinoma in Europe显示文摘 | Barkholt L Bregni M Remberger M | 2006 | Ann Oncol2006，17，7： | 1 |
| 5 | Flow cytometry for clinical estimation of circulating hematopoietic progenitors for autologous tranplantation in cancer patients显示文摘 | Bregni M Brando B | 1991 | Blood1991，77，： | 1 |
| 6 | Comparative effects of granulocyte-macrophage Colony-stimulating Factor and granulocyte Colony-stimulating factor after high-dose cyclophosphamide Cancer therapy显示文摘 | Bregni M Siena S Di Nicola M | 1996 | J Clin Oncol1996，14，： | 1 |
| 7 | Allogeneic haematopoietic stem cell transplantation for metastatic renal carcinoma in Europe显示文摘 | Barkholt L Bregni M Remberger M | 2006 | Ann Oncol2006，17，7： | 1 |
| 8 | Allogeneic stem cell transplantation for metastatic renal cell cancer (RCC)显示文摘 | Bregni M Ciceri F Peecatori J | 2011 | J Cancer2011，2，： | 1 |
| 9 | Nonmyeloablative conditioning followed by hematopoietic cell allografting and donor lymphocyte infusions for patients with metastatic renal and breast cancer显示文摘 | Bregni M Dodero A Peccatori J | 2002 | Blood2002，99，11： | 1 |
| 10 | Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin’s lymphoma显示文摘 | R. Crocchiolo F. Fallanca G. Giovacchini A. J. M. Ferreri A. Assanelli C. Verona A. Pescarollo M. Bregni M. Ponzoni L. Gianolli F. Fazio F. Ciceri | 2009 | Annals of Hematology2009，，12： | 1 |
| 11 | High-dose chemotherapy and autologous bone marrow transplantation compared with MACOP-B in aggressive B-cell lymphoma显示文摘 | Gianni AM Bregni M Siena S | 1997 | N Engl J Med1997，336，： | 1 |
| 12 | Granulocyte-mac-rophage colony-stimulating factor or granulocyte colony-stimulating factor infusion makes high-dose etoposide a safe outpatient regimen that is effective in lymphoma and myeloma patients显示文摘 | Gianni AM Bregni M Siena S | 1992 | J Clin Oncol1992，10，12： | 1 |
| 13 | Better together:targeted combination therapies in breast cancer显示文摘 | Zanardi E Bregni G de Braud F | 2015 | Seminars in Oncology2015，42，6： | 1 |
| 14 | The second international meetting on allogenenic transplantation in solid tumors 显示文摘 | Bregni M Ueno NT Childs R | 2006 | Bone Marrow Transplant2006，38，8： | 1 |
| 15 | Flow cytometry for clinical estimation of circulating haematopoietic progenitors for autologous transplantation in cancer patients显示文摘 | Siena S Bregni M Brando B | 1991 | Blood1991，77，2： | 1 |
| 16 | Nonmyeloablative conditioning followed by hematopoietic cell allografting and donor lymphocyte infusions for patients with metastatic renal and breast cancer显示文摘 | Bregni M Dodero A Peccatori J | 2002 | Blood2002，99，11： | 1 |
| 17 | Massive exvivo generation of functional dendritic cells from mobilized CD34+ blood progenitors for anticancer therapy显示文摘 | Di Nicola M Bregni M | 1995 | Exp Hematol1995，23，： | 1 |
| 18 | Nonmyeloablative con-ditioning followed by hematopoietic cell allografting and donorlymphocyte infusions for patients with metastatic renal andbreast cancer显示文摘 | Bregni M Dodero A Peccatori J | 2002 | Blood2002，99，： | 1 |
| 19 | Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin’s lymphoma显示文摘 | R. Crocchiolo F. Fallanca G. Giovacchini A. J. M. Ferreri A. Assanelli C. Verona A. Pescarollo M. Bregni M. Ponzoni L. Gianolli F. Fazio F. Ciceri | 2009 | Annals of Hematology2009，，12： | 1 |
| 20 | Allogeneic stem cell transplantation for the treatment of advanced solid tumors 显示文摘 | Bregni M Bernardi M Ciceri F | 2004 | Springer Semin Immunopathol2004，26，12： | 1 |
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