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| 1 | IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。 | Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright | 2018 | Cellular & Molecular Immunology2018，15，5： | 17 |
| 2 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 3 | Plant Growth-Promoting Traits in Rhizobacteria of Heavy Metal-Resistant Plants and Their Effects on Brassica nigra Seed Germination显示文摘Phytoremediation is an emerging technology that uses plants and their associated microbes to clean up pollutants from the soil, water, and air. In order to select the plant growth-promoting rhizobacteria(PGPR) for phytoremediation of heavy metal contamination, 60 bacterial strains were isolated from the rhizosphere of two endemic plants, Prosopis laevigata and Spharealcea angustifolia, in a heavy metal-contaminated zone in Mexico. These rhizobacterial strains were characterized for the growth at different pH and salinity, extracellular enzyme production, solubilization of phosphate, heavy metal resistance, and plant growth-promoting(PGP) traits, including production of siderophores and indol-3-acetic acid(IAA). Overall, the obtained rhizobacteria presented multiple PGP traits. These rhizobacteria were also resistant to high levels of heavy metals(including As as a metalloid)(up to 480 mmol L(-1)As(V), 24 mmol L(-1)Pb(Ⅱ), 21 mmol L(-1)Cu(Ⅱ), and 4.5 mmol L(-1)Zn(Ⅱ)). Seven rhizobacterial strains with the best PGP traits were identified as members of Alcaligenes, Bacillus, Curtobacterium, and Microbacterium, and were selected for further bioassay.The inoculation of Brassica nigra seeds with Microbacterium sp. CE3R2, Microbacterium sp. NE1R5, Curtobacterium sp. NM1R1,and Microbacterium sp. NM3E9 facilitated the root development; they significantly improved the B. nigra seed germination and root growth in the presence of heavy metals such as 2.2 mmol L(-1)Zn(Ⅱ). The rhizobacterial strains isolated in the present study had the potential to be used as efficient bioinoculants in phytorremediation of soils contaminated with multiple heavy metals. | Brenda ROMN-PONCE Diana Miryel REZA-VZQUEZ Sonia GUTIRREZ-PAREDES María de Jesús DE HARO-CRUZ Jessica MALDONADO-HERNNDEZ Yanely BAHENA-OSORIO Paulina ESTRADA-DE LOS SANTOS En Tao WANG María Soledad VSQUEZ-MURRIETA | 2017 | Pedosphere2017，27，3： | 4 |
| 4 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 5 | Predictors of survival for esophageal cancer patients with and without celiac axis lymphadenopathy: impact of staging endosonography显示文摘 | Mohamad A Eloubeidi Michael B Wallace Brenda J Hoffman Margaret B Leveen Annette Van Velse Robert H Hawes Carolyn E Reed | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 6 | Facile isolation and the characterization of human retinal stem cells显示文摘 | Brenda LKC Brigitte A Tomoyuki I | 2004 | Proc Natl Acad Sci USA2004，101，15： | 1 |
| 7 | Rencet Advances on the Nutritional Effects Associated with the Use of Garlic as a Supplement显示文摘 | Harunobu A Brenda LP Hiromichi M et a l | 2001 | American Society for Nutritional Sciences2001，35，： | 1 |
| 8 | Modeling singlecomponent protein adsorption to the cation exchange s sepharrosee FF显示文摘 | GRAHAM L S BRENDA J H HOWARD A C | 1990 | Journal of Chromatography A1990，498，： | 1 |
| 9 | Seed bank formation during early secondary succession in a temperate deciduous forest 显示文摘 | Laura A H Brenda B C | 2000 | Journal of Ecology2000，88，： | 1 |
| 10 | Cure studies of interpenetrating networks by microdielectrometry显示文摘 | Brenda S H Craig A T | 1988 | Journal of Applied Polymer Science1988，35，5： | 1 |
| 11 | Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses显示文摘 | Brenda JW Nath N Patricia A | 2002 | Blood2002，100，12： | 1 |
| 12 | Phase I trial of oral green tea extract in adult patientswith solid tumors显示文摘 | Katherine MW Pisters Robert A Newman Brenda Coldman | 2001 | Clinical Oncology2001，19，6： | 1 |
| 13 | Practice guidelines forobstetric anesthesia : an updated report by the American So-ciety of Anesthesiologists Task Force on Obstetric Anesthe-sia and the society for obstetric anesthesia and perinatology显示文摘 | Jeffrey L Joy L Brenda A | 2016 | Anesthesiology2016，124，： | 1 |
| 14 | Health benefits of Bitter Melon(Momordica charantia)显示文摘 | Edralin A L Gerard G D Brenda J S | | 0，，： | 1 |
| 15 | Developmental responses to sowing date in wheat, barley and rapeseed显示文摘 | Daniel J Miralles Brenda C Ferro Gustavo A Slafer | 2001 | Field Crops Research2001，71，： | 1 |
| 16 | Augmentation of an anterior lumbar interbody fusion with an anterior plate or pedicle screw fixation:a comparative biomechanical in vitro study显示文摘 | Tann A Nichols MD Brenda K | | 0，，： | 1 |
| 17 | Vertebral column resection for the treatment of severe spinal deformity 显示文摘 | Lawrence G Lenke MD Brenda A | 2010 | Clin Orthop2010，468，： | 1 |
| 18 | Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism显示文摘 | Timothy A Kimbrell John T Little Robert T Dunn Mark A Frye Benjamin D Greenberg Eric M Wassermann Jennifer D Repella Aimee L Danielson Mark W Willis Brenda E Benson Andrew M Speer Elizabeth Osuch Mark S George Robert M Post | 1999 | Biological Psychiatry1999，，12： | 1 |
| 19 | The conservation-redevelopment dilemma in Singapore:The case of the Kampong Glam historic district显示文摘 | Shirlena Huang | 1996 | Cities1996，，13： | 1 |
| 20 | Large format retailing in the US: a consumer experience perspective显示文摘 | Michelle A Morgan Brenda J Code | 2007 | Journal of Retailing and Consumer Services2007，，7： | 1 |
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