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| 1 | Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss显示文摘In this article,the mechanism of inheritance behind inherited hearing loss and genetic susceptibilityin noise-induced hearing loss are reviewed.Conventional treatments for sensorineural hearing loss(SNHL),i.e.hearing aid and cochlear implant,are effective for some cases,but not without limitations.For example,they provide little benefit for patients of profound SNHL or neural hearing loss,especially when the hearing loss is in poor dynamic range and with low frequency resolution.We emphasize the most recent evidence-based treatment in this field,which includes gene therapy and allotransplantation of stem cells.Their promising results have shown that they might be options of treatment for profound SNHL and neural hearing loss.Although some treatments are still at the experimental stage,it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application. | Yong-qiang Yu Huai-an Yang Ming Xiao Jing-wei Wang Dong-yan Huang Yagesh Bhambhani Lyn Sonnenberg Brenda Clark Yuan-zhe Jin Wei-neng Fu Jie Zhang Qian Yu Xue-ting Liang Ming Zhang | 2015 | Chinese Medical Sciences Journal2015，30，3： | 2 |
| 2 | Pain Sensitization in Male Chronic Pelvic Pain Syndrome: Why Are Symptoms so Difficult to Treat?显示文摘 | CLAIRE C. YANG JAY C. LEE BRENDA G. KROMM MARCIA A. CIOL RICHARD E. BERGER | 2003 | The Journal of Urology2003，，3： | 1 |
| 3 | Screen of Bacillus thuringiensis toxins for transgenic rice to control Sesamia inferens and Chilo suppressalis显示文摘 | Yulin Gao Yang Hu Qiang Fu Jie Zhang Brenda Oppert Fengxiang Lai Yufa Peng Zhitao Zhang | 2010 | Journal of Invertebrate Pathology2010，，1： | 1 |
| 4 | Transcriptional activation of transforming growth factor-β1 in mesangial cell culture by light glucose concentration显示文摘 | Brenda B hoffman KS Yanging Zhu | 1998 | Kidney Int1998，54，4： | 1 |
| 5 | Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis显示文摘 | Li Yang Laura M. DeBusk Koari Fukuda Barbara Fingleton Brenda Green-Jarvis Yu Shyr Lynn M. Matrisian David P. Carbone P.Charles Lin | 2004 | Cancer Cell2004，，： | 1 |
| 6 | 3D microfluidic gradient generator for combination antimicrobial susceptibility testing显示文摘Microfluidic concentration gradient generators(µ-CGGs)have been utilized to identify optimal drug compositions through antimicrobial susceptibility testing(AST)for the treatment of antimicrobial-resistant(AMR)infections.Conventionalµ-CGGs fabricated via photolithography-based micromachining processes,however,are fundamentally limited to two-dimensional fluidic routing,such that only two distinct antimicrobial drugs can be tested at once.This work addresses this limitation by employing Multijet-3D-printed microchannel networks capable of fluidic routing in three dimensions to generate symmetric multidrug concentration gradients.The three-fluid gradient generation characteristics of the fabricated 3Dµ-CGG prototype were quantified through both theoretical simulations and experimental validations.Furthermore,the antimicrobial effects of three highly clinically relevant antibiotic drugs,tetracycline,ciprofloxacin,and amikacin,were evaluated via experimental single-antibiotic minimum inhibitory concentration(MIC)and pairwise and three-way antibiotic combination drug screening(CDS)studies against model antibiotic-resistant Escherichia coli bacteria.As such,this 3Dµ-CGG platform has great potential to enable expedited combination AST screening for various biomedical and diagnostic applications. | Eric Sweet Brenda Yang Joshua Chen Reed Vickerman Yujui Lin Alison Long Eric Jacobs Tinglin Wu Camille Mercier Ryan Jew Yash Attal Siyang Liu Andrew Chang Liwei Lin | 2020 | Microsystems & Nanoengineering2020，6，1： | 1 |
| 7 | Confounding Effect in Clinical Research of Otolaryngology and Its Control显示文摘Confounding effect is a critical issue in clinical research of otolaryngology because it can distort the research's conclusion. In this review, we introduce the definition of confounding effect, the methods of verifying and controlling the effect. Confounding effect can be prevented by research's design, and adjusted by data analysis. Clinicians would be aware and cautious about confounding effect in their research. They would be able to set up a research's design in which appropriate methods have been applied to prevent this effect.They would know how to adjust confounding effect after data collection. It is important to remember that sometimes it is impossible to eliminate confounding effect completely, and statistical method is not a master key. Solid research knowledge and critical thinking of our brain are the most important in controlling confounding effect. | Yong-qiang Yu Dong-yan Huang Susan Armijo Olivo Huai-an Yang Yagesh Bambanini Lyn Sonnenberg Brenda Clark Gabriela Constantinescu Jason Qian Yu Ming Zhang | 2015 | Chinese Medical Sciences Journal2015，30，2： | 0 |
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