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| 1 | Management and prevention of acute and chronic lateral ankle instability in athletic patient populations显示文摘Acute and chronic lateral ankle instability are common in high-demand patient populations. If not managed appropriately, patients may experience recurrent instability, chronic pain, osteochondral lesions of the talus, premature osteoarthritis, and other significantlong-term disability. Certain populations, including young athletes, military personnel and those involved in frequent running, jumping, and cutting motions, are at increased risk. Proposed risk factors include prior ankle sprain, elevated body weight or body mass index, female gender, neuromuscular deficits, postural imbalance, foot/ankle malalignment, and exposure to at-risk athletic activity. Prompt, accurate diagnosis is crucial, and evidence-based, functional rehabilitation regimens have a proven track record in returning active patients to work and sport. When patients fail to improve with physical therapy and external bracing, multiple surgical techniques have been described with reliable results, including both anatomic and nonanatomic reconstructive methods. Anatomic repair of the lateral ligamentous complex remains the gold standard for recurrent ankle instability, and it effectively restores native ankle anatomy and joint kinematics while preserving physiologic ankle and subtalar motion. Further preventative measures may minimize the risk of ankle instability in athletic cohorts, including prophylactic bracing and combined neuromuscular and proprioceptive training programs. These interventions have demonstrated benefit in patients at heightened risk for lateral ankle sprain and allow active cohorts to return to full activity without adversely affecting athletic performance. | Brendan J Mc Criskin Kenneth L Cameron Justin D Orr Brian R Waterman | 2015 | World Journal of Orthopedics2015，6，2： | 20 |
| 2 | Adherence to surveillance endoscopy following hospitalization for index esophageal variceal hemorrhage显示文摘AIM To investigate patient adherence to surveillance endoscopy after index esophageal variceal hemorrhage and the extent to which adherence influences outcomes.METHODS We reviewed the records of patients with cirrhosis admitted to the medical intensive care unit between 2000 and 2014 for first time esophageal variceal hemorrhage treated with endoscopic variceal ligation who were subsequently discharged and scheduled for surveillance endoscopy at our medical center. Demographic and clinical data were obtained through the medical records, including etiology of cirrhosis, completion of variceal obliteration, attendance at surveillance endoscopy, zip code of primary residence, distance from home to hospital, insurance status, rehospitalization for variceal hemorrhage, beta-blocker at discharge, pharmacologically treated psychiatric disorder, and transplant free survival. RESULTS Of 99 consecutive survivors of esophageal variceal bleeding, the minority(33) completed variceal obliteration and fewer(12) adhered to annual surveillance. Completion of variceal obliteration was associated with fewer rehospitalizations for variceal rebleeding(27% vs 56%, P = 0.0099) and when rehospitalizations occurred, they occurred later in those who had completed obliteration(median 259 d vs 207 d, P = 0.0083). Incomplete adherence to endoscopic surveillance was associated with more rehospitalizations for variceal rebleeding compared to those fully adherent to annual endoscopic surveillance(51% vs 17%, P = 0.0328). Those adherent to annual surveillance were more likely to be insured privately or through Medicare compared to those who did not attend post-hospital discharge endoscopy(100% vs 63%, P = 0.0119).CONCLUSION Most patients do not complete variceal obliteration after index esophageal variceal hemorrhage and fewer adhere to endoscopic surveillance, particularly the uninsured and those insured with Medicaid. | Brendan T Everett Steven D Lidofsky | 2018 | World Journal of Gastrointestinal Surgery2018，10，4： | 4 |
| 3 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 4 | Clustering by Passing Messages Between Data Points显示文摘 | Brendan J F Delbert D | 2007 | Science2007，315，16： | 1 |
| 5 | McKay,R(4,5)=25 显示文摘 | Brendan D | 1995 | Journal of Graph Theory1995，19，3： | 1 |
| 6 | An update on the middle levels problem 显示文摘 | Shields Ian Shields Brendan J Savage Carla D | 2009 | Discrete Mathematics2009，309，17： | 1 |
| 7 | The nature of the orthorhombic to tetragonal phase transition in Sr1-x CaxMnO3 显示文摘 | Zhou Q D Brendan J | 2006 | J Solid State Chem2006，179，11： | 1 |
| 8 | The many fac- ets of Notch ligands 显示文摘 | Brendan D souza Alison Miyamoto Gerry Weinmaster | 2008 | Oncogene2008，127，38： | 1 |
| 9 | The nature of the orthorhombic to tetragonal phase transition in Sr1-x CaxMnO3 显示文摘 | Zhou Q D Brendan J Kennedy | 2006 | J Solid State Chem2006，179，11： | 1 |
| 10 | The supercontinent cycle: a retrospective essay 显示文摘 | Nance R D Brendan J M Santosh M | 2014 | Gondwana Research2014，25，1： | 1 |
| 11 | Structured three-dimensional optical phantom for optical coherence tomography 显示文摘 | Curatolo Andrea Kennedy Brendan F Sampson David D | 2011 | Optics Express(S1094-4087)2011，19，19： | 1 |
| 12 | The supercontinent cycle: A retrospective essay显示文摘 | Nance R D Brendan J M Santosh M | 2014 | Gondwana Research2014，25，1： | 1 |
| 13 | Opportunities for harmonic cancellation with carrier-based pwm for two-level and multilevelcascaded inverters显示文摘 | HOLMES D G BRENDAN P | 2001 | IEEE Transactions on Industry Appilcations2001，37，2： | 1 |
| 14 | Clustering by Passing Messages between Data Points显示文摘 | BRENDAN J F DELBERT D | 2007 | Science2007，，315： | 1 |
| 15 | ISBAR for clear communica- tion:one hospital's experience spreading the message显示文摘 | Monica A F Stuart D M Brendan T F | 2010 | Australian Health Review2010，34，4： | 1 |
| 16 | Helicobacter pylori in the pediatric patient 显示文摘 | Brendan D | 1993 | Gastroenterol Clin Noth Am1993，22，2： | 1 |
| 17 | Hypercapnic acidosis at- tenuates severe acute bacterial pneumonia-induced lung injury by a ne- utrophil-independent mechanism 显示文摘 | Martina Ni Chonghaile Brendan D Higgins J | 2008 | Crit Care Med2008，36，12： | 1 |
| 18 | Hierarchical Storage and Visualization of Real-Time 3D Data 显示文摘 | M Robert Parry Brendan Hannigan William Ribarsky Christopher D Shaw and Nickolas Faust | 2001 | SPIE Aerosense2001，4368，： | 1 |
| 19 | Clustering by passing messages between data points显示文摘 | Brendan J F Delbert D | 2007 | Science2007，315，16： | 1 |
| 20 | Thermal expansion and structure of orthorhombi-c Ca Mn O3显示文摘 | Zhou Q Brendan D Kennedy | 2006 | Journal of Physics and Chemistry of Solids2006，67，7： | 1 |
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