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126篇 您的检索式：作者名="Bret L"

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	题名	作者	年代	出处	被引量
1	Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments.	Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen	2019	World Journal of Gastroenterology2019，25，33：	3
2	Bile duct obstruction choledolithiasis:diagnosis with MR cholangiopancreatography显示文摘	Guibaud L Bret PM Reinhold C	1995	Radiology1995，197，1：	1
3	Diagnosis of choledocholithiasis:value of MR cholangiography显示文摘	Guibaud L Bret PM Reinhold C	1994	AJR1994，163，4：	1
4	Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244显示文摘	Bret L Chaibi EB Chanal-Claris C		0，，11：	1
5	Bile duct obstruction and choledocholithiasis:diagnosis with MR cholangiography显示文摘	GUIBAUD L BRET P M REINHOLD C	1995	Radiology1995，187，：	1
6	Chromosomally encoded ampC-type beta-lactamase in aclinical isolate of Proteus mirabilis 显示文摘	Bret L Chanal-Claris C Sitot D	2005	Antimicrobi Agents Chemother2005，42，5：	1
7	Bile duct obstruction and choledocholithiasis:diagnosis with MR cholangiography显示文摘	Guibaud L Bret PM Reinhold C	1995	Radiolog1995，197，1：	1
8	Chromosomally encoded AmpC- typeβ-Lactamase in aclinical isolate of Proteusmirabilis 显示文摘	Bret L Claris C C Sitot D	2005	Antimicrob Agents Chemother2005，42，5：	1
9	Bile duct obstruction and choledocholithiasis: diagnosis with MR cholangiography显示文摘	Guibaud L Bret PM Reinhold C	1995	Radiology1995，197，1：	1
10	Bile duct obstruction and choledocholithiasis;diagnosis with MR cholangiogrphy显示文摘	Guibaud L Bret PM Reinhold C	1995	Radi-ology1995，6，4：	1
11	Bile duct obstruction and choledocholithiasis:diagnosis with MR cholangiography显示文摘	Guibaud L Bret PM Reinhold C	1995	Radiology1995，197，：	1
12	Chromosomally encoded ampC-type beta-lactamase in a clinical isolate of Proteus mirabilis显示文摘	Bret L Chanal-Claris C Sirot D		0，，05：	1
13	Specific activity of class Ⅱ histone deacetylases in human breast cancer cells显示文摘	Duong V Bret C Altucci L		0，，12：	1
14	Diagnosis of choledocholithiasis: value of MR cholangiography显示文摘	Guibaud L Bret PM Renhold C	1994	AJR1994，163，4：	1
15	Bile duct obstruction and choledocholithiasis: diagnosis with MR cholangiography显示文摘	Guibaud L Bret PM Reinhold C	1995	Radi- ology1995，197，1：	1
16	Specific activity of class Ⅱ histone deacetylases in human breast cancer cells显示文摘	Duong V Bret C Aimed L	2008	Mol Cancer Res2008，6，12：	1
17	Bile duct obsturction and choledocholithiasis: diagnosis with MRcholangiography显示文摘	Guibaud L Bret PM Reinhold C	1995	Radiology1995，197，1：	1
18	Bile Duct Obstruction and Choledocholithiasis: Diagnosis with MR Cholangiography 显示文摘	Guiband L Bret PM Reinhold C	1995	Radiology1995，197，1：	1
19	Pale duct obstruction and choledocholithiasis:diagnosis with MR cholangiography显示文摘	Guiband L Bret P M Reihd D C	1995	Radiology1995，97，6：	1
20	Bile duct obstruction and choledocholithiasis: diagnosis with MR cholangiography 显示文摘	Guiband L Bret PM Reinhold C	1995	Radiology1995，197，：	1

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