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| 1 | 每日1次利拉鲁肽与每日2次艾塞那肽治疗2型糖尿病比较:一项为期26周的随机、平行组、多国开放标记试验(LEAD-6)显示文摘背景与大多数抗高血糖药物不同,胰高血糖素样肽-1(GLP-1)受体激动剂的药理作用依赖于葡萄糖水平,并且有助于减轻患者体重。本研究比较了利拉鲁肽(一种人GLP-1类似物)与艾塞那肽(一种基于醋酸艾塞那肽的GLP-1受体激动剂)治疗2型糖尿病的疗效和安全性。方法对于用最大耐受剂量二甲双胍或(和)磺脲仍控制不良的2型糖尿病成年患者,根据之前服用的抗糖尿病药物进行分层,并随机分配这些患者额外接受利拉鲁肽1.8mg每El1次(n=233)或艾塞那肽10μg每日2次(n=231),进行为期26周的开放标记、平行组、多国(15个国家)研究。主要终点是糖化血红蛋白(HbA1c)水平的变化,疗效分析采用意向性治疗分析。本试验在Clinical Trial.gov注册,注册号为NCT00518882。结果受试者的HbA1c平均基线水平为8.2%。与艾塞那肽相比,利拉鲁肽能显著降低HbA1c平均水平[-1.12%(s=0.08%)vs-0.79%(s=0.08%);疗效差异估计值为-0.33%,95%CI-0.47%~-0.18%;P〈0.0001],并且利拉鲁肽组有更多患者HbA1c水平低于7%(54%vs543%;OR 2.02,95%CI 1.31~3.11;P=0.0015)。利拉鲁肽降低平均空腹血糖的能力也显著优于艾塞那肽[-1.61mmol/Lb=0.20)vs-0.60mmol/L(s=0.20);疗效差异估计值为-1.01mmol/L,95%CI-1.37—-0.65;P〈0.0001],但是其降低早餐和晚餐后血糖的能力较艾塞那肽差。两种药物促进患者体重减轻的作用相似(利拉鲁肽组~3.24kg vs艾塞那肽组-2.87地)。耐受性均较好,但与艾塞那肽组相比,利拉鲁肽组患者恶心的持续时间较短(估计的治疗相关事件率比值为0.448,P〈0.0001),轻度低血糖的发生率也较低(每患者每年的事件发生数为1.93vs2.60;发生率比值为0.55,95%C10.34~0.88:P=0.0131;轻度低血糖的发生率为25.5%掷33.6%)。2例同时注射艾塞那肽和一种磺脲类药物的患者发生了严重的低血糖。结论相对于艾塞那肽每日2次,利拉鲁肽每日1次能显著改善血糖控制水平,且患者的耐受性更好。研究结果提示利拉鲁肽或许是2型糖尿病的一种治疗选择,特别是在减轻体重和低血糖风险作为主要考虑因素的情况下。 | John B Buse Julia Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde 赵乐(译) | 2009 | 世界临床医学2009，，11： | 3 |
| 2 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet2009，，9683： | 2 |
| 3 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 4 | System identification of nonlinear state - space models 显示文摘 | T B Schon Adrian Wills Brett Ninness | 2011 | Automatica2011，47，： | 1 |
| 5 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet . 2009 (9683)2009，，9683： | 1 |
| 6 | Targeting the type III secretion system to treat bacterial infections显示文摘 | Marshall N C Brett F B | 2014 | Expert Opinion on Therapeutic Targets2014，18，2： | 1 |
| 7 | Characterisation by EIS of ternary Mg alloys synthesized by mechanical alloying显示文摘 | CHRISTOPHER M A BRETT DIAS L TR1NDADE B FISCHER R M1ES S | 2006 | Electrochimica Acta2006，51，： | 1 |
| 8 | Cooperative distributed model predictive control显示文摘 | Brett T Stewart A N Venkat J B | 2010 | Systems & Control Letters2010，2，59： | 1 |
| 9 | Use of temperature programming to im-prove resolution of inorganic anions,haloacetic acids and oxyhalides in drinking water by suppressed ion chromatography显示文摘 | LEON B BRETT P | 2005 | J Chromatography A2005，1072，2： | 1 |
| 10 | Leung enhancing thoracic lymphadenopathy uncommon etiologies but limited diagnostic considerations 显示文摘 | Micheal B Gotway Brett M | 2005 | Images Pulmonary Medicine2005，12，3： | 1 |
| 11 | An automated handling system for soft compact shaped non-rigid products 显示文摘 | Stone R S Brett P N Evans B S | 1998 | Mechatronics1998，8，2： | 1 |
| 12 | Electrochemical Oxidation of Mn/MnO Films:Formation of an Electrochemical Capacitor显示文摘 | DJURFORS B BROUGHTON J N BRETT M J | 2005 | Acta Materialia2005，53，4： | 1 |
| 13 | Patterns and mechanisms of phytoplankton variability in Lake Washing- ton (USA) 显示文摘 | Arhonditsis G B Winder M Brett M T | 2004 | Water Research2004，38，： | 1 |
| 14 | Magnetostratigraphy susceptibility of the Upper Ordovician Kope Formation, North- ern Kentucky显示文摘 | Ellwood B B Brett C E Macdonald W D | 2007 | Palaeogeography Palaeoclimatology Palaeo- ecology2007，243，12： | 1 |
| 15 | An Automated Han dling System for Soft Compact Shaped Non-rigid Prod- ucts显示文摘 | Stone R S Brett P N Evans B S | 1998 | Mechatronics1998，8，2： | 1 |
| 16 | The emergence of entrepre- neurship policy 显示文摘 | Brett A G David B A Patricia P M | 2004 | Small Business Economics2004，22，34： | 1 |
| 17 | Can innate immunity be enhanced to treat microbial infections 显示文摘 | Brett B Finlay Robert E W Hancock | 2000 | Microbiology2000，2，： | 1 |
| 18 | Defensins in the immunology of bacterial infections显示文摘 | Menendez A Brett Finlay B | 2007 | Curr Opin Immunol2007，19，4： | 1 |
| 19 | Tensor decompositions and applications 显示文摘 | Tamara G K Brett W B | 2009 | SIAM Review2009，51，3： | 1 |
| 20 | Molecular mechanisms of Escherichia colipathogcnicity显示文摘 | Croxen MA Brett B | 2012 | Nat Rev Micmbiol2012，8，1： | 1 |
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