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| 1 | Morinda citrifolia (Noni): A literature review and recent advances in Noni research^1显示文摘Morinda citrifolia L(Noni) has been used in folk remedies by Polynesians for over 2000 years,and is reported to have a broad range of therapeutic effects,including antibacterial,antiviral,antifungal,antitumor,antihelmin,analgesic,hypotensive,anti-inflammatory,and immune enhancing effects.In order to reveal the nutritional and medicinal value of the Noni plant,and to summarize scientific evidence that supports the Polynesians' claim,a literature review and recent advances in Noni research is given below. | Brett J WEST CJarakae JENSEN Diane NOWICKI SU Chen Afa K PALU Gary ANDERSON | 2002 | Acta Pharmacologica Sinica2002，23，12： | 80 |
| 2 | Endoscopic ultrasound evaluation in the surgical treatment of duodenal and peri-ampullary adenomas显示文摘AIM:To investigate endoscopic ultrasound(EUS) for predicting depth of mucosal invasion and to analyze outcomes following endoscopic and transduodenal resection.METHODS:Records of 111 patients seen at our institution from November 1999 to July 2011 with the postoperative pathological diagnosis of benign ampullary and duodenal adenomas were reviewed.Records of patients who underwent preoperative EUS for diagnostic purposes were identified.The accuracy of EUS in predicting the absence of muscular invasion was assessed by comparing EUS reports to the final surgical pathological results.In addition,the incidence of the post-operative complications over a period of 30 d and the subsequent long-term outcome(recurrence) over a period of 30 mo associated with endoscopic and transduodenal surgical resection was recorded,compared and analyzed.RESULTS:Among 111 patients with benign ampullary and duodenal adenomas,47 underwent preoperative EUS for 29 peri-ampullary lesions and 18 duodenal lesions.In addition,computed tomography was performed in 18 patients,endoscopic retrograde cholangio-pancreatography in 10 patients and esophagogastroduodenoscopy in 22 patients.There were 43 patients with sporadic adenomas and 4 patients with familial adenomatous polyposis(FAP)/other polyposis syndromes.In 38(81%,P < 0.05) patients,EUS reliably identified absence of submucosal and muscularis invasion.In 4 cases,EUS underestimated submucosal invasion that was proven by pathology.In the other 5 patients,EUS predicted muscularis invasion which could not be demonstrated in the resected specimen.EUS predicted tumor muscularis invasion with a specificity of 88% and negative predictive value of 90%(P < 0.05).Types of resection performed included endoscopic resection in 22 cases,partial duodenectomy in 9 cases,transduodenal ampullectomy with sphincteroplasty in 10 cases and pancreaticoduodenectomy in 6 cases.The main post-operative final pathological results included villous adenoma(n = 5),adenoma(n = 8),tubulovillous adenoma(n = 10),tubular adenoma(n = 20) and hyperplastic polyp(n = 2).Among the 47 patients who underwent resection,8(17%,5 of which corresponded to surgical resection) developed post-procedural complications which included retroperitoneal hematoma,intra-abdominal abscess,wound infection,delayed gastric emptying and prolonged ileus.After median followup of 20 mo there were 6 local recurrences(13%,median follow-up = 20 mo) 4 of which were in patients with FAP.CONCLUSION:EUS accurately predicts the depth of mucosal invasion in suspected benign ampullary and duodenal adenomas.These patients can safely undergo endoscopic or local resection. | Lilian C Azih Brett L Broussard Milind A Phadnis Martin J Heslin Mohamad A Eloubeidi Shayam Varadarajulu Juan Pablo Arnoletti | 2013 | World Journal of Gastroenterology2013，19，4： | 13 |
| 3 | Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?显示文摘这章探索 capacitation 和 apoptosis 是他们的普通依赖在反应的氧种类(ROS ) 的继续的产生上加入的连接过程的可能性。根据这个模型的意见, capacitation 在当细胞内部的 ROS 产生的后果,刺激细胞内部的营地产生,禁止酷氨酸磷酸酶活动并且由白朊从精子表面在他们的移动以前提高 oxysterols 的形成,跟随他们的版本进女繁殖的道的 spematozoa 被开始。由使能够的 ROS 的继续的产生精子的人口最后压到这些房间的有限能力保护自己免受氧化应力的伤害。作为精子的 over-capacitation 导致的结果,老朽的一个状态和截断的内在的 apoptotic 串联的激活由提高的 mitochondrial ROS 产生,类脂化合物 peroxidation,活动性损失, caspase 激活和 phosphatidylserine 外表表现描绘了。后者可能在指示吞噬细胞的白血球衰老的、垂死的精子的移动应该是由 proinflammatory cytokines 的产生无伴侣的一个沉默过程是特别地重要的。这些观察表明中央角色在定义精子的生活和死亡由氧化还原作用化学玩了。这些机制的知识可以帮助我们设计新奇答案专业化房间高度支持并且保存这些的功能。 | Robert J Aitken Mark A Baker Brett Nixon | 2015 | Asian Journal of Andrology2015，17，4： | 7 |
| 4 | Noni juice is not hepatotoxic显示文摘Noni 果汁(Morinda citrifolia ) 在欧盟以内用作安全食物被同意了,跟随安全的评论。自从赞同,在奥地利人的尖锐肝炎的三个案例非, i 果汁消费者被出版了,在一个原因的连接从植物在肝机能障碍和 anthraquinones 的摄取之间被建议的地方。人的临床的安全地的肝功能的大小 TAHITIAN NONI 果汁学习,以及稍尖并且代替揭示的长期的动物毒性试验不利的肝的证据都不比那些在案例研究报导在多次高的剂量完成。另外, M。citrifolia anthraquinones 在太小而无法具有任何毒物学的意义的数量发生在水果。进一步,这些没有能够被归结为的化学结构反应一个王位激进分子,它在草药的 hepototoxicity 的以前的情况中被含有。可得到的数据不揭示肝毒性的证据。 | Brett J West C Jarakae Jensen Johannes Westendorf | 2006 | World Journal of Gastroenterology2006，12，22： | 5 |
| 5 | Myosin binding protein C:Structural abnormalities in familial hypertrophic cardiomyopathy显示文摘The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insight into the intricate workings of this protein in the heart. While some regions of the MyBPC molecule have been assigned a function in the regulation of muscle contraction, the interaction of other regions with various parts of the myosin molecule and the sarcomeric proteins, actin and titin, remain obscure. In additic n, several intra-domain interactions between adjacent MyBPC molecules have been identified. Although the basic structure of the molecule (a series of immunoglobulin and fibronectin domains) has been elucidated, the assembly of MyBPC in the sarcomere is a topic for debate. By analysing the MyBPC sequence with respect to FHC-causing mutations it is possible to identify individual residues or regions of each domain that may be important either for binding or regulation. This review looks at the current literature, in concert with alignments and the structural models of MyBPC, in an attempt to understand how FHC mutations may lead to the disease state. | Cecily E OAKLEY Brett D HAMBLY Paul MG CURMI Louise J BROWN | 2004 | Cell Research2004，14，2： | 2 |
| 6 | Review: phosphorus removal and recovery technologies 显示文摘 | Morse G K Brett S W Guy J N | 1998 | The Science of the Total Environment1998，212，1： | 1 |
| 7 | Use of the extended trochantcric os- teotomy in treating prosthetic hip infection 显示文摘 | Brett R Levine MD Craig J | 2009 | J Arthroplasty2009，24，： | 1 |
| 8 | Systematic Review of Quality of Life and Other Patient-centred Outcomes after Cardiac Arrest Survival显示文摘 | Elliott V J Rodgers D L Brett S J | 2011 | Resuscitation2011，82，3： | 1 |
| 9 | Coloning and expression of cell surface for advanced glycation end products of proteins 显示文摘 | Neeper M Schemdt AM Brett J | 1992 | J Biol Chem1992，267，14： | 1 |
| 10 | Accessory protein recruitment motifs in clathrin-mediated endocytosis 显示文摘 | BRETT T J TRAUB L M FREMONT D H | 2002 | Structure2002，10，： | 1 |
| 11 | Effect of temperature and feeding regime on the specific growth rate of sockeye salmon(Oncorhynchus nerka)fry,with a consideration of size effect显示文摘 | Shelbourn J E Brett J R Shirahata S | 1973 | Journal of the Fisheries Research Board of Canada1973，30，8： | 1 |
| 12 | An assessment of the total external costs of UK agriculture 显示文摘 | Pretty J N Brett C Gee D | 2000 | Agricultural Systems2000，65，2： | 1 |
| 13 | Mediators, moderators and tests for mediation 显示文摘 | James L R Brett J M | 1984 | Journal of Applied Psychology1984，69，2： | 1 |
| 14 | New materials at a glance 显示文摘 | Brett M J Hawkeye M M | 2008 | Science2008，319，29： | 1 |
| 15 | Simulation of methane autoignition in a rapid compressionmachine with creviced pistons 显示文摘 | BRETT L MACNAMARA J MUSCH P | 2001 | Combustion andFlame2001，124，12： | 1 |
| 16 | Review: Phos- phorus removal and recovery technologies 显示文摘 | Morse G K Brett S W Guy J A | 1998 | The Sci-ence of Total Environment1998，212，： | 1 |
| 17 | A study of explosiveeffects in close proximity to a submerged cylinder显示文摘 | BRETT J M YIANNAKOPOLOUS G | 2008 | International Journal of Impact Engineering2008，35，4： | 1 |
| 18 | Fiehl emission thin1 carbon andsilicon films with pillar microstructure 显示文摘 | Colgan M J and Brett M J | 2001 | Thin Solid Films2001，389，： | 1 |
| 19 | Persistent diurnal rhythmicity in Drosophila emergence 显示文摘 | Brett W J | 1955 | Ann Ent Soc Am1955，48，1： | 1 |
| 20 | Temperature tolerance in young Pacific salmon, genus Oncorhynchus显示文摘 | Brett J R | 1952 | J Fish Res Board Can1952，9，6： | 1 |
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