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	题名	作者	年代	出处	被引量
1	Endoscopic sphincterotomy in patients with stenosis of ampulla of Vater:Three-year follow-up of exocrine pancreatic function and clinical symptoms显示文摘AIM: To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater. METHODS: After diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and ES because of stenosis of the ampulla of Vater (SOD Type Ⅰ), follow-up examinations were performed in 60 patients (mean follow-up time 37.7 mo). Patients were asked about clini-cal signs and symptoms at present and before interven-tion using a standard questionnaire. Before and after ES exocrine pancreatic function was assessed by determina-tion of immunoreactive fecal elastase 1. Serum enzymes indicating cholestasis as well as serum lipase and amy-lase were measured. RESULTS: Eighty percent of patients reported an im-provement in their general condition after ES. The fecal elastase 1 concentrations (FEC) in all patients increased significantly after ES. This effect was even more marked in patients with pathologically low concentrations (< 200 μg/g) of fecal elastase prior to ES. The levels of serum lipase and amylase as well as serum alcaline phosphatase (AP) and gamma-glutamyltranspeptidase (GGT) decreased signifi-cantly after ES. CONCLUSION: The results of this study demonstrate that patients with stenosis of the ampulla of Vater can be successfully treated with endoscopic sphincterotomy. The positive effect is not only indicated by sustained improvement of clinical symptoms and cholestasis but also by improvement of exocrine pancreatic function.	Nils Ewald Axel Michael Marzeion Reinhard Georg Bretzel Hans Ulrich Kloer Philip Daniel Hardt	2007	World Journal of Gastroenterology2007，13，6：	5
2	Diabetes mellitus secondary to pancreatic diseases (Type 3c) — Are we neglecting an important disease?显示文摘	Nils Ewald Reinhard G. Bretzel	2013	European Journal of Internal Medicine2013，，3：	2
3	Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat显示文摘	Gammes HP Lin J Bretzel RG	1998	Diabetes1998，47，11：	1
4	A direct efficay and safety comparsion of insulin aspart,human soluble insulin and human premix insulin (70/30) in patients with type 2 diabetes 显示文摘	Bretzel RG Amolds S Medding J	2004	Diabetes Care2004，，27：	1
5	Equivalence of basal insulin glargine vs prandial insulin lispro for glucose control in type 2 diabetes patients on oral agents-results of the APOLLO study显示文摘	Bretzel RG Linn T	2006	Diabetes2006，55，1：	1
6	Geographic variation of the predictive values of genomic mutations associated with streptomycin resistance in Mycobacterium tuberculosis 显示文摘	Dobner P Bretzel G Rusch-Gerdes S Feldmann K Rifai M Loscher T Rinder H	1997	Mol Cell Probes1997，11，2：	1
7	When basal insulin therapy in type 2 diabetes mellitus is not enough-what next?显示文摘	Raccah D Bretzel RG Owens D	2007	Diabetes Metab Res Rev2007，23，4：	1
8	Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat 显示文摘	Hammes HP Lin J Bretzel RG	1998	Diabetes1998，47，：	1
9	Clinical islet transplantation:guideline for islet quality control显示文摘	Bretzel RG Alejandro R Hering BJ	1994	Transplant Proc1994，26，2：	1
10	2011, Contribution of a municipal solid waste incinerator to the trace metals in the surrounding soil 显示文摘	BRETZEL F CALDERISI M	2011	Environmental Monitoring and Assessment2011，182，1：	1
11	Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat显示文摘	Hammes HP Lin J Bretzel RG	1998	Diabetes1998，47，：	1
12	Insulin-positive cells in vitro generated from rat bone marrow stromal cells 显示文摘	Jahr H Bretzel RG	2003	Transplant Proc2003，35，6：	1
13	Direct Efficacy and Safety Comparison of Insulin Aspart, Human Soluble Insulin, and Human Premix Insulin (70/30) in Patients With Type 2 Diabetes 显示文摘	Reinhard G Bretzel A	2004	Diabetes Care2004，27，5：	1
14	Content and isomoric ratio in food and human Blood Plasma显示文摘	Schiorle J Bretzel W	1997	Food Chem1997，59，3：	1
15	Islet autoantibodies as potential markers for disease recurrence in clinical islet transplantation显示文摘	Jaeger C Brendel MD Eckhard M Bretzel RG		0，，：	1
16	Toxic effects of superoxide, hy- drogen peroxide,and nitric: oxide on human and pig islets显示文摘	JJahr H Bretzel RG Wacker T	1995	Trans- plant Proc1995，27，6：	1
17	The United Kingdom Prospective Diabetes Stady(UKPDS) implications for the pharmacotherapy of type 2diabetes mellitus显示文摘	Bretzel RG Vovigt K Sehatz H	1998	Exp Clin Endocrinol Diabetes1998，106，5：	1
18	Development of a fermentation process for the manufacture of riboflavin显示文摘	Loon V Hohmann H P Bretzel W	1996	Chimia1996，50，：	1
19	A direct efficacy and safetycomparison of insulin aspart, human - soluble inulin, and humanpremix insulin (70/30) in patient swith type 2 diabetes 显示文摘	Bretzel RG Arnolds S Medding J	2004	Diabe-tes Care2004，27，5：	1
20	Protection of islets of langerhans from interleukin-1 toxicity by artificial membranes显示文摘	SIEBERS U BRETZEL R G	1990	Transplantation1990，50，3：	1

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