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| 1 | Antibacterial photodynamic therapy:overview of a promising approach to fight antibiotic-resistant bacterial infections显示文摘Antibacterial photodynamic therapy(APDT)has drawn increasing attention from the scientific society for its potential to effectively kill multidrug-resistant pathogenic bacteria and for its low tendency to induce drug resistance that bacteria can rapidly develop against traditional antibiotic therapy.The review summarizes the mechanism of action of APDT,the photosensitizers,the barriers to PS localization,the targets,the in vitro-,in vivo-,and clinical evidence,the current developments in terms of treating Gram-positive and Gram-negative bacteria,the limitations,as well as future perspectives.Relevance for patients:A structured overview of all important aspects of APDT is provided in the context of resistant bacterial species.The information presented is relevant and accessible for scientists as well as clinicians,whose joint effort is required to ensure that this technology benefits patients in the post-antibiotic era. | Yao Liu Rong Qin Sebastian A.J.Zaat Eefjan Breukink Michal Heger | 2015 | Journal of Clinical & Translational Research2015，1，3： | 8 |
| 2 | Long-term outcome of low perianal fistulas treated by fistulotomy: a multicenter study显示文摘 | K. W. A. G?ttgens P. T. J. Janssen J. Heemskerk F. M. H. Dielen J. L. M. Konsten T. Lettinga A. G. M. Hoofwijk H. J. Belgers L. P. S. Stassen S. O. Breukink | 2015 | International Journal of Colorectal Disease2015，，2： | 2 |
| 3 | Laparoseopic versus open total mesoreetal excision: a case-control study显示文摘 | Breukink SO Pierie JP Grond AJ | 2005 | Int J Colorectal Dis2005，20，5： | 1 |
| 4 | Use of the cell wall precursor lipid Ⅱ by a poreforming peptide antibiotic 显示文摘 | Breukink E Wiedemann I van Kraaij C | 1999 | Science1999，286，5448： | 1 |
| 5 | Laparoscopic versus open total mesorectal excision: a case-control study显示文摘 | Breukink SO Pierie JP Grand A J | 2005 | Int J Colo- rectal Dis2005，20，5： | 1 |
| 6 | The nisin-lipid Ⅱ complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics 显示文摘 | Hsu S T Breukink E Tischenko E | 2004 | Nat Struct Mol Biol2004，11，10： | 1 |
| 7 | Laparoscopic versus open total mesorectal excision:a case-control study显示文摘 | Breukink SO Pierie JP Grond AJ | 2005 | J Colorectal Dis2005，，05： | 1 |
| 8 | Laparoscopic versus open total mesorectal excision:a case-control study显示文摘 | Breukink SO Pierie JP Grond AJ | 2005 | Int J Colorectal Dis2005，20，5： | 1 |
| 9 | The lantibiotic Nisin,a special case or not显示文摘 | BREUKINK E de KRUIJFF B | 1999 | Biochimica et Biophysica Acta1999，1462，： | 1 |
| 10 | Laparoscopic versus open total mesorectal excision:a case-control study显示文摘 | Breukink SO Pierie JP Grond AJ | 2005 | Int J Colorectal Dis2005，20，5： | 1 |
| 11 | Modification and inhi-bition of vancomycin group antibiotics by formaldehyde andacetaldehyde显示文摘 | Heck A Bonnici P Breukink | 2001 | Chem Eur J2001，7，4： | 1 |
| 12 | Relationship between subjective fatigue and physiological variables in patients with chronic obstructive pulmonary disease显示文摘 | Breukink SO Strijbos JH Koorn M | 1998 | Respiratory Medicine1998，92，： | 1 |
| 13 | Laparoscopic versus open total mesorectal excision for rectal cancer显示文摘 | Breukink S Pierie J Wiggers T | 2014 | Co- chrane Database Syst Rev2014，，： | 1 |
| 14 | Laparoscopic versus open total mesorectal excision: a case-control study显示文摘 | S. O. Breukink J. P. E. N. Pierie A. J. K. Grond C. Hoff T. Wiggers W. J. H. J. Meijerink | 2005 | International Journal of Colorectal Disease2005，，5： | 1 |
| 15 | Prospective evaluation of quality of life and sexual functioning after laparoscopic total mesorectal excision显示文摘 | van der Zaag-Loonen HJ Bouma EM | 2007 | Dis Colon Rectum2007，50，2： | 1 |
| 16 | Laparoscopic versus open total mesorectal excision: a case-control study 显示文摘 | Breukink SO Pierie JP Grond AJ | 2005 | Colorectal Dis2005，20，5： | 1 |
| 17 | Laparoscopic versus open total mesorectal excision: a case-control study显示文摘 | S. O. Breukink J. P. E. N. Pierie A. J. K. Grond C. Hoff T. Wiggers W. J. H. J. Meijerink | 2005 | International Journal of Colorectal Disease2005，，5： | 1 |
| 18 | Specific binding of nisin to the peptidoglyean precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity显示文摘 | Wiedemann I Breukink E Kraaij C | 2001 | J Biol Chem2001，276，5： | 1 |
| 19 | Pore formation by nisin involves the translocation of its C-terminal part across the membrane显示文摘 | Van Kraaij C Breukink E Noordermeer M A | 1998 | Biochemistry1998，37，16： | 1 |
| 20 | Chronic central serous chorioretinopathy is associated with genet- ic variants implicated in age-related macular degenera-tion 显示文摘 | de Jong EK Breukink MB Schellevis RL | 2015 | Ophthalmology2015，122，3： | 1 |
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