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| 1 | Traffic Dataset and Dynamic Routing Algorithm in Traffic Simulation显示文摘The purpose of this research is to create a simulated environment for teaching algorithms,big data processing,and machine learning.The environment is similar to Google Maps,with the capacity of finding the fastest path between two points in dynamic traffic situations.However,the system is significantly simplified for educational purposes.Students can choose different traffic patterns and program a car to navigate through the traffic dynamically based on the changing traffic.The environments used in the project are Visual IoT/Robotics Programming Language Environment(VIPLE)and a traffic simulator developed in the Unity game engine.This paper focuses on creating realistic traffic data for the traffic simulator and implementing dynamic routing algorithms in VIPLE.The traffic data are generated from the recorded real traffic data published on the Arizona Maricopa County website.Based on the generated traffic data,VIPLE programs are developed to implement the traffic simulation with support for dynamic changing data. | Zhemin Zhang Gennaro De Luca Brian Archambault Juan MChavez and Brandon Rice | 2022 | Journal of Artificial Intelligence and Technology2022，2，3： | 1 |
| 2 | Sleep after learning aids memory recall 显示文摘 | Steffen Gais Brian Lucas Jan Born | 2006 | Learn Mem2006，13，3： | 1 |
| 3 | Cell-Autonomous Inactivation of the Reelin Pathway Impairs Adult Neurogenesis in the Hippocampus显示文摘 | Catia M. Teixeira Michelle M. Kron Nuria Masachs Helen Zhang Diane C. Lagace Albert Martinez Isabel Reillo Xin Duan Carles Bosch Lluis Pujadas Lucas Brunso Hongjun Song Amelia J. Eisch Victor Borrell Brian W. Howell Jack M. Parent Eduardo Soriano | 2012 | Journal of Neuroscience2012，，35： | 1 |
| 4 | Parent-Dependent Loss of Gene Silencing during Interspecies Hybridization显示文摘 | Caroline Josefsson Brian Dilkes Luca Comai | 2006 | Current Biology2006，，13： | 1 |
| 5 | Aortic Root Replacement in 372 Marfan Patients: Evolution of Operative Repair Over 30 Years显示文摘 | Duke E. Cameron Diane E. Alejo Nishant D. Patel Lois U. Nwakanma Eric S. Weiss Luca A. Vricella Harry C. Dietz Philip J. Spevak Jason A. Williams Brian T. Bethea Torin P. Fitton Vincent L. Gott | 2009 | The Annals of Thoracic Surgery2009，，5： | 1 |
| 6 | The optimization of helper T lymphocyte (HTL) function in vaccine development显示文摘 | Jeff Alexander John Fikes Stephen Hoffman Eileen Franke John Sacci Ettore Appella Francis V. Chisari Luca G. Guidotti Robert W. Chesnut Brian Livingston Dr. Alessandro Sette | 1998 | Immunologic Research1998，，2： | 1 |
| 7 | Preparing patients for hip and knee replacement surgery显示文摘 | Brian Lucas | 2007 | Nursing Stand2007，22，2： | 1 |
| 8 | Preparing patients for hip and knee replace- ment surgery显示文摘 | Brian Lucas | 2007 | Nursing Stand2007，22，2： | 1 |
| 9 | The Use of Locking Plates for Greater Trochanteric Fixation显示文摘 | McGrory Brian J Lucas Romeo | 2009 | Orthopedics (Online)2009，，12： | 1 |
| 10 | Functional and Quality-of-life Outcomes in Patients Undergoing Transperineal Repair with Gracilis Muscle Interposition for Complex Rectourethral Fistula显示文摘 | Mary K. Samplaski Hadley M. Wood Brian R. Lane Feza H. Remzi Armand Lucas Kenneth W. Angermeier | 2011 | Urology2011，，3： | 1 |
| 11 | Preparing patients for hip and knee replacement surgery显示文摘 | Brian Lucas | 2007 | Nursing Stand2007，22，2： | 1 |
| 12 | Microfabricated intracortical extracellular matrix-microelectrodes for improving neural interfaces显示文摘Intracortical neural microelectrodes,which can directly interface with local neural microcircuits with high spatial and temporal resolution,are critical for neuroscience research,emerging clinical applications,and brain computer interfaces(BCI).However,clinical applications of these devices remain limited mostly by their inability to mitigate inflammatory reactions and support dense neuronal survival at their interfaces.Herein we report the development of microelectrodes primarily composed of extracellular matrix(ECM)proteins,which act as a bio-compatible and an electrochemical interface between the microelectrodes and physiological solution.These ECM-microelectrodes are batch fabricated using a novel combination of micro-transfer-molding and excimer laser micromachining to exhibit final dimensions comparable to those of commercial silicon-based microelectrodes.These are further integrated with a removable insertion stent which aids in intracortical implantation.Results from electrochemical models and in vivo recordings from the rat’s cortex indicate that ECM encapsulations have no significant effect on the electrochemical impedance characteristics of ECM-microelectrodes at neurologically relevant frequencies.ECM-microelectrodes are found to support a dense layer of neuronal somata and neurites on the electrode surface with high neuronal viability and exhibited markedly diminished neuroinflammation and glial scarring in early chronic experiments in rats. | Wen Shen Suradip Das Flavia Vitale Andrew Richardson Akshay Ananthakrishnan Laura A.Struzyna Daniel P.Brown Naixin Song Murari Ramkumar Timothy Lucas DKacy Cullen Brian Litt Mark G.Allen | 2018 | Microsystems & Nanoengineering2018，4，1： | 1 |
| 13 | Changing clinical team practices in preparation of patients for Total Knee Replacement: Using Social Cognitive Theory to examine outcomes of an action research study显示文摘 | Brian Lucas Carol Cox Lin Perry et a/ | 2013 | International journal of orthopaedic and trauma nursing2013，17，3： | 1 |
| 14 | Solid Immersion Facilitates Fluorescence Microscopy with Nanometer Resolution and Sub‐?ngstr?m Emitter Localization显示文摘 | Dominik Wildanger Brian R. Patton Heiko Schill Luca Marseglia J. P. Hadden Sebastian Knauer Andreas Sch?nle John G. Rarity Jeremy L. O’Brien Stefan W. Hell Jason M. Smith | 2012 | Adv. Mater2012，，44： | 1 |
| 15 | Expression of a chitinase transgene in rose (Rosa hybrida L.) reduces development of blackspot disease (Diplocarpon rosae Wolf)显示文摘 | Robert Marchant Michael R. Davey John A. Lucas Chris J. Lamb Richard A. Dixon J. Brian Power | 1998 | Molecular Breeding1998，，3： | 1 |
| 16 | Clinical outcomes of cemented distal femur replacements with allpolyethylene tibial components for oncologic indications显示文摘BACKGROUND Endoprosthetic distal femoral replacement(DFR)is a well-established salvage procedure following resection of malignant tumors within the distal femur.Use of an all-polyethylene tibial(APT)component is cost-effective and avoids failure due to locking-mechanism issues and backside wear,but limits modularity and the option for late liner exchange.Due to a paucity of literature we sought to answer three questions:(1)What are the most common modes of implant failure for patients undergoing cemented DFR with APT for oncologic indications?(2)What is the survivorship,rate of all-cause reoperation,and rate of revision for aseptic loosening of these implants?And(3)Is there a difference in implant survivorship or patient demographics between cemented DFRs with APT performed as a primary reconstruction vs those performed as a revision procedure?AIM To assess outcomes of cemented DFRs with APT components used for oncologic indications.METHODS After Institutional Review Board approval,a retrospective review of consecutive patients who underwent DFR between December 2000 to September 2020 was performed using a single-institutional database.Inclusion criteria consisted of all patients who underwent DFR with a GMRS®(Global Modular Replacement System,Stryker,Kalamazoo,MI,United States)cemented distal femoral endoprosthesis and APT component for an oncologic indication.Patients undergoing DFR for non-oncologic indications and patients with metal-backed tibial components were excluded.Implant failure was recorded using Henderson's classification and survivorship was reported using a competing risks analysis.RESULTS 55 DFRs(55 patients)with an average age of 50.9±20.7 years and average body mass index of 29.7±8.3 kg/m2 were followed for 38.8±54.9 mo(range 0.2-208.4).Of these,60.0%were female and 52.7%were white.The majority of DFRs with APT in this cohort were indicated for oncologic diagnoses of osteogenic sarcoma(n=22,40.0%),giant cell tumor(n=9,16.4%),and metastatic carcinoma(n=8,14.6%).DFR with APT implantation was performed as a primary procedure in 29 patients(52.7%)and a revision procedure in 26 patients(47.3%).Overall,twenty patients(36.4%)experienced a postoperative complication requiring reoperation.The primary modes of implant failure included Henderson Type 1(soft tissue failure,n=6,10.9%),Type 2(aseptic loosening,n=5,9.1%),and Type 4(infection,n=6,10.9%).There were no significant differences in patient demographics or rates of postoperative complications between the primary procedure and revision procedure subgroups.In total,12 patients(21.8%)required a revision while 20 patients(36.4%)required a reoperation,resulting in three-year cumulative incidences of 24.0%(95%CI 9.9%-41.4%)and 47.2%(95%CI 27.5%-64.5%),respectively.CONCLUSION This study demonstrates modest short-term survivorship following cemented DFR with APT components for oncologic indications.Soft tissue failure and endoprosthetic infection were the most common postoperative complications in our cohort. | Alexander B Christ Brian C Chung Matthew Urness Lucas W Mayer Brandon S Gettleman Nathanael DHeckmann Lawrence R Menendez | 2023 | World Journal of Orthopedics2023，14，4： | 0 |
| 17 | Anti-cancer effects of aloe-emodin:a systematic review显示文摘Background:Anthraquinones are a possible treatment option for oncological patients due to their anti-cancer properties.Cancer patients often exhaust a plethora of resources that ultimately fail to provide fully curative measures.Alternative treatments are subsequently sought in the hope of finding a therapeutic remedy.Potential regimens include aloe-emodin and its related derivatives.This review therefore summarizes the effects of aloe-emodin and other aloe components in light of their anti-proliferative and anti-carcinogenic properties.Methods:A systematic search was performed in PubMed for aloe-emodin and cancer in humans.Sixty abstracts of in vitro studies were selected and reviewed with subsequent screening of the full text.Thirty-eight articles were summarized.Results:Aloe-emodin possesses multiple anti-proliferative and anti-carcinogenic properties in a host of human cancer cell lines,with often multiple vital pathways affected by the same molecule.The most notable effects include inhibition of cell proliferation,migration,and invasion;cycle arrest;induction of cell death;mitochondrial membrane and redox perturbations;and modulation of immune signaling.The effects of aloe-emodin are not ubiquitous across all cell lines but depend on cell type.Conclusions:On the basis of this systematic review,the multiple consistent effects of aloe-emodin in human-derived cancer cell lines suggest that aloe-emodin is a potential anti-cancer agent that acts on cancer cells in a pleiotropic manner.Relevance for patients:Cancer patients often utilize alternative therapies as a result of suboptimal efficacy of conventional treatments.Aloe-emodin might become a therapeutic option for cancer patients if the basic research is confirmed in clinical trials. | Brian Sanders Anna M.Ray Sharon Goldberg Tyler Clark H.Reginald McDaniel Steven E.Atlas Ashar Farooqi Janet Konefal Lucas C.Lages Johanna Lopez Ammar Rasul Eduard Tiozzo Judi M.Woolger John E.Lewis | 2017 | Journal of Clinical & Translational Research2017，3，3： | 0 |
| 18 | Robotic versus laparoscopic liver resection for huge (≥10 cm) liver tumors: an international multicenter propensity-score matched cohort study of 799 cases显示文摘Background:The use of laparoscopic(LLR)and robotic liver resections(RLR)has been safely performed in many institutions for liver tumours.A large scale international multicenter study would provide stronger evidence and insight into application of these techniques for huge liver tumours≥10 cm.Methods:This was a retrospective review of 971 patients who underwent LLR and RLR for huge(≥10 cm)tumors at 42 international centers between 2002-2020.Results:One hundred RLR and 699 LLR which met study criteria were included.The comparison between the 2 approaches for patients with huge tumors were performed using 1:3 propensity-score matching(PSM)(73 vs.219).Before PSM,LLR was associated with significantly increased frequency of previous abdominal surgery,malignant pathology,liver cirrhosis and increased median blood.After PSM,RLR and LLR was associated with no significant difference in key perioperative outcomes including media operation time(242 vs.290 min,P=0.286),transfusion rate rate(19.2%vs.16.9%,P=0.652),median blood loss(200 vs.300 mL,P=0.694),open conversion rate(8.2%vs.11.0%,P=0.519),morbidity(28.8%vs.21.9%,P=0.221),major morbidity(4.1%vs.9.6%,P=0.152),mortality and postoperative length of stay(6 vs.6 days,P=0.435).Conclusions:RLR and LLR can be performed safely for selected patients with huge liver tumours with excellent outcomes.There was no significant difference in perioperative outcomes after RLR or LLR. | Tan-To Cheung Rong Liu Federica Cipriani Xiaoying Wang Mikhail Efanov David Fuks Gi-Hong Choi Nicholas L.Syn Charing C.N.Chong Fabrizio Di Benedetto Ricardo Robles-Campos Vincenzo Mazzaferro Fernando Rotellar Santiago Lopez-Ben James O.Park Alejandro Mejia Iswanto Sucandy Adrian K.H.Chiow Marco V.Marino Mikel Gastaca Jae Hoon Lee TPeter Kingham Mathieu D’Hondt Sung Hoon Choi Robert P.Sutcliffe Ho-Seong Han Chung-Ngai Tang Johann Pratschke Roberto I.Troisi Go Wakabayashi Daniel Cherqui Felice Giuliante Davit L.Aghayan Bjorn Edwin Olivier Scatton Atsushi Sugioka Tran Cong Duy Long Constantino Fondevila Mohammad Abu Hilal Andrea Ruzzenente Alessandro Ferrero Paulo Herman Kuo-Hsin Chen Luca Aldrighetti Brian K.P.Goh International robotic and laparoscopic liver resection study group investigators | 2023 | Hepatobiliary Surgery and Nutrition2023，12，2： | 0 |
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