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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes显示文摘AIM To establish the impact of portal hypertension(PH) on wait-list/post-transplant outcomes in patients with polycystic liver disease(PCLD) listed for liver transplantation. METHODS A retrospective single-centre case controlled study of consecutive patients listed for liver transplantation over 12 years was performed from our centre. PH in the PCLD cohort was defined by the one or more of following parameters:(1) presence of radiological or endoscopic documented varices from our own centre or the referral centre;(2) splenomegaly(> 11 cm) on radiology inabsence of splenic cysts accounting for increased imaging size;(3) thrombocytopenia(platelets < 150 × 109/L); or(4) ascites without radiological evidence of hepatic venous outflow obstruction from a single cyst. RESULTS Forty-seven PCLD patients(F: M = 42: 5) were listed for liver transplantation(LT)(single organ, n = 35; combined liver-kidney transplantation, n = 12) with 19 patients(40.4%) having PH. When comparing the PH group with non-PH group, the mean listing age(PH group, 50.6(6.4); non-PH group, 47.1(7.4) years; P = 0.101), median listing MELD(PH group, 12; non-PH group, 11; P = 0.422) median listing UKELD score(PH group, 48; non-PH group, 46; P = 0.344) and need for renal replacement therapy(P = 0.317) were similar. In the patients who underwent LT alone, there was no difference in the duration of ICU stay(PH, 3 d; non-PH, 2 d; P = 0.188), hospital stay length(PH, 9 d; non-PH, 10 d; P = 0.973), or frequency of renal replacement therapy(PH, 2/8; non-PH, 1/14; P = 0.121) in the immediate post-transplantation period. CONCLUSION Clinically apparent portal hypertension in patients with PCLD listed for liver transplantation does not appear to have a major impact on wait-list or peri-transplant morbidity. | Neil Rajoriya Dhiraj Tripathi Joanna A Leithead Bridget K Gunson Sophie Lord James W Ferguson Gideon M Hirschfield | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 3 | Paediatric and adult colonic manometry: A tool to help unravel the pathophysiology of constipation显示文摘Colonic motility subserves large bowel functions, including absorption, storage, propulsion and defaecation. Co-lonic motor dysfunction remains the leading hypothesis to explain symptom generation in chronic constipation, a heterogeneous condition which is extremely prevalent in the general population, and has huge socioeconomic impact and individual suffering. Physiological testing plays a crucial role in patient management, as it is now accepted that symptom-based assessment, although im-portant, is unsatisfactory as the sole means of directing therapy. Colonic manometry provides a direct method for studying motor activities of the large bowel, and this review provides a contemporary understanding of how this technique has enhanced our knowledge of normalcolonic motor physiology, as well as helping to elucidate pathophysiological mechanisms underlying constipation. Methodological approaches, including available catheter types, placement technique and recording protocols, are covered, along with a detailed description of re-corded colonic motor activities. This review also criti-cally examines the role of colonic manometry in current clinical practice, and how manometric assessment may aid diagnosis, classification and guide therapeutic inter-vention in the constipated individual. Most importantly, this review considers both adult and paediatric patients. Limitations of the procedure and a look to the future are also addressed. | Philip G Dinning Marc A Benninga Bridget R Southwell S Mark Scott | 2010 | World Journal of Gastroenterology2010，16，41： | 1 |
| 4 | The impact of disease recurrence on graft survival following liver transplantation: a single centre experience显示文摘 | Ian A Rowe Kerry Webb Bridget K Gunson Naimish Mehta Sayeed Haque James Neuberger | 2008 | Transplant International2008，，5： | 1 |
| 5 | Impact of land use and land cover change on groundwater recharge and quality in the southwestern US显示文摘 | Bridget R S Robert C R David A S | | 0，，： | 1 |
| 6 | Increas- ing Observational Learning of Children with Autism:A Pre- liminary Analysis 显示文摘 | Taylor Bridget A Dequinzio Jaime A Stine Jaime | 2012 | Journal of Applied Behavior Analysis2012，，45： | 1 |
| 7 | Prosocial development in early adulthood: A longitudinal study显示文摘 | EISENBERG NANCY GUTHRIE IVANNA K CUMBERLAND AMANDA MURPHY BRIDGET C SHEPARD STEPHANIE A ZHOU QING CARLO GUSTAVO | 2002 | Journal of Personality & Social Psychology2002，82，6： | 1 |
| 8 | Four weeks of cycle training increase basal production of nitric oxide from the forearm 显示文摘 | Kingwell Brownwyn A Bridget Sherrard | 1997 | Am J Physiol1997，272，： | 1 |
| 9 | The biostratigraphy and paleobiology of Oligocene planktonic foraminifera from the equatorial Pacific Ocean (ODP Site 121S) 显示文摘 | Bridget S Wade William A Berggren Richard K Olsson | 2007 | Marine Micropaleontology2007，62，： | 1 |
| 10 | Inpalred FGF signaling contributes to cleft lip and palate显示文摘 | Bridget M Riley M Mansilla A | 2007 | Proc Natl Acad Sci U S A2007，104，11： | 1 |
| 11 | Almond flower development: floral initiation and organogenesis显示文摘 | BRIDGET M L JOSEPH H C ROGER A D | 2001 | Journal of the American Society for Horticultural Science2001，126，6： | 1 |
| 12 | The Importance of Course Design, Feed- back,and Facilitation: Student Perceptions of the Relationship Be- tween Teaching Presence and Cognitive Presence显示文摘 | Hoslera K A Bridget D A | 2012 | Educational Me- dia International2012，49，3： | 1 |
| 13 | Salt selection and simultaneous polymorphism assessment via high-throughput crystallization:the case of sertraline显示文摘 | Julius F Remenar Michael MacPhee J Bridget K Larson Viraj A Tyagi Jason H Ho David A McIlroy Magali B Hickey Paul B Shaw (O)rn Almarsson | | 0，，： | 1 |
| 14 | Vaccination of cattle with Mycobacterium bovines culture Filtrate Proteins andinterleukin-2 for protection against Bovine Tuberculosis显示文摘 | Neil W D Bridget V M A Skinner | 2000 | Infection and Immunity2000，68，： | 1 |
| 15 | Patient and treatment factors associated with complications after prostate brachytherapy显示文摘 | Aileen B Anthony V Bridget A | 2006 | J Clin Oncol2006，24，： | 1 |
| 16 | Targeting the Bcl-2 family for cancer therapy显示文摘 | Shibu Thomas Bridget A Quinn Swadesh K Das Rupesh Dash Luni Emdad Santanu Dasgupta Xiang-Yang Wang Paul Dent John C Reed Maurizio Pellecchia Devanand Sarkar Paul B Fisher | 2013 | Expert Opinion on Therapeutic Targets2013，，1： | 1 |
| 17 | The S2 gene of equine infectious anemia virus is dispensable for viral replication in vitro 显示文摘 | Li F Bridget A Ronald C | 1998 | J Virol1998，72，： | 1 |
| 18 | Targeting the Bcl-2 family for cancer therapy 显示文摘 | Shibu Thomas Bridget A Qui Swadesh K Das | 2012 | Expert Opinion on Therapeutic Targets2012，17，1： | 1 |
| 19 | Targeting the Bcl-2 family for cancer therapy显示文摘 | Shibu Thomas Bridget A Quinn Swadesh K Das Rupesh Dash Luni Emdad Santanu Dasgupta Xiang-Yang Wang Paul Dent John C Reed Maurizio Pellecchia Devanand Sarkar Paul B Fisher | 2013 | Expert Opinion on Therapeutic Targets2013，，1： | 1 |
| 20 | 保乳手术至术后放疗的间隔时间对老年乳腺癌患者局部复发的影响:回顾性队列分析(摘要)显示文摘目的 探讨保乳手术至术后开始放疗的间隔时间长短是否对老年乳腺癌患者局部复发产生影响,以及可能引起放疗推迟的原因。 | Rinaa S Ptmglia Aldko M Saito Bridget A Neville Craig C Earle Jane C Weeks 刘雨桃(译) 王燕(校) | 2010 | 英国医学杂志中文版2010，13，5： | 0 |
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