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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | 人参减少 γ射线照射的淋巴细胞微核量(英文)显示文摘目的 评价中国人参对减少辐射诱导的人周围血 G0 期淋巴细胞 (PBL)微核量的作用。方法 采用细胞因子阻滞的微核法检测健康志愿者的血标本。体外 1 37Cs照射之前 ,每份血标本的单个核细胞培养以不同浓度 (0~ 2 0 0 0μg· m l- 1 )的人参根水提取物孵育 2 4 h。结果 (1)在 0 Gy时 ,每 10 0 0个双核 (BN )细胞的微核量是 11.3± 2 .7,人参水提取物≥ 5 0 0μg· ml- 1 时微核量下降 ,但微核量和人参水提取物的浓度之间的差异是显著的。 (2 )单独射线照射显著增加微核量 ,当暴露于 1Gy的照射时 ,随着培养介质中人参水提取物浓度的增加 ,微核量呈显著的线性降低 (R2 =0 .0 5 ,P =0 .0 0 2 ) ;对暴露于 1Gy辐射诱导的微核量 ,人参水提取物浓度在 15 0 0μg· m l- 1 时减少 4 6 .6 % ,浓度在 2 0 0 0μg·m l- 1时减少 5 7.6 % ;对暴露于 2 Gy辐射诱导的微核量的减少呈更强的线性相关 (R2 =0 .7,P=0 .0 0 0 1) ;(3)微核数据分析的结果呈现出与 Poisson模型相关的过度离散趋势。结果表明 :(1)人参水提取物浓度达 2 0 0 0 μg· ml- 1时 ,对 PBL 细胞毒作用无明显影响 ;(2 )人参水提取物浓度在 5 0 0 μg· ml- 1和 2 0 0 0 μg· ml- 1之间时 ,对抗 1 37Cs照射诱导的 MN发挥保护作用。 | 李同光 Ron R Allison Kevin F O'Brien Prabhaker G Khazanie Larry J Dobbs Jr. Peter J Kragel | 2004 | 新乡医学院学报2004，21，3： | 3 |
| 3 | Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001显示文摘AIM: To evaluate how proximal colon polyps interpreted as hyperplastic polyps in 2001 would be interpreted by expert pathologists in 2007. METHODS: Forty consecutive proximal colon polyps ≥ 5 mm in size, removed in 2001, and originally interpreted as hyperplastic polyps by general pathologists at Indiana University, were reviewed in 2007 by 3 GI pathologists. RESULTS: The gastrointestinal (GI) pathologists interpreted 85%, 43% and 30% of the polyps as sessile serrated polyps (sessile serrated adenomas). The overall Kappa was 0.16. When diagnoses were compared in pairs, Kappa values were 0.38 and 0.25 (fair agreement) and 0.14 (slight agreement). CONCLUSION: Many polyps interpreted as hyperplastic in 2001 were considered sessile serrated lesions by GI pathologists in 2007, but there is substantial inter-observer variation amongst GI pathologists. | Omer Khalid Sofyan Radaideh Oscar W Cummings Michael J O'Brien John R Goldblum Douglas K Rex | 2009 | World Journal of Gastroenterology2009，15，30： | 3 |
| 4 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 5 | An evidence-based review of important issues concerning neonatal hyperbilirubinemia显示文摘 | Ip S Chung M Kulig J O'Brien Sege R Glicken S | 2004 | Pediatrics2004，114，1： | 1 |
| 6 | A surface plasmon resonance array biosensor based on spectroscopic imaging显示文摘 | Michael J O Brien I I Victor H Perez-Luna Brueck S R J | 2001 | Biosensors Bioelectronics2001，16，： | 1 |
| 7 | USPHS tuberculosis short-course chemotherapy trial 21:effectiveness,toxicity and acceptability:report of the final results显示文摘 | Combs D L O'Brien R J Geiter L J | 1990 | Ann Intern Med1990，112，： | 1 |
| 8 | GRIP:a synaptic PDZ domain-containing protein that interacts with AMPA receptors显示文摘 | Dong H O'Brien R J Fung E T | 1997 | Nature1997，386，6622： | 1 |
| 9 | Pre-discharge, but not admission, levels of NT-proBNP predict adverse prognosis following acute LVF 显示文摘 | O' Brien R J Squire IB Demme B | 2003 | Eur J Heart Fail2003，5，4： | 1 |
| 10 | C60:Buckminster- fullerene显示文摘 | Kroto H W Heath J R O'Brien S C | 1985 | Nature1985，318，： | 1 |
| 11 | The Force Exerted bySurface Waves on Piles 显示文摘 | Morison J R O'Brien M P Johnson J W | 1950 | Journal of Petroleum Technology (S0022-3522)1950，2，5： | 1 |
| 12 | Targeted tuberculin tes- ting and treatment of latent tuberculosis infection显示文摘 | Cohn DL O' Brien R J Geiter LJ | 2000 | Am J Respir Crit Care Med2000，161，4： | 1 |
| 13 | The manahement of placenta percreta: con-servative and operative stragtegies 显示文摘 | O'Brien JM Barton J R Donaldson E S | 1996 | Am J Obstet Gynecol1996，175，6： | 1 |
| 14 | Urinary vascular endothelial growth factor and its correlation with bladder cancer recurrence rates显示文摘 | CREW J P O' BRIEN T BICKNELL R | 1999 | J Urol1999，161，3： | 1 |
| 15 | Co-immunotherapy with interleukin-2 and taurolidine for progressive metastatic melanoma 显示文摘 | O'BRIEN G C CAHILL R A BOUCHIER-HAYES D J | 2006 | Ir J Med Sci2006，175，1： | 1 |
| 16 | The Flexible in-Vessel Composting System显示文摘 | O' BRIEN J R | 1997 | Wastes Utilization1997，4，1： | 1 |
| 17 | Novel finding of carbamazepine induced gall bladder granulomatous vasculitis显示文摘 | Haddad R O'Brien B Evans J | 2014 | Intern Med J2014，44，7： | 1 |
| 18 | Vehicle lateral control for automated highway systems 显示文摘 | O'Brien R T Iglesias P A Urban T J | 1996 | IEEE Trans Contr Syst Technol1996，4，3： | 1 |
| 19 | Superoxide anions and endothelial cell proliferation in normoglycemia and hyperglycemia 显示文摘 | Zwacka R Engelhardt J Katusic Z O'Brien T | 2001 | Arterioscler Thromb Vasc Biol2001，21，2： | 1 |
| 20 | C60:Buckminsterfullerene显示文摘 | Kroto H W Heath J R O'Brien S C | 1985 | Nature1985，318，： | 1 |
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