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| 1 | Update on cerebral small vessel disease: a dynamic whole-brain disease显示文摘Cerebral small vessel disease(CSVD)is a very common neurological disease in older people.It causes stroke and dementia,mood disturbance and gait problems.Since it is difficult to visualise CSVD pathologies in vivo,the diagnosis of CSVD has relied on imaging findings including white matter hyperintensities,lacunar ischaemic stroke,lacunes,microbleeds,visible perivascular spaces and many haemorrhagic strokes.However,variations in the use of definition and terms of these features have probably caused confusion and difficulties in interpreting results of previous studies.A standardised use of terms should be encouraged in CSVD research.These CSVD features have long been regarded as different lesions,but emerging evidence has indicated that they might share some common intrinsic microvascular pathologies and therefore,owing to its diffuse nature,CSVD should be regarded as a‘whole-brain disease’.Single antiplatelet(for acute lacunar ischaemic stroke)and management of traditional risk factors still remain the most important therapeutic and preventive approach,due to limited understanding of pathophysiology in CSVD.Increasing evidence suggests that new studies should consider drugs that target endothelium and blood–brain barrier to prevent and treat CSVD.Epidemiology of CSVD might differ in Asian compared with Western populations(where most results and guidelines about CSVD and stroke originate),but more community-based data and clear stratification of stroke types are required to address this. | Yulu Shi Joanna M Wardlaw | 2016 | Stroke & Vascular Neurology2016，1，3： | 74 |
| 2 | The Global Boundary Stratotype Section and Point (GSSP) for the base of Changhsingian Stage (Upper Permian)显示文摘 | Yugan Jin Yue Wang Charles Henderson Bruce R. Wardlaw Shuzhong Shen Changqun Cao | 2006 | Episodes2006，29，3： | 24 |
| 3 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 4 | 改进的WEAP模型在水资源管理中的应用显示文摘在水资源评价和规划模型(WEAP)的基础上耦合多边形网格地下水三维流有限差分模拟系统,建立了WEAP-Tsinghua模型。该模型既能反映各水文测站的径流情况和水资源供需关系与分配,也能反映地下水位动态变化。以石羊河流域为例,建立了该流域的水资源管理模型,并利用2000年用水结构、水文测站径流数据和地下水位观测数据进行参数率定和模型验证,模拟和实测地下水水头差值小于1.0m的观测孔达到总监测点数的50%,模拟和实测蔡旗同金川峡站流量年误差小于1%,模拟的用水结构符合实际,预测分析说明石羊河流域现状用水模式不合理。改进WEAP模型具有友好的用户界面和易于使用的功能,可用于区域水资源规划模拟分析。 | 胡立堂 王忠静 Robin Wardlaw 梁友 | 2009 | 水利学报2009，39，2： | 15 |
| 5 | MRI在腰骶神经根畸形诊断中的价值显示文摘目的确定MRI对腰骶神经根畸形(lumbosacralnerverootanomalies,LNRA)潜在的诊断价值。方法复习376例腰腿痛患者的腰椎MRI片。矢状面及水平面采用T1加权或T2加权成像,冠状面采用短TI反转回复序列成像。结果发现65例存在LNRA,其中分叉神经57例,尾侧起源7例,近邻根1例。手术患者术前诊断的畸形根,在术中显露到的均得到证实。结论MRI特别是短TI反转回复序列冠状面成像能够直观清晰地显示LNRA的起源、路径及大小等信息。 | 王海蛟 Douglas Wardlaw Francis W Smith | 2000 | 中华骨科杂志2000，20，3： | 15 |
| 6 | 颈动脉狭窄:无创伤性检查的准确性——个体病人数据的Meta分析显示文摘目的评价临床相关的无创伤性影像学检查——US、CT血管成像、MR血管成像和MR增强血管成像对于诊断重度和中度有症状的颈动脉狭窄的准确性;确定先期各种特异性临床因素和临床表现对诊断准确性的影响:评估两种无创性检查的一致性。方法利用原始检查资料得到伦理委员会认可。所有的资料都是匿名的。利用个体病例无创性影像学检查的资料(IPDS)评估有症状的颈动脉狭窄的敏感度、特异度和一致性:比较同侧与对侧动脉:比较IPDs与文献的评估结果; | F.M. Chappell J.M. Wardlaw G.R. Young J.H. Gillard G.H. Roditi B. Yip 郑梅竹(译) 夏爽(校) | 2009 | 国际医学放射学杂志2009，32，4： | 12 |
| 7 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 8 | 国际卒中遗传学联盟的推荐意见(第1部分):标准化表型数据收集显示文摘与几乎所有复杂疾病一样,卒中的患病风险和临床转归也是多基因作用的[1]。探索相关基因突变有望为新型个体化治疗方法奠定基础,从而显著减少卒中对全球健康造成的毁灭性影响。为了达到足够的统计学效能以确认多个风险性等位基因,需要很大的样本量。尽管卒中是全世界范围内第二大致死病因和成年人致残的主要原因[2],但没有任何一家研究机构能独立收集到足够的样本。在认识到这一挑战之后,来自世界各地的卒中研究者们于2007年成立了国际卒中遗传学联盟( International Stroke Genetics Consortium, ISGC; http://www. strokegenetics.org),其使命是通过研究在全球多个研究机构入组的患者来识别影响卒中患病风险、临床预后和治疗效果的遗传学因素。尽管先前已取得了一些成功[3-5],仍有大量工作有待进行,这不仅是为了发现风险性等位基因从而达到卒中个体化医疗的最终目标,更是为了开发综合性卒中风险评估手段以及得到足以改变临床实践的结果[6]。根据糖尿病和冠状动脉疾病等其他复杂疾病的研究进展,为了识别与卒中相关的所有基因突变,需要100000~200000个样本。为了达到这个样本量,需要进行更为广泛的协作。 | Jennifer J. Majersik John W.Cole Jonathan Golledge Natalia S. Rost Yu-Feng Yvonne Chan M. Edip Gurol Ame G. Lindgren Daniel Woo Israel Fernandez-Cadenas Donna T. Chen Vincent Thijs Bradford B. Worrall Ayeesha Kamal Paul Bentley Joanna M. Wardlaw Ynte M. Ruigrok Thomas W.K Battey Reinhold Schmidt Joan Montaner Anne-Katrin Giese Jaume Roquer Jordi Jimenez-Conde Chaeyoung Lee Hakan Ay Juan Jose Martin 李海峰 岳耀先 徐军 | 2015 | 国际脑血管病杂志2015，23，9： | 3 |
| 9 | Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes显示文摘 | Eric J. Kunkel Judie Boisvert Kristine Murphy Mark A. Vierra Mark C. Genovese Andrew J. Wardlaw Harry B. Greenberg Martin R. Hodge Lijun Wu Eugene C. Butcher James J. Campbell | 2002 | The American Journal of Pathology2002，，1： | 2 |
| 10 | 脑小血管病:犹如“风暴”过后的全脑灾难显示文摘脑小血管病(cerebral small vessel d isease,CSVD)是一种临床及影像综合征,病变累及脑的穿通小动脉、毛细血管及小静脉,临床表现为卒中、痴呆、情感障碍及步态异常,影像学表现为近期皮层下梗死及微梗死灶、腔隙灶、白质高信号(white matter hyperintensitie,WMH)、微出血及出血灶、血管周围间隙扩大及脑萎缩。 | YULU SHI JOANNA M WARDLAW 李伟 | 2017 | 中国卒中杂志2017，12，11： | 2 |
| 11 | 急性缺血性脑卒中不同药物、剂量、给药途径溶栓治疗效果的系统评价显示文摘目的 评价不同药物、剂量、给药途径(静脉或动脉)的溶栓疗法治疗急性缺血性脑卒中的疗效和安全性。方法应用国际Cochrane协作网的系统评价方法对全世界关于不同药物、剂量、给药途径溶栓疗法治疗急性缺血性脑卒中的随机和半随机对照试验进行了系统评价。结果 共收集到14个已完成的随机对照试验,8个试验(共包括1334例病人)符合纳入标准,其中6个试验比较了不同剂量的t-PA和尿激酶的疗效,3个试验比较了不同药物的疗效。高剂量溶栓治疗组致死性颅内出血事件较低剂量溶栓治疗组显著增加(OR 5.02,95%CI 1.56-16.18),高剂量溶栓治疗组呈现早期死亡或严重出血增加的趋势但未达到统计学意义,远期死亡或颅外出血在高、低剂量组之间无明显差异,不同溶栓药物效果的比较无显著差异。结论 目前尚无足够证据证明是否低剂最溶栓药物治疗急性缺血性脑卒中比高剂量更为安全和有效,亦不能作出一种溶栓药物比另一种更好或哪种给药途径更佳的结论。本系统评价的更新版将于近期在Cochrane图书馆发表。 | 刘鸣 Joanna Wardlaw 张世洪 | 2001 | 中国循证医学2001，1，2： | 2 |
| 12 | Wide Variation in Definition, Detection, and Description of Lacunar Lesions on Imaging显示文摘 | Gillian M. Potter Fergal J. Marlborough Joanna M. Wardlaw | 2011 | Stroke2011，，： | 2 |
| 13 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 14 | Can noninvasive imaging accurately depict intracranial aneurysms? A systematic review显示文摘 | Wardlaw JM Easton V | 2000 | Radiology2000，217，2： | 1 |
| 15 | A ligamentum flarum-preserving approach to the lumbar spinal canal显示文摘 | Askar Z Wardlaw D Choudhary S | 2003 | Spine2003，28，19： | 1 |
| 16 | Can noninvasive imaging accurately depict intracranial aneurysms? A systemic review显示文摘 | White P M Wardlaw J M Easton V | 2000 | Radiology2000，217，9： | 1 |
| 17 | Thrombolysis (different doses,routes of administration and agents) for acute ischaemic stroke显示文摘 | Mielke O Wardlaw J Liu M | 2004 | Cochrane Database Syst Rev2004，，00： | 1 |
| 18 | Systematic review of diffusion and perfusion imaging in acute ischemic stroke显示文摘 | Keir SL Wardlaw JM | 2000 | Stroke2000，31，11： | 1 |
| 19 | Effect of cigarette smoke on CYP1A1,1A2 and CYP2B1/2 of nasal mucosae in F344 rats显示文摘 | WARDLAW SA NIKULA KJ KRACKO DA | 1998 | Carcinogenesis1998，19，4： | 1 |
| 20 | Induced side forces at high angles of attack显示文摘 | WARDLAW A B Jr and MORRISON A M | 1976 | Journal of Spacecraft1976，13，10： | 1 |
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