|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Recent advances in targeting the autotaxin-lysophosphatidate-lipid phosphate phosphatase axis in vivo显示文摘Extracellular lysophosphatidate(LPA) is a potent bioactive lipid that signals through six G-protein-coupled receptors.This signaling is required for embryogenesis,tissue repair and remodeling processes.LPA is produced from circulating lysophosphatidylcholine by autotaxin(ATX),and is degraded outside cells by a family of three enzymes called the lipid phosphate phosphatases(LPPs).In many pathological conditions,particularly in cancers,LPA concentrations are increased due to high ATX expression and low LPP activity.In cancers,LPA signaling drives tumor growth,angiogenesis,metastasis,resistance to chemotherapy and decreased efficacy of radiotherapy.Hence,targeting the ATX-LPA-LPP axis is an attractive strategy for introducing novel adjuvant therapeutic options.In this review,we will summarize current progress in targeting the ATX-LPA-LPP axis with inhibitors of autotaxin activity,LPA receptor antagonists,LPA monoclonal antibodies,and increasing low LPP expression.Some of these agents are already in clinical trials and have applications beyond cancer,including chronic inflammatory diseases. | Matthew G.K. Benesch Xiaoyun Tang Ganesh Venkatraman Raie T. Bekele David N. Brindley | 2016 | The Journal of Biomedical Research2016，30，4： | 9 |
| 2 | 重组日本血吸虫极低密度脂结合蛋白的抗原性及诊断价值的研究显示文摘目的 探讨重组日本血吸虫特异性极低密度脂结合蛋白 (SVLBP)的抗原性及其诊断价值。方法 SVLBP基因亚克隆入pQE - 30表达载体 ,克隆菌在IPTG诱导下表达重组蛋白 ;非变性条件下制备克隆菌裂解液 ,用亲和层析法纯化重组蛋白 ;用Westernblot鉴定其抗原性 ;纯化SVLBP重组蛋白免疫家兔获得抗血清 ;以SVLBP重组蛋白为抗原 ,ELISA法检测血吸虫感染者血清及健康人血清。结果 克隆菌在IPTG诱导下高表达SVLBP重组蛋白 ;该重组蛋白诱导家兔产生单特异抗体 ,抗体滴度为 1∶6 4 0 0 ;SVLBP重组蛋白与血吸虫病人血清有较强的反应 ;以该蛋白为抗原检测 36人份血吸虫感染者血清 ,阳性率为 83.3% ,5 0人份健康人血清 ,假阳性率为 2 % (1/5 0 ) ,10人份肺吸虫病人血清 ,1例阳性 ,交叉反应率为 10 % (1/10 )。结论 SVLBP重组蛋白有较好的抗原性 ,以该重组蛋白为抗原检测日本血吸虫病患者血清中特异性抗体 ,敏感性和特异性均较高 ,具有一定的诊断价值。 | 干小仙 王越 曾肖芃 丁建祖 沈慧英 沈丽英 Paul Brindley 樊晋江 | 2004 | 中国人兽共患病杂志2004，20，8： | 4 |
| 3 | Opisthorchiasis and Opisthorchis -associated cholangiocarcinoma in Thailand and Laos显示文摘 | Banchob Sripa Jeffrey M. Bethony Paiboon Sithithaworn Sasithorn Kaewkes Eimorn Mairiang Alex Loukas Jason Mulvenna Thewarach Laha Peter J. Hotez Paul J. Brindley | 2010 | Acta Tropica2010，，： | 2 |
| 4 | Yohimbine in the treatment of orgasmic dysfunction显示文摘瞄准:与高潮的机能障碍在人的治疗学习育亨宾硷的效果。方法:育亨宾硷的 A 20-mg 剂量首先在诊所与不同原因论的高潮的机能障碍被给 29 个人。病人们然后被允许在更赞成的情形下面在家(滴定) 增加剂量。结果和副作用随后被估计。结果:病人被分类进三组高潮的机能障碍:主要完全(13 ) ,主要不完全(8 ) 并且第二等(8 ) 。梦遗在 75%,40% 是在场的,在上面的 50% 病人组织,分别地(总的来说平均 62%) 。因为富饶问题(52%) ,介绍的人或因为他们想要经历高潮(48%) 的快乐。完成了治疗的 29 个病人, 16 设法到达高潮并且也在手淫或性交期间是有能力的脚趾投掷。进一步,三完成了的 A 达到高潮,但是仅仅与一个震荡器的另外的刺激。前面的梦遗的历史在高潮在被劝诱的 69% 人是在场的但是仅仅 50% 没有通过治疗。病人,二随后生了孩子(双胞胎的一个集合) , 3 个人也是的另外一个治好。副作用不是足够的引起这些人停止治疗。结论:Yohimbineis 在高潮的机能障碍的一种有用治疗选择。 | Ade A. Adeniyi Giles S. Brindley John P. Pryor David J. Ralph | 2007 | Asian Journal of Andrology2007，9，3： | 2 |
| 5 | Drug resistance to schistosomicides and other antelmintics of medical significance显示文摘 | Brindley PJ | 1994 | Acta Trop1994，56，23： | 1 |
| 6 | Ignition properties of thermally thin thermoplastic-the effectiveness of inert additives in reducing flammability显示文摘 | Nelson M I Brindley J McIntosh A C | 1996 | Polym Degrad Stab1996，54，23： | 1 |
| 7 | Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts 显示文摘 | Payne SG Brindley DN Guilbert LJ | 1999 | J Cell Physiol1999，180，2： | 1 |
| 8 | α-enolase autoantibodies cross-reactive to viral proteins in a mouse model of biliary atresia显示文摘 | Lu BR Brindley SM Tucker RM | 2010 | Gastroenterology2010，139，5： | 1 |
| 9 | The tumorigenic liver fluke Opisthorchis viverrini – multiple pathways to cancer显示文摘 | Banchob Sripa Paul J. Brindley Jason Mulvenna Thewarach Laha Michael J. Smout Eimorn Mairiang Jeffrey M. Bethony Alex Loukas | 2012 | Trends in Parasitology2012，，10： | 1 |
| 10 | A numerical study of the vorticity field generated by the baroclinic effect due to the propagation of a planar pressure wave through a cylindrical premixed laminar flame显示文摘 | Batley G A Mcintosh A C Brindley J | 1994 | Journal of Fluid Mechanics1994，279，： | 1 |
| 11 | Proteolytic degradation of host hemoglobin by schistosomes显示文摘 | Brindley PJ Kalinna BH Dalton JP | 1997 | Mol Biochem Parasitol1997，89，： | 1 |
| 12 | Predictors of survival following in- hospital adult cardiopulmonary resuscitation 显示文摘 | Brindley PG Markland DM Maryers I | 2002 | CMAJ2002，167，4： | 1 |
| 13 | A quantitative assessment of inhaled drug particle-pulmonary surfactant interaction by atomic force microscopy显示文摘 | Davies M J Brindley A Chen X Y | 2009 | Colloids and Surfaces B: Biointerfaces2009，73，1： | 1 |
| 14 | Ignition of thermally thin thermoplastics-the effectiveness of inert additives in reducing flammability 显示文摘 | Nelson M I Brindley J Mc Intosh A C | 1996 | Polym Degrad Stab1996，54，： | 1 |
| 15 | Electroejaculation: its technique, neurological implications and uses显示文摘 | | 1981 | J Neurol Neurosurg Psychiatry1981，44，1： | 1 |
| 16 | The sensations produced by electrical stimulation of the visual cortex显示文摘 | Brindley GS Lewin WS | 1968 | J Physiol1968，196，4： | 1 |
| 17 | Dynamic strain ageing in mild steel 显示文摘 | Brindley B J Barely J T | 1966 | Acta Met1966，14，： | 1 |
| 18 | NirJ, a radical SAM family member of the dl heine biogenesis cluster 显示文摘 | Brindley A A Zajicek R Warren M J | 2010 | FEB S Letters2010，584，11： | 1 |
| 19 | Peer assessment in undergraduate programmes显示文摘 | Brindley C Scoffield S | 1998 | Teaching in Higher Education1998，3，1： | 1 |
| 20 | Thermal barrier coating life and isothermal oxidation of low pressure plasma sprayed bond coat alloys显示文摘 | Brindley W J Miller R A | 1991 | Surface and Coating Technology1991，44，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员