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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Helicobacter pylori infection:How does age influence the inflammatory pattern?显示文摘The inflammatory pattern during Helicobacter pylori(H.pylori)infection is changeable and complex.During childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor FOXP3.On the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among H.pylori-positive adults.In the last few years,the participation of the Th17 response in the gastric inflammation against H.pylori infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the infection.Moreover,this cytokine profile might play a pivotal role in the effectiveness of anti-H.pylori vaccines.It is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with H.pylori,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism. | Glauber Rocha Lima Araújo Hanna Santos Marques Maria Luísa Cordeiro Santos Filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa Santos Fabrício Freire de Melo | 2022 | World Journal of Gastroenterology2022，28，4： | 2 |
| 3 | Translation to Portuguese and validation of the Douleur Neuropathique 4 questionnaire显示文摘 | Santos JG Brito JO de Andrade DC | 2010 | Pain2010，11，5： | 1 |
| 4 | Hepatitis D and B virus genotypes in chronically infected patients from the Eastern Amazon Basin显示文摘 | Michele Soares Gomes-Gouvêa Manoel do Carmo Pereira Soares Isabel Maria Vicente Guedes de Carvalho Mello Elisabete Maria Figueiredo Brito Lizomar de Jesus Maués Pereira Moia Gilberta Bensabath Heloisa Marceliano Nunes Flair José Carrilho Jo?o Renato Rebel | 2008 | Acta Tropica2008，，3： | 1 |
| 5 | Selective alveolar corticotomy to intrude overerupted molars显示文摘 | Oliveira DD de Oliveira BF de Araújo Brito HH | | 0，，06： | 1 |
| 6 | Correlating Chlamydia trachomatis infectious load with urogenital ecological success and disease pathogenesis显示文摘 | Jo?o P. Gomes Maria J. Borrego Berna Atik Irene Santo Jacinta Azevedo Armando Brito de Sá Paulo Nogueira Deborah Dean | 2005 | Microbes and Infection2005，，1： | 1 |
| 7 | Gastrointestinal Symptoms and Nutritional Status in Women and Men on Maintenance Hemodialysis显示文摘 | Luciana Ferreira Silva Gildete Barreto Lopes Cácia Mendes Matos Katherine Quadros Brito Maurício Kauark Amoedo Matheus Freitas Azevedo Meiry Jane Sá Araújo Márcia Silva Martins Antonio Alberto Lopes | 2012 | Journal of Renal Nutrition2012，，3： | 1 |
| 8 | Selective alveolar corticotomy to intrude overerupted molars显示文摘 | Oliveira DD de Oliveira BF de Araújo Brito HH | 2008 | Am J Orthod Dentofacial Orthop2008，133，6： | 1 |
| 9 | Azilsartan increases levels of IL-10,down-regulates MMP-2,MMP-9,RANKL/RANK,Cathepsin K and up-regulates OPG in an experimental periodontitis model显示文摘 | de Araújo A A Varela H de Castro Brito G A | 2014 | PLo S One2014，9，96： | 1 |
| 10 | Anal canal gastrointestinal stromal tumors:Case report and literature review显示文摘Gastrointestinal stromal tumors(GIST)are an uncommon group of tumors of mesenchymal origin.GIST of the anal canal is extremely rare.At present,only 10cases of c-kit positive anal GIST have been reported in the literature.There is no widely accepted treatment approach for this neoplasia.Literature is sparse on imaging evaluation of anal canal GIST,usually described as a lesion in the intersphincteric space.We describe the case of a 73-year-old man with a mass in the anal canal,and no other symptoms.Endoanal ultrasound and magnetic resonance imaging showed a well circumscribed solid nodule in the intersphincteric space.The patient was treated by local excision.Gross pathological examination showed a 7 cm×3.5 cm×3cm mass,and histological examination showed a proliferation of spindle cells,with prominent nuclear palisading.The mitotic count was of 12 mitoses/50 HPF.The tumor was positive for KIT protein,CD34 and vimentin in the majority of cells,and negative for desmin and S100.A diagnosis of GIST,with high risk aggressive behavior was made.An abdomino-perineal resection was discussed,but refused.The follow-up included clinical evaluation and anal ultrasound.After 5 years the patient is well,with maintained continence and no evidence of local recurrence. | Nuno Carvalho Diogo Albergaria Rui Lebre Joo Giria Vitor Fernandes Helena Vidal Maria José Brito | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 11 | Current trending and beyond for solar-driven water splitting reaction on WO_(3)photoanodes显示文摘This review shows the importance of WO_(3)photoanode as a potentially low-cost,efficient,stable,and photoactive material for light-driven water splitting.For such,this manuscript aims to review the most recent publications regarding the strategies to improve the phoelectroactivity of WO_(3)films for water oxidation.In addition,this review aims to graphically highlight and discuss the general trendings of the photocurrent density response and stability test of the recent outstanding studies in the literature for photoelectrochemical water splitting application.The strategies covered in this review will not only concern the WO_(3)morphology and crystal plane growth,but also the many arrangements possibilities to improve the WO_(3)efficiency for water photoelectrooxidation,such as defect engineering based on oxygen vacancies,doping,decorations,and homo and heterojunctions.All these strategies are compared by the photocurrent density results and by the stability of these photocatalysts.The best results in this sense were observed in cases where the use of heterojunction was applied together with a desired morphology and crystal plane of the WO_(3)photoanode.However,the modifications that caused a decrease in the photocurrent density reaching values that are even lower than the pure WO_(3)were also discussed.In this way,this review intends to improve the knowledge about the synthesis and design of WO_(3)photoanodes to further obtain an efficient photocatalyst to minimize the recombination losses or losses across the interfaces and improve the photoelectroactivity for water splitting in the large-scale application. | Magno B.Costa Moisés A.de Araújo Marcos V.de Lima Tinoco Juliana F.de Brito Lucia H.Mascaro | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 12 | Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil显示文摘Qualitative antibody tests are an easy,point-of-care diagnostic method that is useful in diagnosing coronavirus disease 2019,especially in situations where reverse transcription-polymerase chain reaction is negative.However,some factors are able to affect its sensitivity and accuracy,which may contribute to these tests not being used as a first-line diagnostic tool. | Fabrício Freire de Melo Lilian Martins Oliveira Diniz JoséNélio Januário João Fernando Gonçalves Ferreira Rafael Santos Dantas Miranda Dórea Breno Bittencourt de Brito Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Dulciene Maria de Magalhães Queiroz | 2022 | World Journal of Experimental Medicine2022，12，5： | 0 |
| 13 | Enterobacteria and Vibrio from Macrobrachium amazonicum prawn farming in Fortaleza,Ceará,Brazil显示文摘Objective:To investigate the isolation of enterobacteria associated with Macrobrachium amazonicum(M.amazonicum) farming and evaluate the in vitro antimicrobial susceptibility of Vibrio strains.Methods:Strains were isolated from female M.amazonicum prawns and environmental and hatchery water.Biochemical assays were used to identify bacterial genera and those belonging to the genus Vibrio were submitted to further analyses for species identification,through Vitek 2 automated system and scrotyping.Susceptibility test was performed according to Clinical Laboratory Standards Institute.Results:The following genera of enlerobacteria were recovered:Enterobacter(n=11),Citrobacter(n=10),Proteus(n=2),Serratia(n=2),Kluyvera(n=2),Providencia(n=2),Cedecea(n=1),Escherichia(n=1).Edwardsiella(n=1) and BulliauxeUa(n=1).As for Vibrio,three species were identified:Vibrio cholerae non-O1/non-O139(n=4).Vibrio vulnificus(V.vulnificus)(n=1) and Vibrio mimicus(n=1).Vibrio spp.showed minimum inhibitory concentrations values within the susceptibility range established by Clinical Laboratory Standards Institute for almost all antibiotics,except for V.vulnificus,which presented intermediate profile to ampicillin.Conclusions:Enterobacteria do not seem to be the most important pathogens associated with M.amazonicum farming,whereas the recovery of Vibrio spp.from larviculture,with emphasis on Vibrio cholerae and V.vulnificus,deserves special attention due to their role as potentially zoonotic aquaculture-associated pathogens.Furthermore,the intermediate susceptibility of V.vulnificus to ampicillin reflects the importance of monitoring drug use in prawn farming. | Débora de Souza Collares Maia Castelo-Branco Jamille Alencar Sales Raimunda Samia Nogueira Brilhante Glaucia Morgana de Melo Guedes Yago Brito de Ponte Celia Maria de Souza Sampaio Tereza de Jesus Pinheiro Gomes Bandeira José Luciano Bezerra Moreira Lucas Pereira de Alencar Manoel de Araújo Neto Paiva Rossana de Aguiar Cordeiro André Jalles Monteiro Waldemiro de Aquino Pereira-Neto José Júlio Costa Sidrim Marcos Fábio Gadelha Rocha | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，1： | 0 |
| 14 | Tertiary peritonitis: A disease that should not be ignored显示文摘Intra-abdominal infections can be classified into uncomplicated or complicated(peritonitis). Peritonitis is divided into primary, secondary, and tertiary. Tertiaryperitonitis is the less common but the most severe among peritonitisstratifications, being defined as a recurrent intra-abdominal infection that occurs48 h after a well-succeeded control of a secondary peritonitis. This disease has acomplex pathogenesis that is closely related to the capacity of the peritonealcavity to activate immunological processes. Patients who progress to persistentperitonitis are at an increased risk of developing several infectious complicationssuch as sepsis and multiple organ failure syndrome. Moreover, tertiary peritonitisremains an important cause of hospital death mainly among patients withassociated risk factors. The microbiological profile of organisms causing tertiaryperitonitis is often different from that observed in other types of peritonitis. Inaddition, there is a high prevalence of multidrug-resistant pathogens causing thiscondition, and an appropriate and successful clinical management depends on anearly diagnosis, which can be made easier with the use of clinical scorespresenting a good prediction value during the intensive care unit admission.Complementarily, immediate therapy should be performed to control theinfectious focus and to prevent new recurrences. In this sense, the treatment isbased on initial antimicrobial therapy and well-performed peritoneal drainage. | Hanna Santos Marques Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito Paulo Victor Dias Versiani Jaqueline Silva Caires Thiago de Carvalho Milet Fabrício Freire de Melo | 2021 | World Journal of Clinical Cases2021，9，10： | 0 |
| 15 | A soil quality index for subtropical sandy soils under different Eucalyptus harvest residue managements显示文摘Eucalyptus harvest residues are attractive energy production resources for the forestry industry.However,their removal can have adverse impacts on soil quality and forest productivity,especially in sandy soils.In this study,we assessed the effects of Eucalyptus harvest residue managements with variable intensity on forest productivity and on physical,chemical,and biological indicators of the soil quality.The experiment was conducted in a Quartzipsamment(33 g kg-1clay)planted with Eucalyptus saligna in Barra do Ribeiro in southern Brazil.Before the Eucalyptus was planted,residues from the previous rotation were subjected to five different management treatments:(1)FRM,in which all forest residues(bark,branches,leaves,and litter)were allowed to remain on the soil and only trunk wood was removed;(2)FRMB,in which was identical to FRM except that bark was also removed;(3)FRMBr,in which only trunk wood and branches were removed;(4)FRR,which involved removing all types of residues(bark,branches,leaves,and litter);and,(5)FRRs,in which all forest residues from the previous rotation were removed,and leaves and branches from the new plantation were prevented from falling onto the soil surface using a shade net.Six years after planting,soil samples were collected at four different depths(0-2.5,2.5-5,5-10,and 10-20 cm)to determine 17 soil chemical,physical,and biological indicators.The results were combined into a soil quality index(SQI)using the principal component analysis approach.The SQI reduced by 30%,in the 0-20 cm layer,due to removal of harvest residues from the previous rotation,and collection of litter before it falls on the ground.The main drivers of SQI reduction were the principal components associated with soil organic matter and biological activity.Furthermore,the SQI was positively linearly related to tree height at P<0.01 and to tree diameter at breast height at P=0.07.The adverse impact on soil quality and forest productivity in our study indicates that removal of Eucalyptus harvest residues from sandy soils should be avoided. | Jackson Freitas Brilhante de Sao José Maurício Roberto Cherubin Luciano Kayser Vargas Bruno Brito Lisboa Josiléia Acordi Zanatta Elias Frank Araújo Cimélio Bayer | 2023 | Journal of Forestry Research2023，34，1： | 0 |
| 16 | Influence of the COVID-19 pandemic in the gastrointestinal oncology setting:An overview显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been impacting healthcare in various ways worldwide and cancer patients are greatly affected by the coronavirus disease 2019(COVID-19)pandemic.The reorganization of the health facilities in order to supply the high demand resulting from the aforementioned infection as well as the social isolation measures led to impairments for the diagnosis and follow-up of patients with gastrointestinal cancers,which has had an impact on the prognosis of the oncologic patients.In that context,health authorities and organizations have elaborated new guidelines with specific recommendations for the management of individuals with gastrointestinal neoplasms during the pandemic.Of note,oncologic populations seem to be more susceptible to unfavorable outcomes when exposed to SARS-CoV-2 infection and some interactions involving virus,tumor,host immune system and anticancer therapies are probably related to the poorer prognosis observed in those COVID-19 patients.Moreover,vaccination stands out as the main prevention method against severe SARS-CoV-2 infection and some particularities have been observed regarding the seroconversion of vaccinated oncologic patients including those with gastrointestinal malignancies.In this minireview,we gather updated information regarding the influence of the pandemic in the diagnosis of gastrointestinal neoplasms,new recommendations for the management of gastrointestinal cancer patients,the occurrence of SARSCoV-2 infection in those individuals and the scenario of the vaccination against the virus in that population. | Breno Bittencourt de Brito Hanna Santos Marques Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Glauber Rocha Lima Araújo Lara de Araujo Valente Fabrício Freire de Melo | 2022 | World Journal of Gastrointestinal Pathophysiology2022，13，5： | 0 |
| 17 | Maternal low protein diet induces persistent expression changes in metabolic genes in male rats显示文摘BACKGROUND Perinatal exposure to a poor nutritional environment predisposes the progeny to the development of metabolic disease at the adult age,both in experimental models and humans.Numerous adaptive responses to maternal protein restriction have been reported in metabolic tissues.However,the expression of glucose/fatty acid metabolism-related genes in adipose tissue and liver needs to be described.AIM To evaluate the metabolic impact of perinatal malnutrition,we determined malnutrition-associated gene expression alterations in liver and adipose tissue.METHODS In the present study,we evaluated the alterations in gene expression of glycolytic/Krebs cycle genes(Pyruvate dehydrogenase kinase 4 and citrate synthase),adipogenic and lipolytic genes and leptin in the adipose tissue of offspring rats at 30 d and 90 d of age exposed to maternal isocaloric low protein(LP)diet throughout gestation and lactation.We also evaluated,in the livers of the same animals,the same set of genes as well as the gene expression of the transcription factors peroxisome proliferator-activated receptor gamma coactivator 1,forkhead box protein O1 and hepatocyte nuclear factor 4 and of gluconeogenic genes.RESULTS In the adipose tissue,we observed a transitory(i.e.,at 30 d)downregulation of pyruvate dehydrogenase kinase 4,citrate synthase and carnitine palmitoyl transferase 1b gene expression.Such transcriptional changes did not persist in adult LP rats(90 d),but we observed a tendency towards a decreased gene expression of leptin(P=0.052).The liver featured some gene expression alterations comparable to the adipose tissue,such as pyruvate dehydrogenase kinase 4 downregulation at 30 d and displayed other tissue-specific changes,including citrate synthase and fatty acid synthase upregulation,but pyruvate kinase downregulation at 30 d in the LP group and carnitine palmitoyl transferase 1b downregulation at 90 d.These gene alterations,together with previously described changes in gene expression in skeletal muscle,may account for the metabolic adaptations in response to maternal LP diet and highlight the occurrence of persistent transcriptional defects in key metabolic genes that may contribute to the development of metabolic alterations during the adult life as a consequence of perinatal malnutrition.CONCLUSION We conclude that perinatal malnutrition relays long-lasting transcriptional alterations in metabolically active organs,i.e.,liver and adipose tissue. | Allan de Oliveira Lira JoséLuiz de Brito Alves Mariana Pinheiro Fernandes Diogo Vasconcelos David Filipe Santana João Henrique da Costa-Silva Béatrice Morio Carol Góis Leandro Luciano Pirola | 2020 | World Journal of Diabetes2020，11，5： | 0 |
| 18 | Disordered eating behaviour and eating disorder among adolescents with type 1 diabetes:An integrative review显示文摘BACKGROUND Type 1 diabetes(DT1)in adolescents brings behavioural changes,altered nutritional habits,and eating disorders.AIM To identify and analyze the validated instruments that examine the disordered eating behaviour and eating disorders among adolescents with DT1.METHODS An integrative review was accomplished based on the following databases:PubMed,LILACS,CINAHL,Scopus,Web of Science,and Reference Citation Analysis(RCA),including publications in Portuguese,English,or Spanish,without time limit and time published.RESULTS The main instruments to evaluate disordered eating behaviour were The Diabetes Eating Problem Survey-Revised,The Diabetes Eating Problem Survey,and the eating attitudes test-26,and for eating disorders the main instruments used were The Bulimic Investigation Test of Edinburgh,The Binge Eating Scale,The Child Eating Disorder Examination,The five questions of the(Sick,Control,One,Fat and Food),and The Mind Youth Questionnaire.These instruments showed an effect in evaluating risks regarding nutritional habits or feeding grievances,with outcomes related to weight control,inadequate use of insulin,and glycaemia unmanageability.We did not identify publication bias.CONCLUSION Around the world,the most used scale to study the risk of disordered eating behaviour or eating disorder is The Diabetes Eating Problem Survey-Revised.International researchers use this scale to identify high scores in adolescents with DT1 and a relationship with poorer glycemic control and psychological problems related to body image. | Maria Conceição Santos Oliveira Cunha Francisco Clécio Silva Dutra Laura Martins Mendes Cavaleiro Brito Rejane Ferreira Costa Maria Wendiane Gueiros Gaspar Danilo Ferreira Sousa Márcio Flávio Moura deAraújo Maria Veraci Oliveira Queiroz | 2022 | World Journal of Meta-Analysis2022，10，5： | 0 |
| 19 | Correction to“Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil”显示文摘Correction to“Freire de Melo F,Martins Oliveira Diniz L,Nélio Januário J,Fernando Gonçalves Ferreira J,Dórea RSDM,de Brito BB,Marques HS,Lemos FFB,Silva Luz M,Rocha Pinheiro SL,de Magalhães Queiroz DM.Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil.World J Exp Med 2022;12(5):100-103[PMID:36196438 DOI:10.5493/wjem.v12.i5.100]”.In this article,we identified an issue with the“Acknowledgments”section.Here,we then provide a recognition section for our supporting institutions. | Fabrício Freire de Melo Lilian Martins Oliveira Diniz JoséNélio Januário João Fernando Gonçalves Ferreira Rafael Santos Dantas Miranda Dórea Breno Bittencourt de Brito Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Gifone Aguiar Rocha Dulciene Maria de Magalhães Queiroz | 2023 | World Journal of Experimental Medicine2023，13，3： | 0 |
| 20 | Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern worldwide.In that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and remedy.AIM To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease outcomes.METHODS This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian hospital.RESULTS The patients had a median age of 65.60±15.78 years.Dyspnea was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the patients.At least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with death.Nausea and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective factor.CONCLUSION This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected individuals.The associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features. | Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior Maria Teresa Araújo de Lorenzo Barcia Renata de Amorim Marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda Marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo | 2023 | World Journal of Clinical Cases2023，11，8： | 0 |
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