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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Streptococcus agalactiae:Identification methods,antimicrobial susceptibility, and resistance genes in pregnant women显示文摘BACKGROUND Group B Streptococcus(GBS)is a normal component of the gastrointestinal and genital microbiota in humans and can lead to important infections in newborns.AIM To compare GBS isolation and identification methods as well as to assess the antibiotic susceptibility and to identify resistance genes in GBS strains from pregnant women attended in healthcare services from the city of Vitória da Conquista,in Bahia State,Brazil.METHODS From January 2017 to February 2018,vaginorectal swabs were obtained from 186 participants and the samples were seeded onto chromogenic agar for GBS before and after inoculation in selective broth.Confirmatory identification using 3 CAMP and latex tests was performed in samples with GBS-suggestive colonies.Then,disk diffusion antibiograms were performed in GBS-positive samples,and the detection of the resistance genes ermB,ermTR,mefA,and linB in the clindamycin and/or erythromycin-resistant samples was carried out.RESULTS Thirty-two samples(17.2%)were GBS-positive.The culture in chromogenic agar after sample incubation in selective broth was the most sensitive method(96.9%)for GBS detection.All isolates were susceptible to penicillin,ampicillin,cefotaxime,and vancomycin.Clindamycin resistance was observed in 6 samples(18.8%),while 8 samples(25%)were erythromycin-resistant.All erythromycin and/or clindamycin-resistant GBS strains had negative D-tests.Two strains(25%)presented an M phenotype and 6 isolates(75%)presented a cMLSB phenotype.The ermB gene was identified in 4 samples(44.4%),the mefA gene was also found in 4 samples(44.4%),the ermTR gene was identified in 1 isolate(11.1%),and the linB gene was not found in any isolate.CONCLUSION This study evidenced that the screening for SGB can be performed by means of various methods,including chromogenic media,and that the chemoprophylaxis for pregnant women who cannot use penicillin must be susceptibility-guided. | Fabrícia Almeida Fernandes Santana Tais Viana Ledo de Oliveira Marcelo Barreto de Souza Filho Lucas Santana Coelho da Silva Breno Bittencourt de Brito Fabrício Freire de Melo Cláudio Lima Souza Lucas Miranda Marques Márcio Vasconcelos Oliveira | 2020 | World Journal of Clinical Cases2020，8，18： | 2 |
| 3 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 4 | The overlap of Sjsgren' s syndrome with other systemic autoimmune diseases 显示文摘 | Ramos-Casals M Brito - Zeron P Font J | 2007 | Semin Arthritis Rheum2007，36，4： | 1 |
| 5 | The accuracy of thyroid nodule ultrasound to predict thyroid cancer: systematic review and meta-analysis 显示文摘 | BRITO J P GIONFRIDDO M R A L NOFAL A | 2014 | J Clin Endocrinol Metab2014，99，4： | 1 |
| 6 | Processing strategy for producing highly anisotropic silicon nitride 显示文摘 | Hirao K Ohashi M Brito M E | 1995 | Journal of the American Ceramic Society1995，78，6： | 1 |
| 7 | Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis显示文摘 | Moura LM Faria S Brito M | 2012 | Am J Cardiovasc Dis2012，2，： | 1 |
| 8 | Evaluation of the main MPPT techniques for photovoltaic applications显示文摘 | De Brito M A G Galotto L Sampaio L P | 2013 | IEEE Transactionson Industrial Electronics2013，60，3： | 1 |
| 9 | Concrete made with used tyre aggre-gate :durability -related performance 显示文摘 | Bravo M De Brito J | 2012 | Journal of Cleaner Pro-duction2012，，25： | 1 |
| 10 | Cytokine levels ( IL - 6 and IFN - γ) acute phase response and nu- tritional status as prognostic actors in lung cancer 显示文摘 | Antonio M ilena Em ilio Gonzlez -Reimers M aria J Brito | 1999 | Cytokine1999，11，1： | 1 |
| 11 | Zero-dimensional model for preliminary design of ablative pulsed plasma Teflon thrusters 显示文摘 | Brito C M Elaskar S A Brito H H | 2004 | Journal of Propulsion and Power2004，20，6： | 1 |
| 12 | The accuracy of thyroid nodule ultrasound to predict thyroid cancer:systematic review and meta-analysis显示文摘 | Brito J P Gionfriddo M R Al Nofal A | 2013 | The Journal of Clinical Endocrinology&Metabolism2013，99，4： | 1 |
| 13 | Optimisation and validation of a quantitative and confirmatory LC-MS method for multi-residue analyses ofβ-lactam and tetracycline antibiotics in bovine muscle显示文摘 | REZENDE C P ALMEIDA M P BRITO R B | 2012 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess2012，29，4： | 1 |
| 14 | Effect of the gamma radiation dose rate on psychrotrophic bacteria, thiobarbituric acid reactive substances, and sensory characteristics of mechanically deboned chicken meat 显示文摘 | Brito P P Azevedo H Cipolli K M Fukuma H T Moutao G B Roque C V Miya N T Pereira J L | 2011 | Journal of Food Science2011，76，2： | 1 |
| 15 | Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death显示文摘 | Brito C Naviliat M Tiscornia AC | 1999 | J Immunol1999，162，6： | 1 |
| 16 | Specification of exception flow in software architecture显示文摘 | Castor F F Brito P H Rubira C M | 2006 | The Journal of System & Software2006，79，10： | 1 |
| 17 | Bacterial biodiversity from anthropogenic extreme environments: a hyper-alkaline and hyper- saline industrial residue contaminated by chromium and iron显示文摘 | Brito E M Pion-Castillo H A Guyoneaud R | 2013 | Applied microbiology and biotechnology2013，97，1： | 1 |
| 18 | Community genomics among stratified microbial assemblages in the ocean's interior显示文摘 | DeLong E F Preston C M Mincer T Rich V Hallam S J Frigaard N U Martinez A Sullivan M B Edwards R Brito B R Chisholm S W Karl D M | | 0，，5760： | 1 |
| 19 | Photovoltaic potential in a Lisbon suburb using LiDAR data显示文摘 | Brito M C Gomes N Santos T | 2012 | Solar Energy2012，86，1： | 1 |
| 20 | Theaccuracy of thyroid nodule ultrasound to predict thyroidcancer: systematic review and meta-analysis 显示文摘 | BRITO J P GIONFRIDDO M R AL NOFAL A | 2014 | J ClinEndocrinol Metab2014，99，4： | 1 |
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