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| 1 | Nogo domains and a Nogo receptor: implications for axon regeneration显示文摘 | Brittis P A Flanagan J G | 2001 | Neuron2001，30，1： | 1 |
| 2 | Nogo Domains and a Nogo Receptor:Implications for Axon Regeneration显示文摘 | Perry A Brittis John G Flanagan | 2001 | Neuron2001，，1： | 1 |
| 3 | Nogo domains and a Nogo receptor:implications for axon regeneration显示文摘 | Brittis PA Flanagan JG | 2001 | Neuron2001，30，1： | 1 |
| 4 | Chondroitin sulfate as a regulator of neuronal patterning in the retina显示文摘 | Brittis PA Canning DR Silver J | 1992 | Science1992，255，5045： | 1 |
| 5 | Probiotic bacteria Bifidobacterium animalis MB5 and Lactobacillus rhamnosus GG protect intestinal Caco-2 cells from the inflammation-associated response induced by enterotoxigenic Escherichia coli K88显示文摘 | ROSELLI M FINAMORE A BRITTI M S | | 0，，06： | 1 |
| 6 | Expression of matrix metalloproteinase-11 is increased under conditions of insulin resistance显示文摘AIM To investigate matrix metalloproteinase-11(MMP-11) expression in adipose tissue dysfunction, using in vitro and in vivo models of insulin resistance.METHODS Culture of mouse 3T3-L1 preadipocytes were induced to differentiation into mature 3T3-L1 adipocytes. Cellular insulin resistance was induced by treating differentiated cultured adipocytes with hypoxia and/or tumor necrosis factor(TNF)-α, and transcriptional changes were analyzed in each condition thereafter. For the in vivo studies, MMP-11 expression levels were measured in white adipose tissue(WAT) from C57BL/6J mice that underwent low fat diet or high-fat feeding in order to induce obesity and obesity-related insulin resistance. Statistical analysis was carried out with GraphP ad Prism Software.RESULTS MMP-11 m RNA expression levels were significantly higher in insulin resistant 3T3-L1 adipocytes compared to control cells(1.46±0.49vs0.83±0.21, respectively;P<0.00036). The increase in MMP-11 expression was observed even in the presence of TNF-α alone(3.79±1.11vs1±0.17, P<0.01) or hypoxia alone(1.79±0.7vs0.88±0.1, P<0.00023). The results obtained in in vitro experiments were confirmed in the in vivo model of insulin resistance. In particular, MMP-11 m RNA was upregulated in WAT from obese mice compared to lean mice(5.5±2.8vs1.1±0.7, respectively; P<3.72E-08). The increase in MMP-11 levels in obese mice was accompanied by the increase in typical markers of fibrosis, such as collagen type Ⅵ alpha 3(Col6_α3), and fibroblast-specific protein 1.CONCLUSION Our results indicate that dysregulation of MMP-11 expression is an early process in the adipose tissue dysfunction, which leads to obesity and obesity-related insulin resistance. | Biagio Arcidiacono Eusebio Chiefari Anna Elisa Laria Sebastiano Messineo Francesco Luciano Bilotta Domenico Britti Daniela Patrizia Foti Anna Foryst-Ludwig Ulrich Kintscher Antonio Brunetti | 2017 | World Journal of Diabetes2017，8，9： | 1 |
| 7 | Gemcitabine-loaded liposomes : rationale,potentialities and futureperspectives 显示文摘 | Federico C Morittu V M Britti D | 2012 | Int J Nanomedicine2012，7，1： | 1 |
| 8 | The earliest patterns of neuronal differentiation and migration in the mammalian central nervous system显示文摘 | BRITTIS P A MEIRI K DENT E | 1995 | Exp Neurol1995，134，1： | 1 |
| 9 | Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target显示文摘 | LU Q FLANAGAN J G | 2002 | Cell2002，110，： | 1 |
| 10 | The novel porcine Lactobacillus sobrius strain protects in- testinal cells from enterotoxigenic Escherichia coli K88 infection and prevents membrane barrier damage 显示文摘 | ROSELLI M FINAMORE A BRITTI M S | 2007 | The Journal of Nutrition2007，137，12： | 1 |
| 11 | Alternatives to infeed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa显示文摘 | Roselli M Finamore A Britti M S | 2005 | Anita Res2005，54，： | 1 |
| 12 | Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo显示文摘 | Patel N S Sharples E J Cuzzocrea S Chatterjee P K Britti D Yaqoob M M | 2004 | Kidney Int2004，66，： | 1 |
| 13 | Nogo domains and a Nogo receptor: implications for axon regeneration显示文摘 | Brittis PA Flanagan JG | 2001 | Neuron2001，30，1： | 1 |
| 14 | Intestinal and peripheral immune response to MONSIO maize ingestion in weaning and old mice显示文摘 | Finamore A Roselli M Britti S | 2008 | J Agric Food Chem2008，56，11： | 1 |
| 15 | Unique changes of ganglion cell growth cone behavior following cell adhesion molecule perturbations: a time-lapse study of the living retina显示文摘 | Brittis PA Lemmon V Rutishauser U Silver J | 1995 | Mol Cell Neurosci1995，6，5： | 1 |
| 16 | Nogo domains and a Nogo receptor:implications for axon regeneration显示文摘 | Brittis PA Flanagan JG | 2001 | Neuron2001，30，： | 1 |
| 17 | Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat显示文摘 | CUZZOCREA S MCDONALD M C MAZZON E MOTA-FILIPE H CENTORRINO T TERRANOVA M L CICCOLO A BRITTI D CAPUTI A P THIEMERMANN C | 2001 | Gut2001，48，4： | 1 |
| 18 | Intestinal and peripheral immune response to MON810 maize ingestion in weaning and old mice显示文摘 | Finamore A Roselli M Britti S | | 0，，23： | 1 |
| 19 | Effect of different plant extracts and natural substances (PENS) against membrane damage induced by enterotoxigenic escherichia coli K88 in pig intestinal cells 显示文摘 | Roselli M Britti MS Le Huerou-Luron I | 2007 | Toxicol In Vitro2007，21，2： | 1 |
| 20 | Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammnation显示文摘 | Cuzzocre S Chattetjee PK Mazzon E Dugo L Serraino I Britti D | 2002 | Br J Pharmaeol2002，135，2： | 1 |
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