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| 1 | Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes显示文摘The global prevalence of diabetes mellitus is increasing; arguably as a consequence of changes in diet, lifestyle and the trend towards urbanization. Unsurprisingly, the incidence of both micro and macrovascular complications of diabetes mirrors this increasing prevalence. Amongst the complications with the highest symptom burden, yet frequently under-diagnosed and sub-optimally treated, is diabetic autonomic neuropathy, itself potentially resulting in cardiovascular autonomic neuropathy and gastrointestinal(GI) tract dysmotility. The aims of this review are fourfold. Firstly to provide an overview of the pathophysiological processes that cause diabetic autonomic neuropathy. Secondly, to discuss both the established and emerging cardiometric methods for evaluating autonomic nervous system function in vivo. Thirdly, to examine the tools for assessing pan-GI and segmental motility and finally, we will provide the reader with a summary of putative non-invasive biomarkers that provide a pathophysiological link between lowgrade neuro inflammation and diabetes, which may allow earlier diagnosis and intervention, which in future may improve patient outcomes. | Christina Brock Birgitte Brock Anne Grave Pedersen Asbjorn Mohr Drewes Niels Jessen Adam D Farmer | 2016 | World Journal of Diabetes2016，7，16： | 5 |
| 2 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 3 | 骨巨细胞瘤治疗新突破——狄诺塞麦显示文摘骨巨细胞瘤(GCTB)是一种富含巨细胞的侵袭性、溶骨性病变,特征为大量多核破骨细胞样巨细胞聚集、表达细胞核因子κB受体活化因子配体(RANKL),目前还没有一种方法可彻底有效治愈,尤其是对无法手术的GCTB。近年文献报道在进行性或无法手术的GCTB患者中使用狄诺塞麦(denosumab),可观察到肿瘤成分明显改变、骨破坏减少及临床有效性。狄诺塞麦是一种人RANKL单克隆抗体,与核因子κB受体活化因子(RANK)结合具有很高的亲和性和特异性。以往很多大规模Ⅲ期试验研究已表明,狄诺塞麦在降低各种肿瘤引起的骨破坏方面明显优于二磷酸盐,还可延缓骨转移出现。该文对相关文献进行回顾,并就狄诺塞麦在GCTB治疗中存在的问题进行探讨。 | 许宋锋 Brock Adams 于秀淳 徐明 | 2013 | 国际骨科学杂志2013，34，6： | 2 |
| 4 | Almost alternating links显示文摘 | ADAMS C C BROCK J F BUGBEE J | 1992 | Topology and its applications1992，46，： | 1 |
| 5 | Long-Term Urological Impact of Fetal Myelomeningocele Closure显示文摘 | Douglass B. Clayton Stacy T. Tanaka Lisa Trusler John C. Thomas John C. Pope Mark C. Adams John W. Brock | 2011 | The Journal of Urology2011，，4： | 1 |
| 6 | Efficacy and complications of covered Wallstents in malignant distal biliary obstruction <ce:link locator='fx1'/>显示文摘 | Michel Kahaleh Jeffrey Tokar Mark R. Conaway Andrew Brock Tri Le Reid B. Adams Paul Yeaton | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 7 | Almost alternting links显示文摘 | ADAMS C C BROCK J F COMAR T D FAIGIN K A HUSTON A M JOSEPAND A M PESIKOFF D | 1992 | Topology and Its Applications1992，46，： | 1 |
| 8 | Potential risk factors associated with progressive renal damage in childhood urological diseases:the role of angiotensin-converting enzyme gene polymorphism显示文摘 | Brock JW Adams M Hunley T | 1997 | J Urol1997，158，32： | 1 |
| 9 | How they begin and how they end:classic and new theories for the development and deterioration of congenital anomalies of the kidney and urinary tract, CAKU显示文摘 | Pope JC Brock JW Adams MC | 1999 | J AM Soc Nephrol1999，10，： | 1 |
| 10 | Efficacy and complications of covered Wallstents in malignant distal biliary obstruction显示文摘 | Kahaleh M Tokar J Conaway M R Brock A Le T Adams R B | 2005 | Gastrointest Endosc2005，61，： | 1 |
| 11 | How they begin and how they end:classic and new theories for the development and deterioration of congenital anomalies of the kidney and urinarg tract显示文摘 | Pope JC Brock JW Adams MC | 1999 | J Am Soc Nephrol1999，10，10： | 1 |
| 12 | Almost Alternating Links显示文摘 | ADAMS C BROCK J BUGBEE J | 1992 | Topology and Its Applications1992，46，： | 1 |
| 13 | How they begin and how they end:classic and new theories for the development and deterioration of congenital anomalies of the kidney and urinary tract (CAKUT) 显示文摘 | Pope JC 4th Brock JW 3rd Adams MC | 1999 | J Am Soc Nephrol1999，10，9： | 1 |
| 14 | Almost Altemating Links 显示文摘 | Brock J F Bugbee J | 1992 | Topology and Its Applications1992，46，： | 1 |
| 15 | Mesenchymal Stem Cell Recruitment and Improved Bladder Function After Bladder Outlet Obstruction: Preliminary Data显示文摘 | Lynn L. Woo Stacy T. Tanaka Govindaraj Anumanthan John C. Pope John C. Thomas Mark C. Adams John W. Brock Neil A. Bhowmick | 2011 | The Journal of Urology2011，，3： | 1 |
| 16 | The bigness Mystique and the merger policy debate: and international perspective 显示文摘 | ADAMS W J W BROCK | 1988 | Northwestern Journal of International Law and Business1988，9，： | 1 |
| 17 | Efficacy and complications of covered Wallstents in malignant distal biliary obstruction 显示文摘 | Michel Kahaleh Jeffrey Tokar Mark R. Conaway Andrew Brock Tri Le Reid B. Adams Paul Yeaton | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 18 | Directed Differentiation of Bone Marrow Derived Mesenchymal Stem Cells Into Bladder Urothelium显示文摘 | Govindaraj Anumanthan John H. Makari Lindsey Honea John C. Thomas Marcia L. Wills Neil A. Bhowmick Mark C. Adams Simon W. Hayward Robert J. Matusik John W. Brock John C. Pope | 2008 | The Journal of Urology2008，，4： | 1 |
| 19 | How they begin and how they end: classic and new theories for the development and deterioration of cor~genital anomalies ot the kidney and urinary tract, CAKUT显示文摘 | Pope JC Brock JW Adams MC | 1999 | J Am Soc Nephrol1999，10，： | 1 |
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