|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Network applications of Bloom Filters : asurvey显示文摘 | Broder A Mitzenmacher M | 2004 | Internet Mathematics2004，1，4： | 1 |
| 3 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 4 | Min-wise independent permutations 显示文摘 | Broder A Z Charikar M Frieze A M | 2000 | Journal of Computer and System Sciences2000，60，3： | 1 |
| 5 | Reliability and convergent and discriminant validity of the Child Oral Health Impact Profile (COHIP Child's version) 显示文摘 | Broder HL Wilson-Genderson M | 2007 | Community Dent Oral Epidemiol2007，35，1： | 1 |
| 6 | Impaired synthesis of polyclonal (non-paraprotein) immtmoglobulins by circulating lymphocytes from patients with multiple myeloma: role of suppressor ceils 显示文摘 | Broder S Humphrey R Durm M | 1975 | New Engl J Med1975，293，18： | 1 |
| 7 | The FIGO recommendations on terminologies and definitions for normal and abnormal uterine bleeding显示文摘 | Fraser IS Critchley HO Broder M | 2011 | Semin Reprod Med2011，29，： | 1 |
| 8 | Syntactic clustering of the web 显示文摘 | Broder A Z Glassman S C Manasse M S | 1997 | Computer Networks and ISDN Systems1997，29，8： | 1 |
| 9 | Comparison of long-term outcomes of myomectomy and uterine artery embolization显示文摘 | Goodwin S Chen G | 2002 | Obstet Gynecol2002，100，51： | 1 |
| 10 | Network applications of Bloom filters: a survey显示文摘 | Broder A Mitzenmacher M | 2002 | Internet Mathematics2002，1，4： | 1 |
| 11 | Network applications of bloom fil - ters: A survey显示文摘 | Broder AMitzenmacher M | 2005 | Internet Mathematics2005，1，4： | 1 |
| 12 | Metal Reliability and validity of the Child Oral Health Impact Profile 显示文摘 | Broder HL Janal M Wilson-Genderson | 2005 | J Dent Res2005，，： | 1 |
| 13 | A PIV/PTV system for analyzing turbulent bubbly flow显示文摘 | Broder Sommerfeld M | 2000 | Experiments in fluids2000，，： | 1 |
| 14 | Experimental and numerical studies of the hydrodynamics in a bubble column 显示文摘 | Lain S Broder D Sommerfeld M | 1999 | Chemical Engineering Science1999，54，： | 1 |
| 15 | Granulomatous infectious diseases associated with tumor necrosis factor antagonists显示文摘 | Wallis R S Broder M S Wong J Y | | 0，，09： | 1 |
| 16 | Syntactic clustering of the web显示文摘 | Broder A Z Steven C G Mark S M | 1997 | Computer Networks and ISDN Systems Archive1997，29，8： | 1 |
| 17 | Determinants of Teaching Quality: what's Important to Students 显示文摘 | Broder J M Dorfmao J H | 2006 | Research in High Education2006，，35： | 1 |
| 18 | Infiltrating benign lipomas of the extremities显示文摘 | Regan M J Bickel WH Broders AC | 1946 | Surg Gynecol Obstet1946，54，： | 1 |
| 19 | Network Applications of Bloom Filters:A Survey显示文摘 | Broder A Mitzenmacher M | 2003 | Internet Mathematics2003，4，1： | 1 |
| 20 | Network applications of Bloom filters: a survey显示文摘 | BRODER A Z MITZENMACHER M | 2004 | Interact Mathematics2004，1，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员