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5篇 您的检索式：作者名="Brooks Keith"

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		题名	作者	年代	出处	被引量
	1	Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism.	Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis	2008	World Journal of Gastroenterology2008，14，9：	12
	2	The Effect of Hepatic Vascular Inflow Occlusion on Liver Tissue pH, Carbon Dioxide, and Oxygen Partial Pressures: Defining the Optimal Clamp/Release Regime for Intermittent Portal Clamping显示文摘	Adam J. Brooks John S. Hammond Keith Girling Ian J. Beckingham	2007	Journal of Surgical Research2007，，2：	1
	3	Acute and repeated dose (28 day) mouse oral toxicology studies with Cry34Ab1 and Cry35Ab1 Bt proteins used in coleopteran resistant DAS-59122-7 corn显示文摘	Daland R. Juberg Rod A. Herman Johnson Thomas Keith J. Brooks Bryan Delaney	2009	Regulatory Toxicology and Pharmacology2009，，2：	1
	4	Vegetative and floral shoot development of Zantedeschia ‘Black Magic'显示文摘	HALLIGAN ELIZABETH A BROOKING IAN R FUNNELL KEITH A	2004	Scientia Horticulturae2004，99，1：	1
	5	Mesoporous Nb2O5 Films: Influence of Degree of Crystallinity on Properties显示文摘	Lenzmann Frank Shklover Valery Brooks Keith	2000	Journal of Sol-Gel Science and Technology2000，19，：	1

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