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| 1 | P2X7 receptor signaling during adult hippocampal neurogenesis显示文摘Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus.Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new memories.Regulation of hippocampal neurogenesis is complex and multifaceted,and numerous signaling pathways converge to modulate cell proliferation,apoptosis,and clearance of cellular debris,as well as synaptic integration of newborn immature neurons.The expression of functional P2X7 receptors in the central nervous system has attracted much interest and the regulatory role of this purinergic receptor during adult neurogenesis has only recently begun to be explored.P2X7 receptors are exceptionally versatile:in their canonical role they act as adenosine triphosphate-gated calcium channels and facilitate calcium-signaling cascades exerting control over the cell via calcium-encoded sensory proteins and transcription factor activation.P2X7 also mediates transmembrane pore formation to regulate cytokine release and facilitate extracellular communication,and when persistently stimulated by high extracellular adenosine triphosphate levels large P2X7 pores form,which induce apoptotic cell death through cytosolic ion dysregulation.Lastly,as a scavenger receptor P2X7 directly facilitates phagocytosis of the cellular debris that arises during neurogenesis,as well as during some disease states.Understanding how P2X7 receptors regulate the physiology of stem and progenitor cells in the adult hippocampus is an important step towards developing useful therapeutic models for regenerative medicine.This review considers the relevant aspects of adult hippocampal neurogenesis and explores how P2X7 receptor activity may influence the molecular physiology of the hippocampus,and neural stem and progenitor cells. | Hannah C. Leeson Tailoi Chan-Ling Michael D. Lovelace Jeremy C. Brownlie Ben J. Gu Michael W. Weible II | 2019 | Neural Regeneration Research2019，14，10： | 3 |
| 2 | Oral DNA vaccination in utero induces mucosal immunity and immune memory in the neonate 显示文摘 | Gerdts V Snider-M Brownlie R | 2002 | J Immunol2002，168，4： | 1 |
| 3 | Diffusion Bonded Composite of YAG Single Crystals显示文摘 | Lee H C Brownlie P L Meissner H E | 1991 | SPIE1991，1624，： | 1 |
| 4 | Positional cloning of zaberfish ferroportin 1 identifies a conserved vertebrate iron exporter显示文摘 | Brownlie A | 2000 | Nature2000，403，6771： | 1 |
| 5 | Preliminary characterization of novel amino acid based polymeric vesicles as gene and drug delivery agents 显示文摘 | BROWN M D SCHATZLEIN A BROWNLIE A | 2000 | Bioconjug Chem2000，11，6： | 1 |
| 6 | Positional cloning of zebrafish ferroportinl identifies a conserved vertebrate iron exporter显示文摘 | Donovan A Brownlie A Zhou Yi | 2000 | Nature2000，403，6771： | 1 |
| 7 | Expression of mucosal chemokines TECKlCC125 and MEC/CC128 during fetal development of the ovine mucosal immune system 显示文摘 | Meurens F Whale J Brownlie R | 2007 | Immunology2007，120，4： | 1 |
| 8 | Positional cloning of zebrafish ferroportinl identifies a conserved vertebrate iron exporter显示文摘 | Donovan A Brownlie A Zhou Y | 2000 | Nature2000，403，6771： | 1 |
| 9 | Preliminary charaterization novel amino acid based polymeric vesicles as gene and drug delivery agents显示文摘 | Brown M D Schatzlein A Brownlie A | | 0，，： | 1 |
| 10 | The placental transfer of propylthiouracil, methimazole and carbimazole 显示文摘 | MARCHANT B BROWNLIE B E HART D M | 1977 | Clin Endocrinol Metab1977，45，6： | 1 |
| 11 | Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of cpg oligodeoxynucleotides显示文摘 | Brownlie R Zhu J Allan B and 3 others | | 0，，15： | 1 |
| 12 | Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides显示文摘 | Robert Brownlie Jianzhong Zhu Brenda Allan George K. Mutwiri Lorne A. Babiuk Andrew Potter Philip Griebel | 2009 | Molecular Immunology2009，，15： | 1 |
| 13 | Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women显示文摘 | BROWNLIE T 4th UTERMOHLEN V HINTON P S | 2004 | Am J Clin Nutr2004，79，3： | 1 |
| 14 | Iron supplementation improves endurance after training in iron- depleted, nonanemic women显示文摘 | HINTON P S GIORDANO C BROWNLIE T | 2000 | J Appl Physiol2000，88，3： | 1 |
| 15 | Treatment of murine collagen induced arthritis by the stress protein BIP via interleukin 4 producing regulatory T cells:A novel function for an ancientprotein显示文摘 | Brownlie RJ Myers LK Woley PH | 2006 | Arthritis Rheum2006，54，： | 1 |
| 16 | Distinguishing some approaches to translation research: The issue of interpretative constraints 显示文摘 | Brownlie S | 2003 | The Translator2003，9，1： | 1 |
| 17 | Expression of muco- sal chemokines TECK/CCL25 and MEC/CCL28 during fetal development of the ovine mucosal immune system显示文摘 | Meurens F Whale J Brownlie R etal | 2007 | Immu- nology2007，120，： | 1 |
| 18 | Situating discourse on translation and conflict 显示文摘 | Brownlie S | 2007 | Social Semiotics2007，17，2： | 1 |
| 19 | Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women 显示文摘 | BROWNLIE T 4th UTERMOHLEN V HINTON P S | 2002 | Am J Clin Nutr2002，75，4： | 1 |
| 20 | Avian Toll-like receptors 显示文摘 | Brownlie R Allan B | 2011 | Cell Tissue Res2011，343，1： | 1 |
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