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| 1 | Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na_2) solution for catheter locks显示文摘A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP. | Anne-Sophie Fiolet Elise Jandot Pauline Doucey Coralie Crétet Célia Brunel Christine Pivot Jean-Marc Ghigo Christophe Beloin David Lebeaux Fabrice Pirot | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 2 |
| 2 | Stent-assisted coiling of complex middle cer ebral artery aneurysms: initial and midterm results显示文摘 | Vendrell J F Costalat V Brunel H Riquelme C Bonafe A | 2011 | AJNR Am J Neuroradiol2011，32，： | 1 |
| 3 | Cytomegalovirus (CMV) and acute myocarditis in an immunoeompetent patient 显示文摘 | Roubille C Brunel AS Gahide G | 2010 | Intern Med2010，49，： | 1 |
| 4 | Phenotypic diversity and association mapping for fruit quality traits in cultivated tomato and related species显示文摘 | Xu J X Nicolas R Mu(n)os S Rolland S Bouchet J P Desplat N Paslier M C Le Liang Y Brunel D Causse M | | 0，，3： | 1 |
| 5 | Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir显示文摘 | Brunelle MN Jaequard AC Pieboud C | | 0，，07： | 1 |
| 6 | Use of stable isotopes of water to determine the origin of water used by the vegetation and to partition evapotranspiration: A case study from HAPEX-Sahel显示文摘 | Brunel J P Walker G R Dighton J C | 1997 | Journalof Hydrology1997，，： | 1 |
| 7 | Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir 显示文摘 | Brunelle MN Jacquard AC Pichoud C | 2005 | Hepatology2005，41，： | 1 |
| 8 | Phase Ⅱ study of first-line LY231514 (multi-targeted antifolate) in patients with locally advanced or metastatic colorectal cancer:An NC IC Clinical Trials Group study显示文摘 | CRIPPS C BRUNELL M JOLIVET J | 1999 | Ann Oncol1999，10，10： | 1 |
| 9 | High-frequency and - field election paramagnetic resonance of high-spin manganese(M) in tetrapyrrole complexes 显示文摘 | Krzystek J Pardi L A Brunel L C | 2002 | Spectrochim Acta A2002，58，： | 1 |
| 10 | Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattle 显示文摘 | BRUNELLE B W GREENLEE J J SEABURY C M | 2008 | BMC Veterinary Research2008，4，： | 1 |
| 11 | Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus ,Bos indicus ,and composite cattle 显示文摘 | Brunelle B W Greenlee J J Seabury C M | 2008 | BMC Vet Res2008，4，： | 1 |
| 12 | Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway 显示文摘 | Lee V Y Schroedl C Brunelle J K | 2005 | Am J Physiol Lung Cell Mol Physiol2005，289，4： | 1 |
| 13 | Chemotactic arrangement of axons inside and distal to a venous graft显示文摘 | Brunel i G Fontana G Jager C | | 0，，02： | 1 |
| 14 | 20th century sedi ment budget trends on the Western Gulf of Lions shoreface (France): An application of an integrated method for the study of sediment coastal reservoirs显示文摘 | Brunel C Certain R Sabatier F | 2014 | Geomorphology2014，204，： | 1 |
| 15 | A z - year clinical evaluation of a dipheny phosphorylazide - cross - linded collagen membrane for the treatment of buccal gingival recession 显示文摘 | Zahedi S Bozon C Brunel G | 1998 | Periodontol1998，69，9： | 1 |
| 16 | Is the implicit association test a valid and valuable measure of implicit consumer social cognition?显示文摘 | Brunel F F Tietje B C Greenwald A G | 2004 | Journal of consumer psychology2004，，4： | 1 |
| 17 | Mesozoic and Cenozoic tectonics of the northern edge of the Tibetan Plateau: Fission track constraints显示文摘 | Jolivet M Brunel M Seward D Xu Z Yang J Roger F Tapponnier P Malavieille J Arnaud N Wu C | 2001 | Tectonophysics2001，343，12： | 1 |
| 18 | Release of Ferulic Acid from Agroindustrial by-products by the Cell Wall-degrading Enzymes Produced by Aspergillus niger I-1472显示文摘 | Estelle Bonnin Luc Saulnier Magali Brunel C é cile Marot Laurence Lesage-Meessen Marcel Asther Jean-Franois Thibault | 2002 | Enzyme and Microbial Technology2002，，31： | 1 |
| 19 | Synthesis and antifungal activity of cholesterol-hydrazone derivatives显示文摘 | Loncle C Brunel J M Vidal N | 2004 | Euro J Med Chem2004，，49： | 1 |
| 20 | Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway显示文摘 | Lee VY Schroedl C Brunelle JK | 2005 | Am J Physiol Lung Cell Mol Physiol2005，289，4： | 1 |
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