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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Credibility of rules and economic growth: Evidence from a worldwide survey of the private sector显示文摘 | Brunetti A Kisunko G Weder B | 1998 | World Bank Economic Review1998，12，3： | 1 |
| 3 | Pituitary mi- croadenomas: a PET study 显示文摘 | De Souza B Brunetti A Fulham M J | 1990 | Radiology1990，177，1： | 1 |
| 4 | Amperometric Detection of Carbohydrates and Thiols by Using a Glassy Carbon Electrode Coated with Co Oxide/Multi-wall Carbon Nanotubes Catalytic System显示文摘 | Buratti S Brunetti B Mannino S | 2008 | Talanta2008，76，2： | 1 |
| 5 | Application of an improved glucuronidase assay method to the study of human blood B-glucuronidase显示文摘 | FISHMAN WH SPRINGER B BRUNETTI R | 1948 | J Biol Chem1948，256，： | 1 |
| 6 | Angular artery perforator flap for reconstruction of nasal sidewall and medial canthal defects 显示文摘 | Brunetti B Tenna S Aveta A | 2012 | Plast Reconstr Surg2012，130，4： | 1 |
| 7 | Effects of cocaine-and amphetamine-regulated transcript peptide,leptin and orexins on hypothalamic serotonin release显示文摘 | Orlando G Brunetti L Michelotto B | 2001 | Eur J Pharmacol2001，430，： | 1 |
| 8 | A feature-based approach towards an integrated product model including conceptual design information 显示文摘 | Brunetti G Golob B | 2000 | Computer-Aided Design2000，32，： | 1 |
| 9 | Identification of 8-iso-prostaglandin F(2alpha)in rat brain neuronal endings:a possiblemarker of membrane phospholipid peroxidation显示文摘 | Brunetti L Orlando G Michelotto B | 2002 | Life Sci2002，71，20： | 1 |
| 10 | A feature-based approach towards an integrated product model including conceptual design information显示文摘 | Brunetti G Golob B | 2000 | Computer-Aid- ed Design2000，32，14： | 1 |
| 11 | Pituitary microadenomas : A PET study 显示文摘 | Souza B Brunetti A Fulham MJ | 1990 | Radiology1990，177，： | 1 |
| 12 | A feature-based approach towards an integrated product model including conceptual design information显示文摘 | BRUNETTI G GOLOB B | 2000 | Computer-Aided Design2000，32，14： | 1 |
| 13 | A feature-based approach towards an integrated product model including conceptual design information显示文摘 | Brunetti G Golob B | 2000 | Computer-Aided Design2000，32，： | 1 |
| 14 | A feature-based approach towards an integrated product model including conceptual design information显示文摘 | Brunetti G Golob B | 2000 | Computer-Aided Design2000，32，： | 1 |
| 15 | Mass spectrometric study of double photoionization of HBr molecules显示文摘 | Alagia M Boustimi M Brunetti B G | 2002 | Journal of Chemical Physics2002，117，： | 1 |
| 16 | A feature-based approach towards an in- tegrated product model including conceptual design informa- tion显示文摘 | Brunetti G Golob B | 2000 | Computer Aided Design2000，32，： | 1 |
| 17 | Identifica- tion of 8-iso-prostaglandin F (2alpha) in rat brain neu- ronal endings: a possible marker of membrane phos- pholipid peroxidation 显示文摘 | Brunetti L Orlando G Michelotto B | 2002 | Life Sci2002，71，20： | 1 |
| 18 | Failure of repeated treat- ment with praziquantel and arthemeter in four patients with acute schistosomiasis 显示文摘 | Pratico L Mariani B Brunetti E | 2014 | J Travel Med2014，21，2： | 1 |
| 19 | A-feature-based approach towards an integrated product including conceptual design information 显示文摘 | BRUNETTI G GOLOB B | 2000 | Computer-Aided Design2000，32，： | 1 |
| 20 | A free press is bad news for corruption 显示文摘 | Brunetti A Weder B | 2003 | Journal of Public Economics2003，87，： | 1 |
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