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| 1 | Long-acting anticoagu- lant overdose: brodifacoum kinetics and optimal Vitamin K dosing 显示文摘 | Bruno GR Howland MA McMeeking A | 2000 | Ann Emerg Med2000，36，： | 1 |
| 2 | Factors predictive of acute renal failure and need for hemodialysis among ED patients with rhabdomyolysis显示文摘 | Fernandez WG Hung O Bruno GR | 2005 | Am J Emerg Med2005，23，1： | 1 |
| 3 | Dual stem cell therapy after myocardial infarction acts specifically by enhanced homing via the SDF-1/CXCR4 axis显示文摘 | Hans D. Theiss Markus Vallaster Christoph Rischpler Lisa Krieg Marc-Michael Zaruba Stefan Brunner Yordan Vanchev Rebekka Fischer Michael Gr?bner Bruno Huber Timm Wollenweber Gerald Assmann Josef Mueller-Hoecker Markus Hacker Wolfgang-M. Franz | 2011 | Stem Cell Research2011，，3： | 1 |
| 4 | Long-acting antlco- agulant overdose: brodifacoum kinetics and optimal vitamin K closing 显示文摘 | Bruno GR Howland MA McMeeking A | 2000 | Ann Enmrg Med2000，36，3： | 1 |
| 5 | Long-act-ing anticoagulant overdose : brodifacoum kinetics and opti-mal vitamin K dosing显示文摘 | Bruno GR Howland MA Mcmeeking A | 2000 | Ann Emerg Med2000，36，3： | 1 |
| 6 | Pharmacokinetics/pharmacodynamics in drug development:an industrial perspective显示文摘 | Chaikin P Rhodes GR Bruno R | 2000 | J Clin Pharmacol2000，40，122： | 1 |
| 7 | Long acting anticoagtllant overdose brodifaeoum netic8 and optimal vitamin K dosing 显示文摘 | Bruno GR Howland MA McMeeking A | 2000 | Ann Emerg Med2000，36，： | 1 |
| 8 | Factors predictive of acute renal failure and need for hemodialysis among ED patients with rhabdomyolysis显示文摘 | Fernandez WG Hung O Bruno GR | 2005 | Am J Emerg Med2005，23，1： | 1 |
| 9 | Factors predictive of acute renal failure and need for hemodialysis among ED patients with rhabdomyolysis显示文摘 | Fernandez WG Hung O Bruno GR | 2005 | Am J Emerg Med2005，23，1： | 1 |
| 10 | Factors predictive of acute renal failure and need for hemodialysis among ED patients with rhabdomyolysis 显示文摘 | Fernandez WG Hung O Bruno GR | 2005 | Am J Emerg Med2005，23，1： | 1 |
| 11 | Factors predictive of acute renal failure and need for hemodialysis among ED patients with rhabdomyolysis显示文摘 | Fernandez WG Hung O Bruno GR | 2005 | Am J Emerg Med2005，23，1： | 1 |
| 12 | Long-acting anticoagulant overdose: brodifacoum kinetics andoptimal vitamin K dosing显示文摘 | Bruno GR Howland MA Mcmeeking A | 2000 | Ann Emerg Med2000，36，3： | 1 |
| 13 | Factors predictive of acute renal failure and need for hemodialysis among ED patients with rhabdomyolysis显示文摘 | Fernandez WG Hung O Bruno GR | 2005 | Am J Emerg Med2005，23，1： | 1 |
| 14 | Pharmacokinetics/pharmacodynamics in drug development:an industrial perspective显示文摘 | Chaikin P Rhodes GR Bruno R | 2000 | J Clin Pharmacol2000，40，： | 1 |
| 15 | Long-acting anticoagulant overdose : brodifacoum kinetics and optimal vitamin K dosing 显示文摘 | Bruno GR Howland MA McMeeking A | 2000 | Ann Emerg Med2000，36，3： | 1 |
| 16 | Factors predictive of acute renal failure and need for hemodialysis among ED patients with rhabdom-yolysis显示文摘 | Femandez WG Hung O Bruno GR | 2005 | Am J Emerg Med2005，23，1： | 1 |
| 17 | Long acting anticoagulant overdose : brodifacoum kinetics and optimal vitamin K dosing 显示文摘 | Bruno GR Howland MA McMeeking A | 2000 | Ann Emerg Med2000，36，： | 1 |
| 18 | A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers显示文摘Background The identification of circulating biomarkers that closely correlate with Parkinson’s Disease(PD)has failed several times in the past.Nevertheless,in this pilot study,a translational approach was conducted,allowing the evaluation of the plasma levels of two mitochondrial-related proteins,whose combination leads to a robust model with potential diagnostic value to discriminate the PD patients from matched controls.Methods The proposed translational approach was initiated by the analysis of secretomes from cells cultured under control or well-defined oxidative stress conditions,followed by the identification of proteins related to PD pathologic mechanisms that were altered between the two states.This pipeline was further translated into the analysis of undepleted plasma samples from 28 control and 31 PD patients.Results From the secretome analysis,several mitochondria-related proteins were found to be differentially released between control and stress conditions and to be able to distinguish the two secretomes.Similarly,two mitochondrial-related proteins were found to be significantly changed in a PD cohort compared to matched controls.Moreover,a linear discriminant model with potential diagnostic value to discriminate PD patients was obtained using the combination of these two proteins.Both proteins are associated with apoptotic mitochondrial changes,which may correspond to potential indicators of cell death.Moreover,one of these proteins,the VPS35 protein,was reported in plasma for the first time,and its quantification was only possible due to its previous identification in the secretome analysis.Conclusions In this work,an adaptation of a translational pipeline for biomarker selection was presented and transposed to neurological diseases,in the present case Parkinson’s Disease.The novelty and success of this pilot study may arise from the combination of:i)a translational research pipeline,where plasma samples are interrogated using knowledge previously obtained from the evaluation of cells’secretome under oxidative stress;ii)the combined used of statistical analysis and an informed selection of candidates based on their link with relevant disease mechanisms,and iii)the use of SWATH-MS,an untargeted MS method that allows a complete record of the analyzed samples and a targeted data extraction of the quantitative values of proteins previously identified. | Sandra I.Anjo Patrícia Valério dos Santos Luiza Rosado Graça Baltazar Inês Baldeiras Diana Pires Andreia Gomes Cristina Januário Miguel Castelo-Branco Mário Grãos Bruno Manadas | 2020 | Translational Neurodegeneration2020，9，2： | 0 |
| 19 | Definition of candidate Essential Variables for the monitoring of mineral resource exploitation显示文摘The practice of raw material extraction has a high impact on the environment and represents a potential threat to the health and thriving of local communities.The concept of Extractive Essential Variables(EEVs)are explored in order to propose variables that can be used to quantify the environmental footprint of mineral extraction.Considering the interdependence of mining activities with social,economic and environmental issues,the variables target the development of monitoring tools for the implementation of the Sustainable Development Goals(SDGs).The identification of EEVs is based on the use of Earth Observation products in the field of mineral resources exploitation.A list of variables is proposed based on three classes of Essential Variables(EVs):installation and exploration phase,mineral extraction,and ore processing.These variables take into account the impacts of mining on the hydrology,land,water resources and the atmosphere of the area subjected to mineral exploitation.One of the variables is implemented as an operational workflow addressing SDG15,“life on land”.The workflow is intended to assess the area of forest ecosystem lost due to the presence of a mining site.Geospatial data on the extent of mining concessions and forest cover are combined using ArcGIS^(TM).The workflow is successively translated into a Unix script to automatize the process of data treatment.The script is developed using the Geospatial Data Abstraction Library(GDAL).The use of a Virtual Laboratory Platform(VLab),a web-service-based access platform,increases the accessibility of data and resources and the re-use of the script.This work is a first attempt to propose a framework of EEVs,derived data workflows,while the underlying methodology,partially based on scientific publications and on personal reasoning,still needs to be tested and,improved based on expertise in the sector. | Mariapaola Ambrosone Grégory Giuliani Bruno Chatenoux Denisa Rodila Pierre Lacroix | 2019 | Geo-Spatial Information Science2019，22，4： | 0 |
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