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| 1 | Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians显示文摘Pancreatic cancer(PC) would become the second leading cause of cancer death in the near future, despite representing only 3% of new cancer diagnosis. Survival improvement will come from a better knowledge of risk factors, earlier diagnosis, better integration of locoregional and systemic therapies, as well as the development of more efficacious drugs rising from a deeper understanding of disease biology. For patients with unresectable, non-metastatic disease, combined strategies encompassing primary chemotherapy and radiation seems to be promising. In fit patients, new polychemotherapy regimens can lead to better outcomes in terms of slight but significant survival improvement associated with a positive impact on quality of life. The upfront use of these regimes can also increase the rate of radical resections in borderline resectable and locally advanced PC. Second line treatments showed to positively affect both overall survival and quality of life in fit patients affected by metastatic disease. At present, oxaliplatin-based regimens are the most extensively studied. Nonetheless, other promising drugs are currently under evaluation. Presently, in addition to surgery and conventional radiation therapy, new locoregional treatment techniques are emerging as alternative options in the multimodal approach to patients or diseases not suitable for radical surgery. As of today, in contrast with other types of cancer, targeted therapies failed to show relevant activity either alone or in combination with chemotherapy and, thus, current clinical practice does not include them. Up to now, despite the fact of extremely promising results in different tumors, also immunotherapy is not in the actual therapeutic armamentarium for PC. In the present paper, we provide a comprehensive review of the current state of the art of clinical practice and research in PC aiming to offer a guide for clinicians on the most relevant topics in the management of this disease. | Rosella Spadi Federica Brusa Agostino Ponzetti Isabella Chiappino Nadia Birocco Libero Ciuffreda Maria Antonietta Satolli | 2016 | World Journal of Clinical Oncology2016，7，1： | 15 |
| 2 | Levodopa improves time-based prospective memory in Parkinson's disease显示文摘 | Costa A Peppe A Brusa L | 2008 | J Int Neuropsychol Soc2008，14，4： | 1 |
| 3 | Total cross sections for positron scattering on argon and krypton atintermediate and high energies 显示文摘 | Karwasz G P Barozzi M Brusa R S Zecca A | 2002 | Nuclear Instruments and Methods in Physics Research2002，192，： | 1 |
| 4 | Prepartion, characterization, cytotoxicity and pharmacokinetics of liposomes ontaining docetaxel 显示文摘 | IMMORDINO M L BRUSA P ARPICCO S | 2003 | J Controlled Release2003，91，4： | 1 |
| 5 | Absolute radiometers(PMO6) and their experimental characterization显示文摘 | Brusa R W Frhlich C | 1986 | Applied optics1986，25，22： | 1 |
| 6 | The weekend and ' re- verse' weekend effects :an analysis by month of the year, week of the month, and industry 显示文摘 | BRUSA J LIU P SCHULMAN C | 2003 | Journal of Business Finance & Accounting2003，30，6： | 1 |
| 7 | Academic Content, Research Productivity, and Tenture显示文摘 | Jorge Brusa | 2010 | J Econ2010，，2010： | 1 |
| 8 | Preparation, characterization and properties in vitro and in vivo of paclitaxel-albumin conjugate显示文摘 | Dosio F Brusa P Crosasso P | 1997 | J Controlled Release1997，47，3： | 1 |
| 9 | Study on the microbiological degradation of bensulfuronmethyl 显示文摘 | Brusa T Ferrari F Bolzacehini E | 2001 | Annals of Microbiology2001，51，： | 1 |
| 10 | Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing docetaxel 显示文摘 | IMMORDINO M L BRUSA P ARPICCO S | 2003 | J Control Release2003，91，3： | 1 |
| 11 | preparation,characterization cytotxicity and pharmacokinetics of liposomes containininglipophilic gemcitabine prodrugs显示文摘 | Maria Janra Brusa Paolaetal | 2004 | Journal of Controlled Release2004，100，3： | 1 |
| 12 | Numerical and experimental analysis of the dynamic effects in compact cluster mills for cold rolling显示文摘 | Eugenio Brusa Luca Lemma | 2008 | Journal of Materials Processing Tech2008，，5： | 1 |
| 13 | Immunotoxins and anti- cancer drug conjugate assemblies:the role of the linkage between components 显示文摘 | DOSIO F BRUSA P CATTRL L | 2011 | Toxins ( Basel )2011，3，7： | 1 |
| 14 | Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes显示文摘 | Crosasso P Ceruti M Brusa P | 2000 | Journal of Control Release2000，63，： | 1 |
| 15 | Is there a prognostic role for C-reactive protein in ischemic stroke?显示文摘 | Corso G Bottacchi E Brusa A | 2010 | Acta Neurol Scand2010，122，： | 1 |
| 16 | Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing docetaxel显示文摘 | IMMORDINO M L BRUSA P ARPICCO S | 2003 | J Controlled Release2003，91，3： | 1 |
| 17 | Preparation,characterization,cytotoxicity and pharmaceutics of liposomes containing docetaxel显示文摘 | Immordino ML Brusa P Arpicco S | 2003 | J Control Release2003，91，3： | 1 |
| 18 | Blood C-reactive protein concentration with ABCD (2) is a better prognostic tool than ABCD (2) alone 显示文摘 | Corso G Bottacchi E Brusa A | 2011 | Cerebrovasc Dis2011，32，2： | 1 |
| 19 | Positron annihilation in B-doped and undoped single and polycrystalline Ni 3 Al alloys显示文摘 | Wen Deng Y.Y. Huang R.S. Brusa G.P. Karwasz A. Zecca | 2005 | Journal of Alloys and Compounds2005，，1： | 1 |
| 20 | Interleukin 10 modulates neuronal threshold of vulnerability to ischaemic damage显示文摘 | Grilli M Barbieri I Basudev H Brusa R Casati C Lozza G Ongini E | 2000 | Eur J Neurosei2000，12，7： | 1 |
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