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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Application of polynomial chaos on numerical simulation of stochastic cavity flow显示文摘In present paper,the mathematic background of intrusive polynomial chaos (IPC) method and coupling process with one dimension Euler equation were introduced. The IPC method was implemented for the 2D compressible stochastic Navier-Stokes equations to simulate the non-deterministic behavior of a lid driven cavity flow under the influence of uncertainties. The driven velocity and fluid viscosity were supposed respectively to be the uncertain variable which has Gaussian probability distribution. Based on the validation with benchmark results,discussions were mainly focused on the statistic properties of velocity distribution. The results indicated the effect of IPC method on the simulation of propagation of uncertainty in the flow field. For the simulated results of 2D cavity flow,influence of the driven velocity uncertainty is larger than that of viscosity. | WANG XiaoDong1,2 & KANG Shun1 1 Key Laboratory of Condition Monitoring and Control for Power Plant Equipment, Ministry of Education, School of Energy Power and Mechanical Engineering, North China Electric Power University, Beijing 102206, China 2 Department of Mechanical Engineering, Vrije Universiteit Brussel, Brussels 1050, Belgium | 2010 | Science China(Technological Sciences)2010，53，10： | 9 |
| 3 | Diagnosis and treatment of gastroesophageal reflux disease in infants and children显示文摘 | Yvan Vandenplas(PhD.,Academic Children’s Hospital,Free University of Brussels,Laarbeeklaan 101) | 1999 | World Journal of Gastroenterology1999，5，5： | 7 |
| 4 | A Rapid and Cost-Effective Method for Genotyping Genome-Edited Animals:A Heteroduplex Mobility Assay Using Microfluidic Capillary Electrophoresis显示文摘The recent emergence and application of engineered endonucleases have led to the development of genome editing tools capable of rapidly implementing various targeted genome editions in a wide range of species.Moreover,these novel tools have become easier to use and have resulted in a great increase of applications.Whilst gene knockout(KO) or knockin(KI) animal models are relatively easy to achieve,there is a bottleneck in the detection and analysis of these mutations.Although several methods exist to detect these targeted mutations,we developed a heteroduplex mobility assay on an automated microfluidic capillary electrophoresis system named HMA-CE in order to accelerate the genotyping process.The HMA-CE method uses a simple PCR amplification of genomic DNA(gDNA) followed by an automated capillary electrophoresis step which reveals a heteroduplexes(HD) signature for each mutation.This allows efficient discrimination of wild-type and genome-edited animals down to the single base pair level. | Vanessa Chenouard Lucas Brusselle Jean-Marie Heslan Séverine Remy Séverine Ménoret Claire Usal Laure-Hélène Ouisse Tuan Huy NGuyen Ignacio Anegon Laurent Tesson | 2016 | Journal of Genetics and Genomics2016，43，5： | 4 |
| 5 | Reconfiguable manufacturing systems显示文摘 | Koren Y Heisel U Jovane F Mofiwaki T Pritchow G Ulsoy G Van Brussel H | 1999 | Annals of the CIRP1999，48，2： | 1 |
| 6 | Accurate tracking control of linear synchronous motor machine tool axes 显示文摘 | Braembussche P V Swevers J Brussel H V | 1996 | Mechatronics1996，6，5： | 1 |
| 7 | Influence of adhesive wear and thermal degradation on the frictional characteristics of paper-based friction materials : a comparative study 显示文摘 | Ompusunggu A P Sas P Van Brussel H | 2013 | ISRN Tribology2013，2013，： | 1 |
| 8 | Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice显示文摘 | Brusselle GJ Joos GF | 1996 | Am J Respir Cirt Care Med1996，153，2： | 1 |
| 9 | Dendritic cells in chronic obstructive pulmonary disease: new players in an old game 显示文摘 | Tsoumakidou M Demedts IK Brusselle GG | 2008 | Am J Respir Crit Care Med2008，177，： | 1 |
| 10 | Elevated MMP - 12 protein levels in induced sputum from patients with COPD 显示文摘 | Demedts I K Morel - Montero A Lebecque S Pacheco Y Cataldo D Joos G F Pauwels R A Brusselle G G | 2006 | Thorax2006，61，6： | 1 |
| 11 | Allergen induced airway inflamma- tion and bronchial responsiveness in wildtype and interleukin - 4 - de- ficient mice 显示文摘 | Brusselle G Kips J Joos G | 1995 | Am J Respir Cell Mol Biol1995，12，4： | 1 |
| 12 | New insights into the immunol- ogy of chronic obstructive pulmonary disease 显示文摘 | Brusselle GG Joos GF Bracke KR | 2011 | Lancet2011，1，9795： | 1 |
| 13 | New insights into the immunology of chronic obstructive pulmonary disease显示文摘 | Brusselle GG Joos GF Bracke KR | 2011 | Lancet2011，，378： | 1 |
| 14 | LFTs for automotive appli- cations显示文摘 | Henning F Ernst H Brussel R | 2005 | Reinforced plastics2005，49，2： | 1 |
| 15 | Modeling of the Dynamic Behavior of Systems with Rolling Elements显示文摘 | De Moerlooze K A1-Bender F Van Brussel H | 2011 | International Journal of Non- linear Mechanics2011，46，1： | 1 |
| 16 | Spatial Preference Modelling for equitable infrastructure provision: an application of Sen’s Capability Approach显示文摘 | Arif Wismadi Mark Zuidgeest Mark Brussel Martin Maarseveen | 2014 | Journal of Geographical Systems2014，，1： | 1 |
| 17 | Murine models of COPD显示文摘 | G.G. Brusselle K.R. Bracke T. Maes A.I. D’hulst K.B. Moerloose G.F. Joos R.A. Pauwels | 2005 | Pulmonary Pharmacology & Therapeutics2005，，3： | 1 |
| 18 | Mild preoperative renal dysfunction as a predictor of long-term clinical outcome after coronary bypass surgery显示文摘 | van de Wal RMA van Brussel BL Voors AA | 2005 | J Thorac Cardiovasc Surg2005，29，2： | 1 |
| 19 | Towards a mechatronic compiler 显示文摘 | Van Brussel H Sas P Nemeth I | 2001 | Mechatronics IEEE/ASME Transactions on2001，6，1： | 1 |
| 20 | Cytokine manipulation in animal models of asthma显示文摘 | Brussele GJ Kips JC | 1997 | Am J Respir Crit Care Med1997，156，42： | 1 |
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