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| 1 | Overview of hepatitis B virus mutations and theirimplications in the management of infection显示文摘Hepatitis B virus(HBV)affects approximately two billion people worldwide and more than 240 million people in the world are currently chronic carrier that could develop serious complications in the future,like liver cirrhosis and hepatocellular carcinoma.Although an extended HBV immunization program is being carried out since the early‘80s,representing effective preventive measure,leading to a dramatic reduction of HBV hepatitis incidence,globally HBV infection still represents a major public health problem.The HBV virus is a DNA virus belongs to the Hepadnaviridae family.The HBV-DNA is a circular,partial double strand genome.All coding information is on the minus DNA strand and it is organized into four open reading frames.Despite hepatitis B virus is a DNA virus,it has a high mutation rate due to its replicative strategy,that leads to the production of many nonidentical variants at each cycle of replication.In fact,it contains a polymerase without the proofreading activity,and uses an RNA intermediate(pg RNA)during its replication,so error frequencies are comparable to those seen in retroviruses and other RNA viruses rather than in more stable DNA viruses.Due to the low fidelity of the polymerase,the high replication rate and the overlapping reading frames,mutations occur throughout the genome and they have been identified both in the structural and not structural gene.The arise of mutations being to develop of a whole of viral variants called'quasi-species'and the prevalent population,which favors virus replication,was selected by viral fitness,host’s immune pressure and external pressure,i.e.,vaccination or antiviral therapy.Naturally occurring mutations were found both in acute and chronic subjects.In the present review we examine and discuss the most recent available data about HBV genetic variability and its significance. | Patrizia Caligiuri Rita Cerruti Giancarlo Icardi Bianca Bruzzone | 2016 | World Journal of Gastroenterology2016，22，1： | 25 |
| 2 | Hepatitis C virus in the new era:Perspectives in epidemiology,prevention,diagnostics and predictors of response to therapy显示文摘Despite the great successes achieved in the fields of virology and diagnostics,several difficulties affect improvements in hepatitis C virus(HCV)infection control and eradication in the new era.New HCV infections still occur,especially in some of the poorest regions of the world,where HCV is endemic and long-term sequelae have a growing economic and health burden.An HCV vaccine is still no available,despite years of researches and discoveries about the natural history of infection and host-virus interactions:several HCV vaccine candidates have been developed in the last years,targeting different HCV antigens or using alternative delivery systems,but viral variability and adaption ability constitute major challenges for vaccine development.Many new antiviral drugs for HCV therapy are in preclinical or early clinical development,but different limitations affect treatment validity.Treatment predictors are important tools,as they provide some guidance for the management of therapy in patients with chronic HCV infection:in particular,the role of host genomics in HCV infection outcomes in the new era of direct-acting antivirals may evolve for new therapeutic targets,representing a chance for modulated and personalized treatment management,when also very potent therapies will be available.In the present review we discuss the most recent data about HCV epidemiology,the new perspectives for the prevention of HCV infection and the most recent evidence regarding HCV diagnosis,therapy and predictors of response to it. | Filippo Ansaldi Andrea Orsi Laura Sticchi Bianca Bruzzone Giancarlo Icardi | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 3 | A novel transductive SVM for semisupervised classification of remote-sensing images 显示文摘 | Bruzzone L Chi M M Marconcini M | 2006 | IEEE Transactions on Geoscience and Remote Sensing2006，44，11： | 1 |
| 4 | Learning the language of cell - cell communication through connexin channels 显示文摘 | Bruzzone R | 2001 | Genome Bid2001，2，11： | 1 |
| 5 | Detection of changes in remotely sensed images by the selective use of multi-spectral information显示文摘 | Bruzzone L Serpico S B | 1997 | International Journal of Remote Sensing1997，18，18： | 1 |
| 6 | A Detail-Preserving Scale- Driven Approach to Change Detection in Multitemporal SAR Images显示文摘 | Bovolo F Bruzzone L | 2005 | IEEE Transactions on Geoscience and Remote Sensing2005，43，12： | 1 |
| 7 | Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger显示文摘 | BRUZZONE S BODRATO N USAI C | 2008 | J Biol Chem2008，283，32： | 1 |
| 8 | An Unsupervised Approach Based on the Generalized Gaussian Model to Automatic Change Detection in Multitemporal SAR Images显示文摘 | BAZI Yakoub BRUZZONE Lorenzo MELGANI Farid | 2005 | IEEE Transactions on Geoscience and Remote Sensing2005，43，4： | 1 |
| 9 | A Contextsensitive Technique for Unsupervised Change Detection Based on Hopfield type Neural Networks显示文摘 | GHOSH S BRUZZONE L PATRA S | | 0，，03： | 1 |
| 10 | On the Relationship Between Double Bounce and the Ori- entation of Buildings in VHR SAR Images显示文摘 | FERRO A BRUNNER D BRUZZONE L | 2011 | IEEE Geoscienee and Remote Sensing Letters2011，8，4： | 1 |
| 11 | A CompositeSemi supervised SVM for Classification of Hyper spectral Images显示文摘 | Mattia Marconcini Gustavo Camps-Valls Lorenzo Bruzzone | 2009 | IEEE Geosciences and Remote Sensing Letters2009，6，2： | 1 |
| 12 | Classification of hyperspeetral remote sensing images with support vector machines 显示文摘 | MELGANI F BRUZZONE L | 2004 | IEEE Transactions' Geoscience and Rernote Sensing2004，42，8： | 1 |
| 13 | Semisupervised classification of hyperspectral images by SVMs optimized in the primal 显示文摘 | Chi M M Bruzzone L | 2007 | IEEE Transactions on Geoscience and Remote Sensing2007，45，6： | 1 |
| 14 | Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis显示文摘 | MAGNONE M BRUZZONE S GUIDA L | 2009 | J Biol Chem2009，284，17： | 1 |
| 15 | Combination hepatitis C virus antigen and antibody immunoassay as a new tool for early diagnosis of infection显示文摘 | Ansaldi F Bruzzone B Testino G | 2006 | J Viral Hepat2006，13，1： | 1 |
| 16 | Connections with connexins: the molecular basis of direct intercellular signaling显示文摘 | Bruzzone R White TW Paul DL | 1996 | Eur J Biochem1996，238，： | 1 |
| 17 | Introduction to the issue on advances in remote sensing image processing 显示文摘 | CAMPS-VALLS G BENEDIKTSSON J A BRUZZONE L | 2011 | IEEE Journal of Selected Topics in Signal Processing2011，5，3： | 1 |
| 18 | Evaluation of tibial rotational alignment in total kn arthroplasty- ca cadaver study显示文摘 | Rossi R Bruzzone M Botaasia DE | 2010 | Knee Surg Sports Traumatol Arthrosc2010，18，7： | 1 |
| 19 | Aniterative technique for the detection of land-cover transition inmulti- temporal remote sensing image显示文摘 | Bruzzone L | 1997 | Remote Sensing1997，35，4： | 1 |
| 20 | Classification of hyperspectral remote-sensing data with primal SVM for small-sized training dataset problem显示文摘 | Chi Mingmin Feng Rui Lorenzo Bruzzone | | 0，，11： | 1 |
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