|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells显示文摘尽管有非酒精的脂肪肝疾病是良性的混乱的起始的信仰,纤维变性前进发生在病人的一个重要数字,这现在被认出。而且,肝的脂肪变性在大量其它为肝的纤维变性的前进作为一个风险因素被识别了肝疾病。这里,我们建立了一在里面在肝的星形的房间(HSC ) 上学习肝的类脂化合物累积的效果的 vitro 模型,肝 fibrogenesis 的中央调停人。主要人的 hepatocytes 与浸透的丰满的酸 palmitate 被孵化导致细胞内部的类脂化合物累积。随后,人的 HSC 从 steatotic 或控制 hepatocytes 与调节媒介(厘米) 被孵化。在 hepatocytes 的类脂化合物累积导致了加速了 HSC 的激活和增长的因素的版本,并且提高了他们的抵抗到 apoptosis,大部分经由 PI-3-kinase 小径的激活调停了。而且,从 steatotic hepatocytes 的厘米导致了 profibrogenic 基因 TGF- 尾, metallo-proteinase-1 (TIMP-1 ) 的织物禁止者, TIMP-2 和 matrix-metallo-proteinase-2 的表示,以及在 HSC 的原子因素的魏 B 依赖者 MCP-1 表示。在摘要,我们的在里面 vitro 数据在 vivo 为在肝的脂肪变性和 fibrogenesis 之间的 pathophysiological 连接显示潜在的机制。附此,这研究提供一在 vitro 吸引人学习导致脂肪变性的 fibrogenesis 的分子的机制,并且识别并且测试小说的模型在脂肪肝为 antifibrotic 指向治疗疾病。 | Hella Wobser Christoph Dora Thomas S Weiss Thomas Amann Cornelius Bollheimer Roland Btittner Juergen Schoelmerich Claus Helterbrand | 2009 | Cell Research2009，19，8： | 16 |
| 2 | Exercise affects the gene expression profiles of human white blood cells 显示文摘 | Btittner P Moslg S Lechtermann A | 2007 | J Appl Physiol2007，102，： | 1 |
| 3 | A novel process to separate submicron particles from gases--a cascade of packed columns 显示文摘 | Heidenreich S Vogt U Btittner H | 2000 | Chemical Engineering Science2000，55，15： | 1 |
| 4 | Effect of ACE-inhibitor ramiprilat and AT1-receptor antagonist candesartan on cardiac nore- pinephrine release: comparison between ischemic and nonischemic conditions显示文摘 | Richardt D Wolfrum S Btittner C | 2002 | J Cardiovasc Pharmacol2002，，4： | 1 |
| 5 | A novel process to separate submicron particles from gases-a cascade of packed columns 显示文摘 | Heidenreich S Vogt U Btittner H | 2000 | Chemical EngineeringScience2000，55，15： | 1 |
| 6 | Apop- tosis in yeast: Triggers, pathways, subroutines 显示文摘 | Carmona-Gutierrez D Eisenberg T Btittner S | 2010 | Cell Death and Differentiation2010，17，： | 1 |
| 7 | A novel process to separate submicron particles from gases-a cascade of packed columns 显示文摘 | Heidenreich S Vogt U Btittner H | 2000 | Chemical Engineering Science2000，55，15： | 1 |
| 8 | A novel process to separate submicron particles from gases-a cascade of packed columns显示文摘 | Heidenreich S Vogt U Btittner H Ebert F | 2000 | Chemical Engineering Science2000，55，15： | 1 |
| 9 | An extensive study of droplet growth and separation of submicron particles in packed columns 显示文摘 | Vogt U Heidenreich S Btittner H | 1997 | Particle Technology & Fluid Mechanics1997，28，1： | 1 |
| 10 | Influence of libronic degrees of freedom on electronic properties of polyaniline 显示文摘 | Baranowski D Btittner H Voit J | 1992 | Phys Rev B1992，45，10： | 1 |
| 11 | Blue light phototherapy of neonatal jaundice does not increase the risk for melanocytic nevus development 显示文摘 | Bauer J Btittner P Luther H | 2004 | Arch Dermatol2004，14，4： | 1 |
| 12 | Hereditary nonpolyposis colorectal cancer ( HNPCC)/Lynch syndrome 显示文摘 | Steinke V Engel C Btittner R | 2013 | Dtsch Arztebl Int2013，110，3： | 1 |
| 13 | Is low dose haloperidol a useful antiemetic? A meta-analysis of published and unpublished randomized trials 显示文摘 | Btittner M Walder B Von Elm E | 2004 | Anesthesiology2004，101，6： | 1 |
| 14 | Spatial and temporal patterns of fine root abundance in a mixed oak-beech forest显示文摘 | Btittner V Leuschner C | | 0，，： | 1 |
| 15 | A novel process to separate submicron particles from gases-a cascade of packed columns显示文摘 | Heidenreich S Vogt U Btittner H | 2000 | Chemical Engineering Science2000，55，15： | 1 |
| 16 | Analysis of genomic rearrangement and subsequent gene deletion of the attenuated Orf virus strain D1701显示文摘 | Cottone R Btittner M Bauer B | 1998 | Virus Res1998，56，1： | 1 |
| 17 | Urinary levels of l-hydroxypyrene, 1-, 2-, 3-, and 4-hydroxyphenanthrene in females living in an industrial area of Germany 显示文摘 | Gondel J Mannschreck C Btittner K | 1996 | Archives of Environmental Contamination and Toxicology1996，31，4： | 1 |
| 18 | Arabidopsis thaliana ethylene-responsive element binding protein (AtEBP), an ethylene-inducible, GCC box DNA-binding protein interacts with an ocs element binding protein 显示文摘 | Btittner M Singh K B | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 19 | A novel process to separate submicron particles from gases-a cascade of packed columns显示文摘 | HEIDENREICH S VOGT U BTITTNER H EBERT F | 2000 | Chem Eng Sci2000，55，15： | 1 |
| 20 | Serum S100B, lactate debydrogenase and brain metastasis are prognostic factors in patients with distant melanoma metastasis and systemic therapy显示文摘 | Weide B Richter S Btittner P | 2013 | PLoS One2013，8，81： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员