|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 2 | Targeted conditional gene knockout in human embryonic stem cells显示文摘 | Lei Bu Xiaolin Gao Xin Jiang Kenneth R Chien Zhong Wang | 2010 | Cell Research2010，20，3： | 6 |
| 3 | In vivo gastric mucosal histopathology using endocytoscopy显示文摘AIM:To study the ability of endocytoscopy to identify normal gastric mucosa and to exclude Helicobacter pylori(H.pylori) infection.METHODS:Endocytoscopic examination of the gastric corpus and antrum was performed in 70 consecutive patients.Target biopsy specimens were also obtained from the assessed region and multiple H.pylori tests were performed.The normal endocytoscopy patterns of the corpus and antrum were divided into the normal pit-dominant type(n-Pit) or the normal papilladominant type(n-Pap), respectively characterized as either regular pits with capillary networks or round, smooth papillary structures with spiral capillaries.On the other hand, normal mucosa was defined as mucosa not demonstrating histological abnormalities, including inflammation and atrophy.RESULTS:The sensitivity and specificity of n-Pit for normal mucosa in the gastric corpus were 94.4%and 97.1%,respectively,whereas those of n-Pap for normal mucosa in the antrum were 92.0%and 86.7%,respectively.The positive predictive values of n-Pit and n-Pap for H.pylori-negative tissue were 88.6%and 93.1%,respectively,and their negative predictive values for H.pylori-negative tissues were 42.9%and41.5%,respectively.The inter-observer agreement for determining n-Pit and n-Pap for normal mucosa were0.857 and 0.769,respectively,which is considered reliable.CONCLUSION:N-Pit and n-Pap,seen using EC,are considered useful predictors of normal mucosa and theabsence of H.pylori infection. | Hiroki Sato Haruhiro Inoue Haruo Ikeda Chiaki Sato Chainarong Phlanusittepha Bu'Hussain Hayee Esperanza Grace R Santi Yasutoshi Kobayashi Shin-ei Kudo | 2015 | World Journal of Gastroenterology2015，21，16： | 3 |
| 4 | Neck circumference positively related with central obesity, overweight, and metabolic syndrome in Chinese subjects with type 2 diabetes: Beijing Community Diabetes Study 4 显示文摘 | Yang G R Yuan S Y Fu H J Wan G Zhu L X Bu X L | 2010 | Diabetes Care2010，33，： | 1 |
| 5 | Leukotriene tM signaling through NF-kappa B-dependent BLT1 receptors on vascular smooth muscle ceils in atherosclerosis and intimal hyperplasia 显示文摘 | Bck M Bu DX Brnstrm R | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 6 | Thedirect release of nitric oxide by Gypenoside derived from theHerb Gynostemma pentaphyllum显示文摘 | Miles A Tanner Xin Bu J Alan Steimle P R Myers | 1999 | Biology and Chemis-try1999，3，5： | 1 |
| 7 | Using the LANDIS model to evaluate forest harvesting and planting strategies under possible warming climates in Northeaster显示文摘 | Bu R C He H S Hu Y M | 2008 | Forest Ecology and Management2008，254，： | 1 |
| 8 | Effects of particle size, organic matter and ionic strength on the phosphate sorption in different trophic lake sediments 显示文摘 | Wang S R Jin X C Bu Q Y | 2006 | Journal of Hazardous Materials2006，128，23： | 1 |
| 9 | Tracking differentiator design for the robust backstepping control of a flexible air-breathing hyperson- ic vehicle显示文摘 | BU X WU X ZHANG R | 2015 | Journal of the Franklin Institute2015，352，4： | 1 |
| 10 | The biological and clinical impact of inhibition of NF-KB-initiated apoptosis in dif-fuse large B cell lymphoma(DLBCL) 显示文摘 | Bavi P Uddin S Bu R | 2011 | J Pathol2011，224，3： | 1 |
| 11 | Structural diversity and modulation of coordination architectures with flexible dithioether or dis- ulfoxide ligands显示文摘 | LI J R BU X H | 2008 | Eur J Inorg Chem2008，39，14： | 1 |
| 12 | Improving nodal harvest in colorectal cancer:so what?显示文摘 | Porter GA Urquhart R Bu J | 2012 | Ann Surg Oncol2012，19，4： | 1 |
| 13 | Distraction osteogenesis for bony repair of cleft palate by using persistent elastic force: Experimental study in dogs显示文摘 | Liang L Liu C Bu R | 2005 | Cleft Palate Craniofac J2005，42，3： | 1 |
| 14 | Predicting the wetland distributions under climate warming in the Great Xing'an Mountains, northeastern China 显示文摘 | Liu H J Bu R C Liu J T | 2011 | Ecological Research2011，12，： | 1 |
| 15 | Cosegregation of C-insertion at position 961 with the A1555G mu-tation of the mitochondrial 12S rRNA gene in a large Chinese fam-ily with maternally inherited hearing loss显示文摘 | Li R Xing G Yan M Cao X Liu X-Z Bu X Guan M-X | | 0，，： | 1 |
| 16 | De t e r i o r a t i n g h e a 1 t h s t a t us in Stockholm 1998 -2002: r e s u 1 t s from repeated popu a t ionsur v e y s u s i n g t h e EQ - 5D 显示文摘 | Bu r s t r m K J o h a n n e s s o n M Re h n b e r g C | 2007 | Qua 1 L i f e Re s2007，16，9： | 1 |
| 17 | Idiopathicepiretinal membrane显示文摘 | BU SG KUIJER R LIXR HOOYMANS JM LOS U | 2014 | Retina2014，34，12： | 1 |
| 18 | Development of transformation system of rice based on binary bacterial artificial chromosome (BIBAC) vector显示文摘 | He R F Wang Y Y Bu B | 2006 | Actu Geneticu Sinica2006，33，3： | 1 |
| 19 | Y-shaped two-photon absorbing molecules with an imidazole thiazole core 显示文摘 | Feng K Mendonca C R Bu X R | 2004 | Chem Commun2004，10，： | 1 |
| 20 | Investigation for the operation of an integrated peristaltic micropump 显示文摘 | Husband B Bu M Evans A G R | 2004 | Journal of Micromechanics and Microengineering2004，14，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员