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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Peng's binding pancreaticojejunostomy after pancreaticoduodenectomy:a French prospective study显示文摘 | Buc E Flamein R Golfier C | 2010 | J Gastrointest Surg2010，14，： | 1 |
| 3 | KRAS mutations as an independent prognostic factor in pa- tients with advanced colorectal cancer treated with cetuximab 显示文摘 | Lievre A Bachet J B Boige V Cayre A Le Corre D Buc E | 2008 | J Clin Oncol2008，26，： | 1 |
| 4 | Peng' s binding pancreaticcojejunostomy 'after pancreaticcododenectomy: a French prospective study显示文摘 | Buc E Flamein R Golffier C | 2010 | J Gastrointest Surgy2010，14，4： | 1 |
| 5 | Peng’s binding pancreati-cojejunostomy after pancreaticoduodenectomy : a French prospec-tive study 显示文摘 | Buc E Flamein R Golffier C | 2010 | J Gastrointest Surg2010，14，4： | 1 |
| 6 | An improved synthesis of P-alanine 显示文摘 | Buc SR Ford JH Wise E | 1945 | Journal of the American Chemical Society1945，67，1： | 1 |
| 7 | Occurrence rotes of HLA-DRBI and HLA-DPBI alleles in patients suffering from vitiligo 显示文摘 | Buc M Fazekasova H Cechove E | 1998 | Eur J Dermatol1998，8，1： | 1 |
| 8 | Tobacco smoking:a factor of early onset of colorectal cancer显示文摘 | Buc E Kwiatkowski F AlvesA | 2006 | Dis Colon Rectum2006，49，12： | 1 |
| 9 | Occurrence rates of HLA-DRB1, HLA-DQB1, HLA-DPB1 alleles in patients suffering from vitiligo显示文摘 | Buc M Fazekasova H Cechova E | 1998 | Eur J Dermatol1998，8，1： | 1 |
| 10 | Occurrence rates of HLA-DRB1, HLA-DQB1, and HLA-DPB1 alleles in patients suffering from vitiligo显示文摘 | BUC M Fazekasova H Cechove E | 1998 | Fur J Dermatol1998，8，1： | 1 |
| 11 | Peng's binding pancreatico- jejunostomy after pancreaticoduodenectomy: a French prospec- tive study显示文摘 | Buc E Flamein R Golffier C | 2010 | J Gastrointest Surg2010，14，4： | 1 |
| 12 | Preoperative portal vein embolization with Amplatzer vascular plugs(AVP):A review of 17 cases显示文摘 | Kalenderian AC Chabrot P Buc E | 2011 | J Radiol2011，92，10： | 1 |
| 13 | Peng's binding pancreaticojejunostomy after pancreaticoduodenectomy:a French prospective study显示文摘 | Buc E Flamein R Golffier C | | 0，，04： | 1 |
| 14 | Peng's binding pancreatico- jejunostomy after pancreaticoduodenectomy: a French prospective study显示文摘 | Buc E Flamein R Golffier C | 2010 | J Gastrointest Surg2010，14，4： | 1 |
| 15 | Peng's binding pancreati- cojejunostomy after panereaticoduodenectomy: a french prospective study显示文摘 | Buc E Flamein R Golffier C | 2010 | J Gastrointest Surg2010，14，： | 1 |
| 16 | Massive hepatic necrosis with gastric, splenic, and pancreatic infarctions after ethanol ablation for hepatocellular carcinoma显示文摘 | Da Ines D Buc E Petitcolin V | 2010 | J Vase Interv Radiol2010，21，8： | 1 |
| 17 | Peng' s binding pancreaticojejunostomy after pancreaticoduodenectomy:a French prospective study显示文摘 | Buc E Flamein R Golffier C | 2010 | J Gastrointest Surg2010，14，4： | 1 |
| 18 | Peng's binding pancreaticojejunostomy after pancreaticoduodenectomy:a French prospective study显示文摘 | Buc E Flamein R Golffier C | 2010 | J GastrointestSurg2010，14，4： | 1 |
| 19 | Peng' s binding pancreatieoje- junostomy after pancreaticoduodeneetomy: a french prospective study 显示文摘 | Buc E Flamein R Golffier C | 2010 | J Gastrointest Surg2010，14，4： | 1 |
| 20 | Pengs binding pancreaticoje- junostomy after pancreaticoduodenectomy: a French prospective study 显示文摘 | Buc E Flamein R Golffier C | 2010 | J Gastrointest Surg2010，14，4： | 1 |
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