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| 1 | Presentation,management,and outcome of newly diagnosed glioblastoma in elderly patients显示文摘OBJECT: Optimum management for elderly patients with newly diagnosed glioblastoma(GBM) in the temozolomide(TMZ) era is not well defined.The object of this study was to clarify outcomes in this population.METHODS: The authors retrospectively reviewed 105 consecutive cases involving elderly patients(age ≥ 65 years) with newly diagnosed GBM who were treated at the Mayo Clinic between 2003 and 2008.RESULTS: The patients' median age was 74 years(range 66-87 years),and the median Karnofsky Performance Status(KPS) score was 80(range 40-90).Half of the patients underwent biopsy and half underwent resection.Patients with deep-seated lesions(19 patients [18%]) or multifocal lesions(34 patients [32%]) were more likely to have biopsy than resection(p = 0.0001 and 0.0009,respectively).New persistent neurological deficits developed in 7 patients(6.7%).Postoperative hemorrhage occurred in 6 patients(5.7%),all of whom underwent biopsy.Complete follow-up data regarding adjuvant treatment was available in 84 patients.Forty-one(49%) were treated with chemotherapy(mostly TMZ) and radiation therapy(RT),and 23(27%) with RT alone.Nineteen(23%) received only palliative care after surgery(more common with biopsy,p = 0.03).Chemotherapy complications occurred in 28.6%(Grade 3 or 4 hematological complications in 11.9%).The median values for progression-free survival(PFS) and overall survival(OS) were 3.5 and 5.5 months.In a multivariate analysis,younger age(p = 0.03,risk ratio [RR] 0.34,95% CI 0.13-0.89),single lesion(p = 0.02,RR 0.51,95% CI 0.30-0.89),resection(p = 0.04,RR 0.54,95% CI 0.31-0.94),and adjuvant treatment(p = 0.0001,RR 0.24,95% CI 0.11-0.49) were associated with better OS.Only adjuvant treatment was significantly associated with prolonged PFS(p = 0.0007,RR 0.27,95% CI 0.13-0.57).With combined therapy with resection,RT,and chemotherapy,the median PFS and OS were 8 and 12.5 months,respectively.CONCLUSIONS: The prognosis for GBM worsens with increasing age in elderly patients.With important risks,resection and adjuvant treatment are associated with prolonged survival.Although selection bias cannot be excluded in this retrospective study,advanced age alone should not necessarily preclude optimal resection followed by adjuvant radiochemotherapy. | Tanaka S Meyer FB Buckner JC Uhm JH Yan ES Parney IF | 2013 | 中国神经肿瘤杂志2013，11，1： | 4 |
| 2 | Treatment of nomal donors with recombinant growth factors for transplantation of allogeneic blood stem cells显示文摘 | Bensinger W Buckner CD Rowley S | 1996 | Bone Marrow Transplant1996，17，2： | 1 |
| 3 | Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators显示文摘 | Buckner S A Milicic I Daza A V | 2002 | Br J Pharmacol2002，135，3： | 1 |
| 4 | Knowledge- based interpretation of remote sensing images using semantic nets 显示文摘 | Tonjes R Growe S Buckner J Liedtke C E | 1999 | Photogrammetry Engineering and Remote Sensing1999，65，7： | 1 |
| 5 | Effects of left inferior prefrontal stimulation on episodic memory formation: a two - stage fMRI - rTMS study 显示文摘 | Kohler S Paus T Buckner RL | 2004 | J Cogn Neurosci2004，16，2： | 1 |
| 6 | Pharmacological and molecular analysis of ATP-sensitive K^+ channels in the pig and human detrusor显示文摘 | Buckner S Milicic I Daza A | 2000 | Eur J Pharmacol2000，400，： | 1 |
| 7 | Advances in Chagas disease drug de-velopment: 2009-2010 显示文摘 | Buckner F S Navabi N | 2010 | Curr Op Infect Dis2010，23，： | 1 |
| 8 | Spontaneous phasic contractions of the pig urinary bladder smooth mus- cle: characteristics and sensitivity to potassium channel modulators显示文摘 | Buckner S Milicic I Daza A etal | 2002 | Br J pharmacol2002，135，： | 1 |
| 9 | Treatment of normal donors with recombinant growth factor for trans- plantation of allogeneic blood stem ceils 显示文摘 | Bensinger WI Buckner CD Rowley S | 1996 | Bone Marrow Transplant1996，172，： | 1 |
| 10 | Synthesis of organi- cally-capped metallic zinc nanoparticles using electrical explosion of wires (EEW) coupled with PIERMEN显示文摘 | Abdelkader E M Jelliss P A Buckner S W | 2015 | Materials Chemistry and Physics2015，，149150： | 1 |
| 11 | CD4^+ FOXP3^+ T regulatory cells in hu- man autoimmunity : more than a numbers game 显示文摘 | LONG S A BUCKNER J H | 2011 | J Immunol2011，187，5： | 1 |
| 12 | Peripheral blood stem cell collection after paclitaxel,cyclophosphamide and recombinant human granulocyte colony-stimulating factor in patients with breast and ovarian cancer显示文摘 | Demirer T Rowley S Buckner C D | 1995 | J Clin Oncol1995，13，： | 1 |
| 13 | Lipids stimulate spore germination in the entomopathogenic ascomycete Ascosphaera aggregata显示文摘 | James R R Buckner J S | 2004 | Mycopathologia2004，158，2： | 1 |
| 14 | H∞ Control of Active Magnetic Bearings Using Artificial Neural Network Identification of Uncertainty显示文摘 | Nathan S Choi H Buckner D | 2003 | Systems Man & Cybernetics2003，11，2： | 1 |
| 15 | CD4 + Foxp3 + T regulatory cells in human autoimmunity: more than a numbers game显示文摘 | Long S A Buckner J I1 | 2011 | J lm- munol2011，187，5： | 1 |
| 16 | B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy 显示文摘 | Moir S Buckner CM Ho J | 2010 | Blood2010，116，25： | 1 |
| 17 | Controlling odors during grass composting 显示文摘 | Buckner S C Michel F C Jr | 2002 | BioCyele2002，43，9： | 1 |
| 18 | Cuticular Lipid Compo- sition of Hdiothis virescens and Helicoverpa zea Pupae显示文摘 | Buckner J S Maniaus M C Nelson D R | 1996 | Compara- tive Bio Phy Part B: Bio Mol Bio1996，114，2： | 1 |
| 19 | The yl gene of maize codes for phytoene synthase显示文摘 | BUCKNER B MIGUEL P S JANICK-BUCKNER D BENNETZEN J L | 1996 | Genetics1996，143，1： | 1 |
| 20 | Presentation, management, and outcome of elderly patients with newly-di- agnosed anaplastie astroeytoma 显示文摘 | Tanaka S Meyer FB Buckner JC | 2012 | J Neurooncol2012，110，2： | 1 |
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