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| 1 | Adiponectin,a key adipokine in obesity related liver diseases显示文摘Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis,non-alcoholic steatohepatitis (NASH),and progressive liver fibrosis is considered the most common liver disease in western countries.Fatty liver is more prevalent in overweight than normal-weight people and liver fat positively correlates with hepatic insulin resistance.Hepatic steatosis is regarded as a benign stage of NAFLD but may progress to NASH in a subgroup of patients.Besides liver biopsy no diagnostic tools to identify patients with NASH are available,and no effective treatment has been established.Visceral obesity is a main risk factor for NAFLD and inappropriate storage of triglycerides in adipocytes and higher concentrations of free fatty acids may add to increased hepatic lipid storage,insulin resistance,and progressive liver damage.Most of the adipose tissue-derived proteins are elevated in obesity and may contribute to systemic inflammation and liver damage.Adiponectin is highly abundant in human serum but its levels are reduced in obesity and are even lower in patients with hepatic steatosis or NASH.Adiponectin antagonizes excess lipid storage in the liver and protects from inflammation and fibrosis.This review aims to give a short survey on NAFLD and the hepatoprotective effects of adiponectin. | Christa Buechler Josef Wanninger Markus Neumeier | 2011 | World Journal of Gastroenterology2011，17，23： | 44 |
| 2 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 3 | Perioperative chemotherapy for advanced gastric cancer - results from a tertiary-care hospital in Germany显示文摘BACKGROUND Neoadjuvant/perioperative chemotherapy is the recommended treatment for advanced stages of gastric cancer(>T2,N+)before tumour resection in many European guidelines.However,there is no consensus as to whether perioperative chemotherapy is as effective in distal as in proximal tumours,in addition to a relevant uncertainty concerning appropriate treatment modalities for elderly patients.AIM To investigate the role of perioperative chemotherapy in advanced gastric cancer in patients from a German tertiary clinic with respect to efficacy,localisation,and age.METHODS We performed a retrospective analysis of 158 patients from our clinic with adenocarcinoma of the stomach or the gastroesophageal junction who underwent resection between 2008 and 2016.The data were evaluated particularly in relation to patient age,tumour site,and perioperative therapy.RESULTS Administration of perioperative chemotherapy did not lead to a significant survival advantage in our study population.The 5-year survival rates were 40%for patients who received perioperative chemotherapy and 29%for the group without perioperative chemotherapy(P=0.125).Our patients were on average distinctly older than patients in most of the published randomised controlled trials.Patients elder than 75 years received perioperative chemotherapy far less frequently.Patients with a proximal tumour received perioperative chemotherapy much more often.CONCLUSION This analysis reconfirms our previous data concerning the effectiveness of perioperative chemotherapy for advanced gastric cancer.There is reasonable doubt that the quality of the existing randomized controlled trials is sufficient to generally justify perioperative chemotherapy in patients with advanced gastric cancer independent of tumour localization or age. | Katrin Bauer Giulia Manzini Doris Henne-Bruns Peter Buechler | 2020 | World Journal of Gastrointestinal Oncology2020，12，5： | 4 |
| 4 | Adipose tissue fibrosis显示文摘The increasing prevalence of obesity causes a major interest in white adipose tissue biology.Adipose tissue cells are surrounded by extracellular matrix proteins whose composition and remodeling is of crucial importance for cell function.The expansion of adipose tissue in obesity is linked to an inappropriate supply with oxygen and hypoxia development.Subsequent activation of hypoxia inducible factor 1(HIF-1) inhibits preadipocyte differentiation and initiates adipose tissue fibrosis.Thereby adipose tissue growth is limited and excess triglycerides are stored in ectopic tissues.Stressed adipocytes andhypoxia contribute to immune cell immigration and activation which further aggravates adipose tissue fibrosis.There is substantial evidence that adipose tissue fibrosis is linked to metabolic dysfunction,both in rodent models and in the clinical setting.Peroxisome proliferator activated receptor gamma agonists and adiponectin both reduce adipose tissue fibrosis,inflammation and insulin resistance.Current knowledge suggests that antifibrotic drugs,increasing adipose tissue oxygen supply or HIF-1 antagonists will improve adipose tissue function and thereby ameliorate metabolic diseases. | Christa Buechler Sabrina Krautbauer Kristina Eisinger | 2015 | World Journal of Diabetes2015，6，4： | 3 |
| 5 | Regulation of scaven- ger receptor CD163 expression in human monocytes and macrophages by pro- and antiinfiammatory stimuli 显示文摘 | Buechler C Ritter M Orso E | 2000 | J Leukoc Biol2000，67，： | 1 |
| 6 | CTRP family : linking immunity to metabolism显示文摘 | Schffier A Buechler C | 2012 | Trends Endocrinol Metab2012，23，4： | 1 |
| 7 | Echo size and asymmetry:Impact on NEXRAD storm identification显示文摘 | Buechler D E S J Goodman | 1990 | Ap-plied Meteorology1990，29，9： | 1 |
| 8 | Clq/TNF-related protein-3 represents a novel and endogenous lipopolysaeehride antagonist of the adipose tissue 显示文摘 | Kopp A Bala M Buechler C | 2010 | Endocrinology2010，151，11： | 1 |
| 9 | Clq/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue显示文摘 | Kopp A Bala M Buechler C | 2010 | Endocrinology2010，151，11： | 1 |
| 10 | Simultaneous detection of seven dings of abuse by the triage panel for ding of abuse显示文摘 | Buechler K F Mol S Noar B | 1992 | Clin Chem1992，38，： | 1 |
| 11 | Regulation of scavenger receptor CD163 expression inhuman monocytes and macrophages by proand antiinflammatory stimuli显示文摘 | Buechler C Ritter M Orsó E | 2000 | J Leukoc Biol2000，67，1： | 1 |
| 12 | Intrathecal morphine and ketorolac analgesia after surgery:comparison of spontaneous and elicited responses in rats显示文摘 | Martin TJ Zhang Y Buechler N | 2005 | Pain2005，113，3： | 1 |
| 13 | Simultaneous detection of seven drugs of abuse by the triage panel for drug of abuse显示文摘 | Buechler K F | 1992 | Clin Chem1992，3，： | 1 |
| 14 | cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes显示文摘 | Taylor SS Buechler JA Yonemoto W | 1990 | Annu Rev Biochem1990，59，： | 1 |
| 15 | Regulation of scavenger recep?tor CD]63 expression itt human monocytes and macrophages by pro?and antiinflammatory stimuli 显示文摘 | Buechler C Ritter M Orso E | 2000 | J Leukoc BioI2000，67，： | 1 |
| 16 | CTRP family : linking immunity to metabolism 显示文摘 | Schaffler A Buechler C | 2012 | Trends Endocrinol Metab2012，23，4： | 1 |
| 17 | Regulation of scavenger receptor CD 163 in human monocyte and macrophages by pro-and antiimflammatory stimuli显示文摘 | Buechler C Ritter M Orso E | 2000 | J Leukoc Biol2000，67，1： | 1 |
| 18 | Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer 显示文摘 | Buechler S | 2009 | BMC Cancer2009，9，： | 1 |
| 19 | Effects of the new Clq/TNF-related protein (CTRP-3) 'cartonectin' on the adipocytic secretion of adipokines显示文摘 | Wolfing B Buechler C Weigert J | 2008 | Obesity ( Sil- verSpring)2008，16，7： | 1 |
| 20 | Lightning activity within a Tornadic thunderstorm observed by the optical transient detector(OTD)显示文摘 | Buechler D E K T Driscoll S J Goodman | 2000 | J Geophys Res2000，27，15： | 1 |
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