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| 1 | Nuclear β-catenin expression as a prognostic factor in advanced colorectal carcinoma显示文摘AIM: To investigate the changing pattern of β-catenin expression and its prognostic value in advanced colorectal cancer (CRC). METHODS: Archival tumor samples were analyzed for β-catenin using immunohistochemistry (IHC) in 95 patients with advanced CRC. RESULTS: Membranous β-catenin expression was found in the normal colorectal epithelium. Almost 100% of CRC cases showed membranous and cytoplasmic expression,and 55 (58%) cases showed nuclear expression. In univariate (Kaplan-Meier) survival analysis,only the nuclear index (NI) was a signifi cant predictor of disease-free survival (DFS) (P = 0.023; n = 35),with a NI above the median associated with longer DFS (34.2 mo) than those with a NI below the median (15.5 mo) (P = 0.045,ANOVA). The other indices were not significant predictors of DFS,and none of the three tested indices (for membranous,cytoplasmic,or nuclear expression) predicted disease-specific survival (DSS). However,when dichotomized as positive or negative nuclear expression,the former was a signifi cant predictor of more favorable DFS (P = 0.041) and DSS (P = 0.046). CONCLUSION: Nuclear β-catenin expression provides additional information in predicting patient outcome in advanced CRC. | Adam Elzagheid Abdelbaset Buhmeida Eija Korkeila Yrj Collan Kari Syrjnen Seppo Pyrhnen | 2008 | World Journal of Gastroenterology2008，14，24： | 13 |
| 2 | Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma显示文摘AIM:To correlate cyclooxygenase-2(COX-2)expression profile with clinical and pathological variables to assess their prognostic/predictive value in colorectal carcinoma(CRC).METHODS:Archival tumor samples were analyzed using immunohistochemistry for COX-2 expression in 94 patients with CRC.Patients were diagnosed and treatedat the Departments of Surgery and Oncology,King Abdulaziz University Hospital,Saudi Arabia.RESULTS:Fifty-six percent of the tumors showed positive cytoplasmic COX-2 expression,whereas 44%of cases were completely COX-2-negative.There were no significant correlations between COX-2 expression and sex,age,grade or tumor location.However,COX-2 expression revealed a significant correlation with tumor stage(P=0.01)and distant metastasis(P=0.02),and a borderline association with lymph node involvement(P =0.07).Tumors with high COX-2 expression showed a higher recurrence rate than tumors with no expression(P<0.009).In univariate Kaplan-Meier survival analysis,there was a significant(P=0.026)difference in disease-free survival between COX-2-positive and negative tumors in favor of the latter.COX-2 expression did not significantly predict disease-specific survival,which was much shorter for COX-2-positive tumors.In multivariate(COX)models,COX-2 did not appear among the independent predictors of disease-free survival or disease-specific survival.CONCLUSION:COX-2 expression seems to provide useful prognostic information in CRC,while predicting the patients at high risk for recurrent disease. | Jaudah Al-Maghrabi Abdelbaset Buhmeida Eman Emam Kari Syrjnen Abdulrahman Sibiany Mohmmad Al-Qahtani Mahmoud Al-Ahwal | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Loss of MUC2 expression predicts disease recurrence and poor outcome in colorectal carcinoma显示文摘 | Adam Elzagheid Fatma Emaetig Abdelbaset Buhmeida Matti Laato Omran El-Faitori Kari Syrj?nen Yrj? Collan Seppo Pyrh?nen | 2013 | Tumor Biology2013，，2： | 2 |
| 4 | Prognostic signifi- cance of matrix metalloproteinase-9 ( MMP-9 ) in stage II colorectal carcinoma 显示文摘 | Buhmeida A Bendardaf R Hilska M | 2009 | J Gastrointest Cancer2009，40，34： | 1 |
| 5 | PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage Ⅱ colorectal carcinoma显示文摘 | Buhmeida A Bendardaf R Hilska M | 2009 | Ann Oncol2009，20，7： | 1 |
| 6 | VEGF-1 expression in colorectal cancer is associated with disease localization, stage, and long-term disease-specific survival 显示文摘 | Bendardaf R Buhmeida A Hilska M | 2008 | Anticancer Res2008，28，6： | 1 |
| 7 | Up-regulation of α-catenin is associated with increased lymph node involvement in colorectal cancer显示文摘AIM: To investigate the changing pattern of α-catenin expression and its relationship to clinical and pathological features of colorectal cancer (CRC) patients. METHODS: Archival tumor samples were analyzed using immunohistochemistry (IHC) for α-catenin in 91 patients with advanced CRC. RESULTS: The values of α-catenin membrane index (MI) and cytoplasmic index (CI) were significantly related to the depth of tumor invasion (P = 0.027, P = 0.020, respectively), high indices being associated with increased depth of the primary tumor invasion (T3 and T4). Similarly, patients with high α-catenin expression had a signifi cantly increased risk of lymph node metastasis (32/39 vs 37/52 for MI and 37/45 vs 32/46 for CI) (P = 0.001, P = 0.0001, respectively, for LNN status). An altered expression (i.e., cytoplasmic pattern) was also related (P = 0.047) to the response to chemotherapy; patients with low CI were more responsive (CR: 7/46) than patients with high CI values (CR: 0/45). There was a marginal effect on survival in patients time with metastases (SWM) (P = 0.087); patients with low CI showing slightly longerSWM, but no such effect on disease free survival (DFS) or disease specifi c survival (DSS). As to co-expression with another member of the adhesion complex (β-catenin), high α-catenin/β-catenin MI index was of marginal signifi cance in predicting longer DSS (P = 0.063, log-rank). CONCLUSION: The results implicate that high α-catenin expression is intimately involved in the key regulatory mechanisms leading to invasive phenotype, lymph node metastases, and progressive disease in CRC. | Adam Elzagheid Abdelbaset Buhmeida Eija Korkeila Yrj Collan Kari Syrjnen Seppo Pyrhnen | 2008 | World Journal of Gastroenterology2008，14，31： | 1 |
| 8 | Evaluation of HER-2/neu gene amplification by fluorescence in situ hybridization andimmunohistochemistry in saudi female breast cancer显示文摘 | Heba AL-Khattabi Abdelhakeem Kelany Abdelbaset Buhmeida et al | 2010 | Anticancer Research2010，30，10： | 1 |
| 9 | Nucleolar morphometry in fine needle aspiration biopsies of the prostate显示文摘 | Buhmeida A Kujari H Collan Y | 2001 | Anal Quant Cytol Histol2001，23，3： | 1 |
| 10 | MMP-9 (gelatinase B) expression is associated with disease-free survival and disease-specific survival in colorectal cancer patients显示文摘 | Bendardaf R Buhmeida A Hilska M | 2010 | Cancer Invest2010，28，1： | 1 |
| 11 | PL4,2 (group Ⅱ A phospholipase A2 ) as a prognostic determinant in stage Ⅱ colorectal carcinoma 显示文摘 | Buhmeida A Bendardaf R Hilska M | 2009 | Ann Oncol2009，20，7： | 1 |
| 12 | Prognostic value of proliferation markers:immunohistochemical Ki-67 ex- pression and cytometric S-phase fraction of women with breast cancer in Libya显示文摘 | Ermiah E Buhmeida A Abdalla F et a/ | 2012 | J Cancer2012，3，： | 1 |
| 13 | Prognostic significance of DNA image cytometry in Libyan breast cancer显示文摘 | Errniah E Abdalla F Buhmeida A | 2012 | Oncology2012，83，3： | 1 |
| 14 | M M P-9(gela-tinase B)expression is associated with disease-free sur-vival and disease-specific survival in colorectal cancer pa-tients显示文摘 | Bendardaf R Buhmeida A Hilska M | | 0，，1： | 1 |
| 15 | Diagnosis delay in Libyan female breast cancer显示文摘 | Ermiah E Abdalla F Buhmeida A | 2012 | BMC Res Notes2012，16，5： | 1 |
| 16 | Prognos- tic value of proliferation markers: immunohistochemical ki-67 expression and cytometric s-phase fraction of women with breast cancer in libya 显示文摘 | ERMIAH E BUHMEIDA A ABDALLA F | 2012 | J Cancer2012，3，： | 1 |
| 17 | Expression of cell cycle regulators p21 and p27 as predictors of disease outcome in colorectal carcinoma显示文摘 | A1-Maghrabi J AI-Ahwal M Buhmeida A | 2012 | J Gastrointest Cancer2012，43，2： | 1 |
| 18 | Diagnosis delay in Libyan female breast cancer显示文摘 | Ermiah E Abdalla F Buhmeida A | 2012 | BMC Res Notes2012，5，： | 1 |
| 19 | MMP-9(gelatinase B) expression is associated with disease-free survival and disease-specific survival in colorectal cancer patients显示文摘 | Bendardaf R Buhmeida A Hilska M | 2010 | Cancer Invest2010，28，1： | 1 |
| 20 | Prognosticsignificance of matrix metalloproteinase-9(MMP-9)instageⅡcolorectal carcinoma显示文摘 | Buhmeida A Bendardaf R Hilska M | 2009 | J Gastrointest Cancer2009，40，34： | 1 |
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