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| 1 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 2 | Mechanism involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia显示文摘 | Buisson A Margaill L Callehert J | 1993 | J Neurochem1993，61，2： | 1 |
| 3 | Coupling of hydraulic hysteresis and stress-strain behaviour in unsaturated soils 显示文摘 | Wheeler S J Sharma R S Buisson M S R | 2003 | Geotechnique2003，53，1： | 1 |
| 4 | Detection of Cryptosporidium parvum DNA in formed human feces by a sensitive PCR-based assay including uracil-N-glycosylase inactivation 显示文摘 | Gobet P Buisson J C Vagner O | 1997 | J Clin Microbiol1997，35，1： | 1 |
| 5 | Coupling of hydraulic hysteresis and stress-strain behaviour in unsaturated soils显示文摘 | Wheeler S J Sharma R S Buisson M S R | 2003 | Geotechnique2003，53，1： | 1 |
| 6 | Bacillus cereus produces several nonproteinaceous insecticidal exotoxins 显示文摘 | Perchat S Buisson C Chaufaux J | 2005 | Journal of Invertebrate Pathology2005，90，2： | 1 |
| 7 | Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia显示文摘 | Buisson A Margaill I Callebert J | 1993 | J Neurochem1993，61，2： | 1 |
| 8 | Carbonisation of Fir (Abies bornmulleriana) wood in an open pyrolysis system at 50- 300 ℃显示文摘 | M DUBOIS A NAJI J P BUISSON | 2003 | J Anal Appl Pyrol2003，67，： | 1 |
| 9 | 显示文摘 | Dubois M Naji A Buisson J P ct al | 2000 | Carbon2000，38，9： | 1 |
| 10 | Coupling of hydraulic hysteresis and stress-strain behaviour in unsaturated soils 显示文摘 | Wheeler S J Sharma R S Buisson M S R | 2003 | Geotechnique2003，53，1： | 1 |
| 11 | A generic design methodology for sliding mode control of switched systems显示文摘 | Richard P Y Cormerais H Buisson J | 2006 | Nonlinear Analysis2006，65，9： | 1 |
| 12 | Storage of New Zealand Jack mackerel (Trachurus novaezelandiae) in ice: chemical, microbiological and sensory assessment显示文摘 | RYDER J M BUISSON D H SCOTT D N | 1984 | Journal of Food Science1984，49，14： | 1 |
| 13 | Coupling of hydraulic hysteresis and stress-strain behavior in unsaturated soil显示文摘 | WHEELER S J SHARMA R S BUISSON M S R | 2003 | Geotechnique2003，53，1： | 1 |
| 14 | Coupling of hydraulic hysteresis and stress-strain behaviour in unsaturated soils显示文摘 | WHEELER S J SHARMA R S BUISSON M S R | 2003 | Geoteehnique2003，53，1： | 1 |
| 15 | Coupling of hydraulic hysteresis and stress-strain behaviour in unsaturated soils显示文摘 | WHEELER S J SHARMA R S BUISSON M S R | 2003 | Geotechnique2003，53，1： | 1 |
| 16 | Patenting strategy of entrepreneurial orientated firms in New Zealand显示文摘 | Darroch J Miles M P Buisson T | | 0，，01： | 1 |
| 17 | Incidence, riskfactors,and outcome of severe sepsis and septic shock in adults: amulticenter prospective study in intensive care units 显示文摘 | Brun - Buisson C Doyon F Carlet J | 1995 | JAMA1995，274，12： | 1 |
| 18 | Eva1uation of new diagnostic technologies:bronchoalveolar lavage and the diagnosis of ventilator-associated pneumonia显示文摘 | Brun Buisson C Guyatt G H | 1994 | Crit Care Med1994，22，： | 1 |
| 19 | Couplingof hydraulic hysteresis and stress-strain behaviour inunsaturated soils显示文摘 | WHEELER S J SHARMA R S BUISSON M S R | 2003 | Géotechnique2003，53，： | 1 |
| 20 | Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia显示文摘 | Margai L Calleber J | 1993 | J Neurochem1993，6，： | 1 |
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