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| 1 | Etiology and long-term outcome of extrahepatic portal vein obstruction in children显示文摘AIM:To study the management and outcome of children with extrahepatic portal vein obstruction(EHPVO) in a whole country population.METHODS:A nationwide multicenter retrospective case series of children with EHPVO was conducted.Data on demographics,radiographic studies,laboratory workup,endoscopic and surgical procedures,growth and development,were extracted from the patients' charts.Characteristics of clinical presentation,etiology of EHPVO,management and outcome were analyzed.RESULTS:Thirty patients,13 males and 17 females,19(63.3%) Israeli and 11(36.7%) Palestinians,were included in the analysis.Age at presentation was 4.8± 4.6 years,and mean follow-up was 4.9±4.3 years.Associated anomalies were found in 4 patients.The incidence of EHPVO in Israeli children aged 0-14 years was 0.72/million.Risk factors for EHPVO were detected in 13(43.3%)patients,including 9 patients(30%) with perinatal risk factors,and 4 patients(13.3%) with prothrombotic states:two had low levels of protein S and C,one had lupus anticoagulant,and one was homozygous for methyltetrahydrofolate reductase mutations.In 56.6% of patients,no predisposing factors were found.The most common presenting symptoms were an incidental finding of splenomegaly(43.3%),and upper gastrointestinal bleeding(40%).No differences were found between Israeli and Palestinian children with regard to age at presentation,etiology and clinical symptoms.Bleeding occurred in 18 patients(60%),at a median age of 3 years.Sclerotherapy or esophageal banding was performed in 20 patients.No sclerotherapy complications were reported.Portosystemic shunts were performed in 11 patients(36.6%),at a median age of 11(range 3-17)years:splenorenal in 9,mesocaval in 1,and a meso-Rex shunt in 1 patient.One patient underwent splenectomy due to severe pancytopenia.Patients were followed up for a median of 3(range 0.5-15)years.One patient died aged 3 years due to mucopolysaccharidase deficiency type Ⅲ.None of the patients died due to gastrointestinal bleeding.CONCLUSION:EHPVO is a rare disorder.The etiological factors are still mostly unknown,and the endoscopic and surgical treatment options ensure a good long-term prognosis. | Batia Weiss Eyal Shteyer Asaf Vivante Drora Berkowitz Shimon Reif Zvi Weizman Yoram Bujanover Rivka Shapiro | 2010 | World Journal of Gastroenterology2010，16，39： | 6 |
| 2 | NOD2/CARD15 mutation analysis and genotype-phenotype correlation in Jewish pediatric patients compared with adults with Crohn’s disease显示文摘 | Batia Weiss Raanan Shamir Yoram Bujanover Mati Waterman Corina Hartman Akiva Fradkin Drora Berkowitz Ilana Weintraub Ram Eliakim Amir Karban | 2004 | The Journal of Pediatrics2004，，2： | 2 |
| 3 | Increasing the value ofa biorefinery based on hot-water extraction: Lignin products 显示文摘 | Bujanovic B Goundlkar M J Amidon T E | 2012 | TAPPI2012，11，1： | 1 |
| 4 | Demyelinative encepha- litis responsive to intravemous immunoglobulin therapy显示文摘 | Assa A Watemberg N Bujanover Y | 1999 | Pediaterce1999，104，： | 1 |
| 5 | Increasing the value of a biorefinery based on hot-water extraction : Lignin products显示文摘 | BUJANOVIC B M GOUNDALKAR M J AMIDON T E | 2012 | Tappi Journal2012，11，1： | 1 |
| 6 | Hydrogen absorption and electrochemical properties of Mg-Ni-type alloys synthesized by mechanical alloying 显示文摘 | SIMICIC M V ZDUnC M DIMITRIJEVIC R NIKOLIC?BUJANOVIC L POPOVIC N H | 2006 | Journal of Power Sources2006，158，： | 1 |
| 7 | Demyelinative brainstem encephalitis responsive to intravenous immunoglobulin therapy显示文摘 | Assa A Watemberg N Bujanover Y | 1999 | Pediatrics1999，104，21： | 1 |
| 8 | Demyelinative brainstem encephalitis responsive to intravenous immunoglobulin therapy 显示文摘 | Assa A Watemberg N Bujanover Y | 1999 | Pediatrics1999，104，： | 1 |
| 9 | Demyelinative brainstem encephalitis responsive to intravenous immunoglobulin therapy显示文摘 | Assa A Watemberg N Bujanover Y | 1999 | Pediatrics1999，104，2： | 1 |
| 10 | Liver enzyme abnormalities in gram-negative baeteremia of premature infants显示文摘 | Shamir R Maayan-Metzger A Bujanover Y | 2000 | Pediatr Infect Dis J2000，19，6： | 1 |
| 11 | Demyelinative brainstem encephalitis responsive to intravenous immunoglobulin therapy显示文摘 | Assa A Watemborg N Bujanover Y | 1999 | Pediatrics1999，104，2： | 1 |
| 12 | De- myelinative brainstem en - cephalitis respon- sive to intravenous immanoglobulin therapy 显示文摘 | Assa A Watemberg N Bujanover Y | 1999 | Pediatrics1999，104，2： | 1 |
| 13 | NOD2/CARD15 mutation analysis and genotype-phenotype correlation in Jewish pediatric compared with adults with Crohn's disease 显示文摘 | Weiss B Shamir R Bujanover Y Waterman M Hartman C Fradkin A | 2004 | J Pediatr2004，145，2： | 1 |
| 14 | Liver enzyme abnormalities in gram-negative bacteremia of premature infants 显示文摘 | Shamir R Maayan-Metzger A Bujanover Y | 2000 | Pediatr Infect Dis J2000，19，6： | 1 |
| 15 | Nodular gastritis and Helicobacter pylori 显示文摘 | Bujanover Y Konikoff F Baratz M | 1990 | Pediatr Gastroenterol Nutr1990，11，1： | 1 |
| 16 | Liver enzyme abnormalities in gram-negative bacteremia of premature infants显示文摘 | Shamir R Maayan-Metzger A Bujanover Y | 2000 | Pediatr Infect Dis J2000，19，6： | 1 |
| 17 | Liver enzyme abnormalities in gram-negative bacteremia of premature infants显示文摘 | Shamir R Maayan-Metzger A Bujanover Y | 2000 | Pediatr Infect Dis J2000，19，6： | 1 |
| 18 | Laparoscopic cholecystectomy: Treatment of choice for cholelithiasis in children显示文摘 | Itzhak Vinograd M.D. Ariel Halevy M.D. Baruch Klin M.D. Michael Negri M.D. Yoram Bujanover M.D | 1993 | World Journal of Surgery1993，，2： | 1 |
| 19 | Liver enzymeabnormalities in gram-negative bacteremia of premature infants显示文摘 | Shamir R Maayan-Metzger A Bujanover Y | 2000 | Pediatr Infect Dis J2000，19，6： | 1 |
| 20 | Methotrexate Treatment in Pediatric Crohn Disease Patients Intolerant or Resistant to Purine Analogues显示文摘 | B Weiss A Lerner R Shapiro E Broide A Levine A Fradkin Y Bujanover | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，5： | 1 |
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