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| 1 | Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents显示文摘AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF treatment.METHODS:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected retrospectively.They failed to show response or were intolerant to conventional treatments,including steroids or immunomodulators.Screening measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were identified.RESULTS:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used adalimumab.Before anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of patients.Thirty patients(8%)had LTBI.Sixteen cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF treatment.LTBI(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk factors.CONCLUSION:Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD.The considerable burden of TB and marked immunosuppression might be attributed to this risk. | Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong Kook Lee Dong Wook Lee Sung Kook Kim Tae Oh Kim Jonghun Lee Hyung Wook Kim Sam Ryong Jee Seun Ja Park Hyun Jin Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 5 |
| 2 | Dissociation in effects of lesions of the nucleus accumbens core and shell on appetitive Pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by D-amphetamine显示文摘 | Parkinson JA Olmstead MC Bums LH Robbins TW Everitt BJ | 1999 | J Neurosci1999，19，7： | 1 |
| 3 | Intravenous gamma-globulin treatment and retreatment in Kawasaki disease: US/ Canadian Kawasaki Syndrome Study Group 显示文摘 | Bums JC Capparelli EV Brown JA | 1998 | Pediatr Infect Dis J1998，17，12： | 1 |
| 4 | Mouse models of Alzheimer's disease: a quest for plaques andtangles显示文摘 | Richardson JA Bums DK | 2002 | ILAR J2002，43，： | 1 |
| 5 | Office-based 532-nm pulsed KTP laser treatment of glottal papillomatosis and dysplasia显示文摘 | Zeitels SM Akst LM Bums JA | 2006 | Ann Otol Rhinol Laryngol2006，115，9： | 1 |
| 6 | White matter lesions are prevalent but differentially related with cognition in aging and ear- ly Alzheimer disease显示文摘 | Bums JM Church JA Johnson DK | 2005 | Arch Neurol2005，62，12： | 1 |
| 7 | Multiple shoot production from seedling explants of slash pine (Pinus elliottii Engelm) 显示文摘 | Bums JA Schwarz O J Sch Larboum SE | 1991 | Plant Cell Reports1991，10，9： | 1 |
| 8 | The Influ- ence of the Left Ventricular Geometry on the Left Atrial Size and Left Ventricular Filling Pressure in Hypertensive Patients, as Assessed by Echocardiography 显示文摘 | In Jeong Cho Wook Bum Pyun Gil Ja Shin | 2009 | Korean Circ J2009，39，4： | 1 |
| 9 | Long-term botulinum toxin treat- ment of benign essential blepharospasm, hemifacial spasm, and Meige syndrome 显示文摘 | Czyz CN Bums JA Petrie TP | 2013 | Am J Ophthalmol2013，156，1： | 1 |
| 10 | Transnasal endoscopic repair of cranionasal fistulae: a refined technique with long-term follow-up显示文摘 | Bums JA Dodson EE Gross CW | 1996 | Laryngoscope1996，106，： | 1 |
| 11 | Technique of en block laser endoscopic frontolateral laryngectomy for glotic cancer显示文摘 | Zeitels SM Dailey SH Bums JA | 2004 | Laryngoscope2004，114，： | 1 |
| 12 | The effect of surfactant on eustachian tube function in a gerbil model of otitis media with effusion显示文摘 | Fomadley JA Bums JK | 1994 | Otolaryn- gol Head Neck Surg1994，110，1： | 1 |
| 13 | Custom-made foot orthoses for the treatment of foot pain显示文摘 | Hawke F Bums J Radford JA | | 0，，： | 1 |
| 14 | White matter lesions are prev- alent but differentially related with cognition in aging and early A1- zheimer disease 显示文摘 | Bums JM Church JA Johnson DK | 2005 | Arch Neurol2005，62，12： | 1 |
| 15 | Staff nurses and students:the good, the bad, and the ugly显示文摘 | Koontz AM Mallory JL Bums JA | 2010 | Med Surg Nurs2010，19，4： | 1 |
| 16 | Modified Kinusian dacryocystorhiostomy: A re- view of 122 cases显示文摘 | Bums JA Cahill KV | 1995 | Ophthalmic Surg1995，16，11： | 1 |
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