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| 1 | 7,8-dihydroxyflavone,a small molecular TrkB agonist,is useful for treating various BDNF-implicated human disorders显示文摘Brain-derived neurotrophic factor(BDNF)regulates a variety of biological processes predominantly via binding to the transmembrane receptor tyrosine kinase TrkB.It is a potential therapeutic target in numerous neurological,mental and metabolic disorders.However,the lack of efficient means to deliver BDNF into the body imposes an insurmountable hurdle to its clinical application.To address this challenge,we initiated a cell-based drug screening to search for small molecules that act as the TrkB agonist.7,8-Dihydroxyflavone(7,8-DHF)is our first reported small molecular TrkB agonist,which has now been extensively validated in various biochemical and cellular systems.Though binding to the extracellular domain of TrkB,7,8-DHF triggers TrkB dimerization to induce the downstream signaling.Notably,7,8-DHF is orally bioactive that can penetrate the brain blood barrier(BBB)to exert its neurotrophic activities in the central nervous system.Numerous reports suggest 7,8-DHF processes promising therapeutic efficacy in various animal disease models that are related to deficient BDNF signaling.In this review,we summarize our current knowledge on the binding activity and specificity,structure-activity relationship,pharmacokinetic and metabolism,and the pre-clinical efficacy of 7,8-DHF against some human diseases. | Chaoyang Liu Chi Bun Chan Keqiang Ye | 2016 | Translational Neurodegeneration2016，5，1： | 7 |
| 2 | An antifungal peptide from Phaseolus vulgaris cv. brown kidney bean显示文摘A 5.4-kDa 抗真菌的肽与对对 Mycosphaerella arachidicola (IC50= 3 M ) 的 defensins 和禁止的活动高度相应的一个 N 终端序列, Setospaeria turcica 和 Bipolaris maydis,从 Phaseolus vulgaris cv 的种子被孤立。棕色的菜豆。肽被采用必要的一个协议净化 Affi 胶化蓝胶化和单音的 S 上并且最后的吸附 Superdex 75 上的胶化过滤。对 M 的肽的抗真菌的活动。arachidicola 在 pH 范围是稳定的 312 并且在温度范围 0 桴 ?? 整浲湩污搠浯楡獮漠 ? | Yau Sang Chan Jack Ho Wong Evandro Fei Fang Wen Liang Pan Tzi Bun Ng | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 6 |
| 3 | Risk Factors and Prognosis of Pulmonary Complications After Endoscopic Submucosal Dissection for Gastric Neoplasia显示文摘 | Chan Hyuk Park Hyunzu Kim Young Ae Kang In Rae Cho Bun Kim Su Jin Heo Suji Shin Hyuk Lee Jun Chul Park Sung Kwan Shin Yong Chan Lee Sang Kil Lee | 2013 | Digestive Diseases and Sciences2013，，2： | 2 |
| 4 | Randomized Trial of Endoscopic Sphincterotomy With Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Removal of Bile Duct Stones显示文摘 | Anthony Yuen Bun Teoh Frances Ka Yin Cheung Bing Hu Ya Min Pan Larry Hin Lai Philip Wai Yan Chiu Simon Kin Hung Wong Francis Ka Leung Chan James Yun Wong Lau | 2013 | Gastroenterology2013，，： | 2 |
| 5 | Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia显示文摘 | Wen Liang Pan Jack Ho Wong Evandro Fei Fang Yau Sang Chan Tzi Bun Ng Randy Chi Fai Cheung | 2014 | Biochemical Pharmacology2014，，： | 1 |
| 6 | Fiber property modification by mechanical pretreatment显示文摘 | Yung Bun Seo Chan Ho Choi and Seung Won Seo | 2002 | Tappi J2002，1，1： | 1 |
| 7 | Randomized Trial of Endoscopic Sphincterotomy With Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Removal of Bile Duct Stones显示文摘 | Anthony Yuen Bun Teoh Frances Ka Yin Cheung Bing Hu Ya Min Pan Larry Hin Lai Philip Wai Yan Chiu Simon Kin Hung Wong Francis Ka Leung Chan James Yun Wong Lau | 2013 | Gastroenterology2013，，： | 1 |
| 8 | Fiber property modification by mechanical pretreatment 显示文摘 | Yung Bun Seo Chan Ho Choi Seung Won Seo | 2002 | TAPPI Jouranl2002，1，1： | 1 |
| 9 | T ‐ S pot. TB outperforms tuberculin skin test in predicting development of active tuberculosis among household contacts显示文摘 | Chi Chiu Leung Wing Cheong Yam Pak Leung Ho Wing Wai Yew Chi Kuen Chan Wing Sze Law Shuk Nor Lee Kwok Chiu Chang Lai Bun Tai Cheuk Ming Tam | 2015 | Respirology2015，，3： | 1 |
| 10 | Expression of C-terminal truncated and full-length Babesia bigemina rhoptry-associated protein 1 and their potential use in enzyme-linked immunosorbent assay显示文摘 | Suthisak Boonchit Andy Alhassan Bun Chan Xuenan Xuan Naoaki Yokoyama Mamoru Ooshiro Will L. Goff Suryakant D. Waghela Gale Wagner Ikuo Igarashi | 2006 | Veterinary Parasitology2006，，1： | 1 |
| 11 | Strange particle production in nuclear collisions at 200 GeV per nucleon显示文摘 | T. Alber H. Appelsh?user J. B?chler J. Bartke H. Bia?kowska M. A. Bloomer R. Bock W. J. Braithwaite D. Brinkmann R. Brockmann P. Bun?i? P. Chan S. I. Chase J. G. Cramer P. B. Cramer I. Derado V. Eckardt J. Eschke C. Favuzzi D. Ferenc B. Fleischmann P. Fok | 1994 | Zeitschrift für Physik C Particles and Fields1994，，2： | 1 |
| 12 | Suicidal ideation and suicidal attempts in a population - based study of Chinese people:Risk attributable to hopelessness, depression and social factors 显示文摘 | Yin Bun Cheung C K Law Brandford Chan | 2006 | Affect Disorders2006，90，： | 1 |
| 13 | Suicidal ideation and suicidal attempts in a population-based study of Chinese people:Risk attributable to hopelessness,depression,and social factors显示文摘 | Yin Bun Cheung CK Law Brandford Chan | 2006 | Affective Disord2006，90，： | 1 |
| 14 | Suicidal ideation and suiei--dal attempts in a population--based study of Chinese people: Risk attributable to hopelessness, depression, and social factors显示文摘 | Yin Bun Cheung Law C K Brandford Chan | 2006 | AffectiveDisord2006，90，： | 1 |
| 15 | Direct incision versus submucosal tunneling as a method of creating transgastric accesses for natural orifice transluminal endoscopic surgery ( NOTES ) peritoneoscopy: Randomized controlled trial显示文摘 | Anthony Yuen Bun Teoh Philip Wai Yan Chiu Shannon Melissa Chan Tiffany Cho Lam Wong James Yun Wong Lau Enders Kwok Wai Ng | 2012 | Digestive Endoscopy2012，，3： | 1 |
| 16 | Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells显示文摘 | Dong Joon Kim Young Soo Park Min Gu Kang Yeon-Mi You Yuri Jung Han Koo Jung-Ae Kim Mi-Ju Kim Seung-Mo Hong Kyong Bun Lee Ja-June Jang Kyung Chan Park Young Il Yeom | 2015 | Experimental Cell Research2015，，1： | 1 |
| 17 | Seroprevalence of Brucellosis Disease and Lumpy Skin Disease on Cattles at Svay Rieng and Prey Veng Province, Cambodia显示文摘LSD (Lumpy Skin Disease) is a poxviral disease with significant morbidity in cattle and belongs to the family Poxviridae and the genus Capripoxvirus and is transmitted by hematophagous arthropod vectors. Despite the typically low mortality rate, economic costs arise from deterioration in health, decreased milk production, miscarriages, infertility and harmed hides. Brucellosis disease is one of the most common contagious and communicable zoonotic diseases with high rates of morbidity and lifetime sterility. Serological tests with ELISA (Enzyme-Linked Immunosorbent Assays) indicate exposure to Brucella and LSD in cattle. To identify the presence of those diseases, the research was conducted in two provinces, Svay Rieng and Prey Veng, in Cambodia, starting from July 2021 to January 2022. In the study, the 2018 Thusfield method was adopted, and two cattle were selected from 216 households in the two provinces (112 in Svay Rieng and 104 in Prey Veng). However, not all the families had two cattle, so the total sample size was 300 cattle (227 in Svay Rieng and 73 in Prey Veng). As a result, there was only one brucellosis disease case in Svay Rieng Province, while that disease was not found at all in Prey Veng. Meanwhile, LSD was higher in Prey Veng (80% of the tested cattle) than in Svay Rieng (69%). Among all of the tested cattle, 66.7% had the highest BS (Body Score = 4). The finding suggests that LSD was prevalent in the studied areas, which may cause economic losses. Thus, preventive measures should be taken properly to tackle this issue. Although Brucellosis was a rare case in the studied areas, it may spread faster, causing abortion in cattle and women. Biosecurity is needed to ensure a strict control over this disease. | Khoeun Sokun Kong Saroeun Bun Chan Ren Theary Ith Manay Chan Bunyeth Lay Hort Hin Lyhour Theng Kouch | 2023 | Journal of Environmental Science and Engineering(B)2023，12，4： | 0 |
| 18 | 卡马西平与库欣综合征的假阳性地塞米松抑制试验显示文摘 | Ronald C W Ma Wing Bun Chan Wing Yee So Peter C Y Tong Juliana C N Chan Chun Chung Chow 肖新华(译) 王姮(校) | 2005 | 英国医学杂志中文版2005，8，4： | 0 |
| 19 | Evaluation of Smallholder Farmers’Awareness of Cattle Diseases in Svay Rieng and Prey Veng Provinces,Cambodia显示文摘In Cambodia,cattle are used as draught power,sources of fertilizer,sources of assets,and for meat production.Due to some contagious illnesses such as hemorrhagic septicemia and foot-and-mouth disease(FMD),they mostly have low reproductivity and poor physical health.Among those diseases,brucellosis is starting to appear in cattle production in rural Cambodia and is highly transmissible to humans.Thus,the objective of this study was to evaluate the farmers’awareness of cattle diseases and their transmissibility in the country.A survey was conducted in two provinces,Svay Rieng and Prey Veng,in Cambodia,starting from July 2021 to January 2022.A sample size of 216 was randomly selected from the two provinces by using Taro Yamane,and the selection criteria were that the targeted households must have at least two cows.A pre-determined questionnaire was utilized to collect data on number of cattle,raising type,feeding system,source of cattle purchase,hygienic condition,waste management,cattle disease,body score condition and symptoms.As a result,86% of the respondents in Prey Veng province and 99.07% in Svay Rieng province have cattle disease.Smallholder farmers raise 5 to 10 cattle per household,while other farmers raise 10 to 15 calves,or 15-20 or more than 20 heads,while only 20% of smallholder farmers in Prey Veng were able to raise 5 to 10 male cattle per household.Of all the interviewees,90% recognized FMD based on clinical signs such as blisters on the feet,loss of appetite,salivation and painful,red,blister-like lesions on the tongue.Meanwhile,60% know lumpy skin disease(LSD)due to skin nodules.No one knew about brucellosis.The findings suggest that the knowledge farmers have over cattle disease is very limited and this needs more support from related institutions to raise their awareness in order to cope with cattle disease correctly and timely. | Khoeun Sokun Kong Saroeun Theng Kouch Bun Chan Ren Theary Ith Manay Chan Bunyeth Kong Sokom | 2023 | Journal of Environmental Science and Engineering(B)2023，12，1： | 0 |
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