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| 1 | Effect of Bacillus subtilis and Bacillus licheniformis supplementation in diets with low-and high-protein content on ileal crude protein and amino acid digestibility and intestinal microbiota composition of growing pigs显示文摘Background: Bacillus spp. seem to be an alternative to antimicrobial growth promoters for improving animals' health and performance. However, there is little information on the effect of Bacillus spp. in combination with different dietary crude protein(CP) levels on the ileal digestibility and microbiota composition. Therefore, the objective of this study was to determine the effect of Bacillus spp. supplementation to low-(LP) and high-protein diets(HP) on ileal CP and amino acid(AA) digestibility and intestinal microbiota composition.Methods: Eight ileally cannulated pigs with an initial body weight of 28.5 kg were randomly allocated to a rowcolumn design with 8 pigs and 3 periods of 16 d each. The assay diets were based on wheat-barley-soybean meal with two protein levels: LP(14% CP, as-fed) and HP diet(18% CP, as-fed). The LP and HP diets were supplemented with or without Bacil us spp. at a level of 0.04%(as-fed). The apparent ileal digestibility(AID) and standardized ileal digestibility(SID) of CP and AA was determined. Bacterial community composition from ileal digesta was analyzed by Illumina amplicon sequencing and quantitative real-time PCR. Data were analyzed as a 2 × 2 factorial design using the GLIMMIX procedures of SAS.Results: The supplementation with Bacillus spp. did not affect both AID and SID of CP and AA in growing pigs.Moreover, there was no difference in AID of CP and AA between HP and LP diets, but SID of cystine, glutamic acid,glycine, and proline was lower(P < 0.05) in pigs fed the HP diets. The HP diets increased abundance of Bifidobacterium spp. and Lactobacillus spp.,(P < 0.05) and by amplicon sequencing the latter was identified as predominant genus in microbiota from HP with Bacillus spp., whereas dietary supplementation of Bacillus spp. increased(P < 0.05) abundance of Roseburia spp.Conclusions: The HP diet increased abundance of Lactobacillus spp. and Bifidobacterium spp.. The supplementation of Bacil us spp. resulted in a higher abundance of healthy gut associated bacteria without affecting ileal CP and AA digestibility, whereas LP diet may reduce the flow of undigested protein to the large intestine of pigs. | Chanwit Kaewtapee Katharina Burbach Georgina Tomforde Thomas Hartinger Amelia Camarinha-Silva Sonja Heinritz Jana Seifert Markus Wiltafsky Rainer Mosenthin Pia Rosenfelder-Kuon | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 5 |
| 2 | 局部进展期直肠癌不同新辅助治疗后的病理完全缓解:一项系统综述和Meta分析显示文摘背景:局部进展期直肠癌(locally advanced rectal cancer,LARC)新辅助治疗后的病理完全缓解(pathological com⁃plete response,pCR)与更高的生存率、更少的局部复发及远处转移相关。此外,pCR意味着直肠可以被保留。这篇Me⁃ta分析概述了LARC现有的新辅助治疗策略,并分析了这些策略与标准治疗相比对实现pCR的贡献。方法:检索Pubmed、Embase和Cochrane数据库。纳入MRI分期为非转移性可切除的LARC患者接受新辅助治疗的随机对照研究。主要研究终点为pCR,定义为ypT0N0。对比较新辅助治疗与标准氟嘧啶类放化疗(chemoradiotherapy,CRT)的研究进行了Meta分析。结果:系统综述纳入的17篇文献中,11篇用于Meta分析。与仅含氟尿嘧啶的CRT相比,在基于氟尿嘧啶的CRT中添加奥沙利铂可显著提高pCR率(OR=1.46),但代价是更多的3级以上毒性反应。其他治疗策略,包括巩固/诱导化疗和短程放疗(short-chemoradiotherapy,SCRT)均没有提高pCR率。所有纳入的研究均未报告在局部控制或OS方面的获益。与CRT相比,SCRT延迟治疗的5年DFS显著恶化(HR=1.93,59%vs.75.1%)。结论:所有纳入的研究都未能提供高水平的证据表明与标准的基于氟尿嘧啶的CRT相比pCR有所改善。添加奥沙利铂可能获得更多的pCR,但以更高的毒性反应为代价。此外,这种获益并不意味着局部复发减少或生存率提高。 | 何婉 HOENDERVANGERS S BURBACH J P M LACLE M M | 2021 | 结直肠肛门外科2021，27，3： | 2 |
| 3 | How to make a mesodiencephalic dopaminergic neuron显示文摘 | Smidt M P Burbach J P | 2007 | Nat Rev Neurosci2007，8，1： | 1 |
| 4 | Homeobox gene pitx3 and its role in the development of dopamine neurons of the substantia nigra显示文摘 | Smidt M P Smits S M Burbach J P | 2004 | Cell Tissue Res2004，318，1： | 1 |
| 5 | Receptor-selective changes in mu-,delta-and kappa-opioid receptors after chronic naltrexone treatment in mice显示文摘 | Lesscher H M Bailey A Burbach J P | 2003 | Eur J Neurosci2003，17，5： | 1 |
| 6 | The impact of environmental interpretation in developing a connection to nature in park Visitors显示文摘 | BURBACH M E PENNISI L WEST C D | 2012 | LARNet-The Cyber Journal of Applied Leisure and Recreation Research2012，，： | 1 |
| 7 | Mutations in RNA: a first example of molecular misreading in alzheimer's disease 显示文摘 | Leeuwen FW Burbach PH Hol EM | 1998 | Trends Neurosci1998，21，： | 1 |
| 8 | In control of biology: of mice, men and Foxes显示文摘 | Wij chers P J Burbach JP Smidt MP | 2006 | Biochem J2006，397，2： | 1 |
| 9 | Corneal femtosecond laser keratotomy results in isolated stromal injury and favorable wound-healing response显示文摘 | Christian Meltendorf Guido J Burbach Jens Bühren | 2007 | IOVS2007，48，5： | 1 |
| 10 | Influenza vaccination in liver transplant recipients 显示文摘 | BURBACH G BIENZLE U STARK K | 1999 | Transplantation1999，67，5： | 1 |
| 11 | How to make a mesodiencephalie dop- aminergie neuron显示文摘 | Smidt MP Burbach JP | 2007 | Nat Rev Neurosci2007，8，： | 1 |
| 12 | The neurosensory tachykinins substance P and neurokinin A directly induce keratinocyte nerve growth factor显示文摘 | Burbach G J Kim KH Zivony AS | 2001 | J Invest Dermatol2001，117，5： | 1 |
| 13 | TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenie mice显示文摘 | Frank S Burbach GJ Bonin M | 2008 | Glia2008，56，13： | 1 |
| 14 | Design and Construction of the SAPHIR Detector显示文摘 | Schwille W J Bockharst M Burbach G | 1994 | Nucl Instr and Meth1994，344，： | 1 |
| 15 | Clock gene mRNA and protein rhythms in the pineal gland of mice显示文摘 | Karolczak M Burbach GJ Sties G | | 0，，12： | 1 |
| 16 | ~-actin specifically controls cell growth, migration, and the G-actin pool显示文摘 | Bunnell TM Burbach BJ Shimizu Y | 2011 | Mol BioI Cell2011，22，21： | 1 |
| 17 | Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice显示文摘 | Frank S Copanaki E Burbach G J | 2009 | Neurosci Lett2009，453，1： | 1 |
| 18 | Syndecan-1 accumulates in lysosomes of poorly differentiated breast carcinoma cells显示文摘 | Burbach BJ Friedl A | 2003 | Matrix Biol2003，22，2： | 1 |
| 19 | GA2LEN skin test study I:GA(2)LEN harmonization of skin prick testing显示文摘 | Heinzerling LM Burbach GJ Edenharter G | 2009 | Allergy2009，64，10： | 1 |
| 20 | Impact of radiotherapy boost on pathological complete response in patients with locally advanced rectal cancer: a systematic review and meta-analysis显示文摘 | Burbach JP den Harder AM Intven M | 2014 | Radiother Oncol2014，113，1： | 1 |
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