|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 重组卡介苗表达的MalE蛋白T细胞表位的鉴定显示文摘目的 鉴定重组卡介苗表达的MalE蛋白T细胞表位。方法 用抗原提呈试验、T细胞增殖试验、ELISPOT试验和表位作图测试重组MalE蛋白的T细胞表位。结果 重组BCG MalE功能性表达了MalE蛋白的 4种H 2 d 限制性T细胞表位。结论 在 4种表位中 ,p6 8~ 82是重组MalE蛋白的主要T细胞表位 ,而其余 | 焦新安 Richard Lo-man Edith Driaud Sophie Burgaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2002 | 中华微生物学和免疫学杂志2002，22，1： | 3 |
| 2 | Nitric-oxide releasing molecules: a new class of drugs with several major indications 显示文摘 | Burgaud JL Riffaud JP Del Soldato P | 2002 | Curr Pharm Design2002，8，3： | 2 |
| 3 | Nitric oxide-releasing NSAIDs:a review of their current status 显示文摘 | Iomcci S Antonelli E Burgaud JL | 2001 | Drug Saf2001，24，11： | 1 |
| 4 | Signaling requirements for the expression of the transactivating factor NF - AT in human T lymphocytes显示文摘 | Clipstone NA Cantrell DA | 1991 | European Journal of Immunology1991，21，： | 1 |
| 5 | An improved high pressure homogenizer for making fine emulsions on a small scale显示文摘 | BURGAUD I DICKINSON E NELSON P V | 1990 | International Journal of Food Science and Technology1990，25，4： | 1 |
| 6 | The PiGMaP consortium linkage map of the pig (Sus scrofa)显示文摘 | A. L. Archibald C. S. Haley J. F. Brown S. Couperwhite H. A. McQueen D. Nicholson W. Coppieters A. Weghe A. Stratil A. K. Winter? M. Fredholm N. J. Larsen V. H. Nielsen D. Milan N. Woloszyn A. Robic M. Dalens J. Riquet J. Gellin J. -C. Caritez G. Burgaud | 1995 | Mammalian Genome1995，，3： | 1 |
| 7 | Correlation between apoptosis,tumorigeneisis,and levels of insulin like growth factor 1 receptors显示文摘 | Resnicoff M Burgaud JL Rotman HL | 1995 | Cancer Res1995，55，17： | 1 |
| 8 | Nitric-oxide releasing molecules: a new class of drugs with several major indications显示文摘 | Burgaud JL Riffaud JP Del Soldato P | 2002 | Curr Pharm Des2002，8，3： | 1 |
| 9 | Nitric-oxide releasing molecules:a new class of drugs with several major indications显示文摘 | Burgaud JL Riffaud JP Del Soldato P | 2002 | Curr Pharm Des2002，8，3： | 1 |
| 10 | Nitric oxide-releasing drugs A novel class of effective and safe therapeutic agents显示文摘 | Burgaud JL Ongini E Soldato PD | 2002 | Ann N Y Acad Sci2002，962，5： | 1 |
| 11 | Nitric-oxide releasing molecules: a new class of drugs with several major indications显示文摘 | Burgaud JL Riffaud JP Del Soldato P | 2002 | Curr Pharm Des2002，8，3： | 1 |
| 12 | Correlation between apoptosis, tumorigeneisis,and levels of insulin like growth factor 1 receptors显示文摘 | Burgaud JL Rotman HL | 1995 | Cancer Res1995，55，17： | 1 |
| 13 | Nitric-oxide releasing molecules: a new class of drugs with several major indications显示文摘 | Burgaud JL | 2002 | Curr Pharm Design2002，8，3： | 1 |
| 14 | The PiGMaP consortium linkage map of the pig (Sus scrofa)显示文摘 | A. L. Archibald C. S. Haley J. F. Brown S. Couperwhite H. A. McQueen D. Nicholson W. Coppieters A. Weghe A. Stratil A. K. Winter? M. Fredholm N. J. Larsen V. H. Nielsen D. Milan N. Woloszyn A. Robic M. Dalens J. Riquet J. Gellin J. -C. Caritez G. Burgaud | 1995 | Mammalian Genome1995，，3： | 1 |
| 15 | Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor Ⅰ receptors显示文摘 | RESNICOFF M Burgaud JL Rotman HL | | 0，，： | 1 |
| 16 | Antiproliferative effects of nitrosulindac on human colon adenocarcinoma cell lines显示文摘 | Lavagna C Burgaud JL Del Soldato P | 2001 | Biochem Biophys Res Commun2001，284，3： | 1 |
| 17 | Nitric oxide-releasing NSAIDs:a review of their eurrent status显示文摘 | Fiorucci S Antonelli E Burgaud JL | 2001 | Drug Saf2001，24，11： | 1 |
| 18 | 重组卡介苗诱导T细胞免疫应答的分子、细胞机理研究显示文摘牛结核分枝杆菌BCG是世界上广泛使用的疫苗,亦被认为是表达与传递外源抗原的理想活载体之一,然而迄今对BCG或重组BCG (rBCG)与宿主免疫系统相互作用机理尚未阐明,而从免疫调节生物学角度探讨BCG或rBCG诱导T细胞应答的规律亦未涉足。为此,本研究以表达大肠杆菌MalE蛋白的rBCG (rBCC·MalE)为模型,试图阐明rBCG与抗原提呈细胞相互作用的规律、rBCG表达产物抗原表位多样性、rBCG和BCG诱导的T细胞应答规律与调控因素。 在体外抗原提呈试验中,证实rBCG·MalE成功表达MalE蛋白的四种T细胞抗原表位,即p68-82、p100-114、p151-165和p277-291。T细胞增殖试验和ELISPOT试验结果均表明这种表达是功能性的,rBCG·MalE可刺激小鼠产生MalE蛋白及其多肽特异的T细胞增殖和IFN-γ应答。表位作图显示,BCG表达的MalE未形成新的抗原表位或使隐蔽表位暴露出来,并进一步证实MalE p68-82多肽表位是MalEH-2d限制性主要T细胞表位,而p100-114、p151-165和p277-291多肽表位为次要表位。 具有抗原提呈细胞(APC)功能的吞噬性细? | 焦新安 焦新安 Richard Lo-man Pierre Guermonprez Edith Deriauf Sophie Burgaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2000 | 中国预防兽医学报2000，22，S1： | 1 |
| 19 | Pharmacokinetics of total thyroxine in dogs after administration of an oral solution of levothyroxine sodium显示文摘 | Le Traon G Burgaud S Horspool L J | 2008 | J Vet Pharmacol Ther2008，31，2： | 1 |
| 20 | The PiGMaP consortium linkage map of the pig (Sus scrofa)显示文摘 | A. L. Archibald C. S. Haley J. F. Brown S. Couperwhite H. A. McQueen D. Nicholson W. Coppieters A. Weghe A. Stratil A. K. Winter? M. Fredholm N. J. Larsen V. H. Nielsen D. Milan N. Woloszyn A. Robic M. Dalens J. Riquet J. Gellin J. -C. Caritez G. Burgaud | 1995 | Mammalian Genome1995，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员