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| 1 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 2 | Use of multiplebimarkers for a molecular diagnosis of prostate cancer 显示文摘 | Landers KA Burger MJ Tebay MA | 2005 | Int J Cancer2005，114，6： | 1 |
| 3 | Treatment of radiation- induced nervous system injury with heparin and warfarin 显示文摘 | Glantz MJ Burger PC Friedman AH | 1994 | Neurology1994，44，11： | 1 |
| 4 | Use of multiple biomarkers for a molecular diagnosis of prostate cancer 显示文摘 | Landers KA Burger MJ Tebay MA | 2005 | Int J Cancer2005，114，6： | 1 |
| 5 | Effectiveness of neuronavigation in resecting solitary intracerebral contrast-enhancing tumors:a randomized controlled trial显示文摘 | Willems PW Taphoorn MJ Burger H | 2006 | J Neurosurg2006，104，3： | 1 |
| 6 | Treatment of radiation- induced nervous system injury with heparin and warfarin显示文摘 | Glantz MJ Burger PC Friedman AH | 1994 | Neurology1994，44，： | 1 |
| 7 | Herpes simplex virus-1 encephali- tis : a review of current disease management with three case reports 显示文摘 | Skelly MJ Burger AA Adekola O | 2012 | Antivir Chem Chemother2012，23，1： | 1 |
| 8 | Expression analysis of deltacatenin and prostate-specific membrane antigen:their potential as diagnostic markers for prostate cancer显示文摘 | Burger MJ Tebay MA Keith PA | | 0，，02： | 1 |
| 9 | Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1,2 and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system显示文摘 | Burger C Gorbatyuk OS Velardo MJ | | 0，，： | 1 |
| 10 | Treatment of radiationinduced nervous ystem injury with heparin and warlarin 显示文摘 | Glantz MJ Burger PC Friedman Ah | 1994 | Neurology1994，44，11： | 1 |
| 11 | Expression analysis of delta-catenin and prostate-specific membrane antigen: their potential as diagnostic markers for prostate cancer 显示文摘 | Burger MJ Tebay MA Keith PA | 2002 | Int J Cancer2002，100，： | 1 |
| 12 | Can elective nodal irradiation be omitted in stage non-small cell lung cancer?Analysis of recurrences in a phase study of in duction chemotherapy and involved field radio-therapy显示文摘 | Senan S Burgers S Samson MJ | 2002 | Int J Radiat Oncol Biol Phys2002，54，11： | 1 |
| 13 | In Vivo comparison of working Length determination with two electronic apex locators显示文摘 | Wrbas KT Ziegler AA Altem burger MJ | 2007 | Int Endod J2007，40，2： | 1 |
| 14 | Treatment of radiation-induced nervous system injury with heparin and warfarin 显示文摘 | Glantz MJ Burger PC Friedman AH | 1994 | Neurology1994，44，11： | 1 |
| 15 | Expression analysis of δ-catenin and prostate-specific membrane antigen: their potential as diagnostic markers for prostate cancer显示文摘 | Burger MJ Tebay MA Keith PA | 2002 | Int J Cancer2002，100，2： | 1 |
| 16 | Safety and activity of Ibrutinib plus Rituximab for patients with high-risk chronic lymphocytic leukaemia: A single-arm, phase 2 study显示文摘 | Burger JA Keating MJ Wierda WG | 2014 | Lancet Oncol2014，15，10： | 1 |
| 17 | Can elective nodal irradiation be omitted in stage Ⅲ non-small-cell lung cancer? Analysis of recurrences in a phase Ⅱ study of induction chemotherapy and involved field radio-therapy 显示文摘 | Senan S Burgers S Samson MJ | 2002 | Int J Radiat Oncol Biol Phys2002，54，11： | 1 |
| 18 | Ibrutinib incombination with rituximab (iR) is well tolerated and induces ahigh rate of durable remissions in patients with high-risk chroniclymphocytic leukemia ( CLL) : new, updated results of a Phase IItrial in 40 patients 显示文摘 | BURGER JA KEATING MJ WIERDA WG ef al | 2013 | Blood (ASH Annual Meeting Abstracts)2013，122，21： | 1 |
| 19 | Use of multiple biomarkers for amolecular diagnosis of prostate cancer 显示文摘 | Landers KA Burger MJ Tebay MA | 2005 | Int J Cancer2005，114，6： | 1 |
| 20 | Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1,2,and 5 display differential efficiency and celltropism after delivery to different regions of the centralnervous system显示文摘 | Burger C Gorbatyuk OS Velardo MJ | | 0，，02： | 1 |
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