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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Efficacy of spinal cord stimulation:10 years experience in a pain centre in Belgium显示文摘 | Buyten JPV Zundert JV Vueghs P | 2001 | Eur J Pain2001，5，： | 1 |
| 3 | Long chain alkyl-polysiloxanes as non-polar stationary phases in capillary gas chromatography显示文摘 | Karlheinz Ballschmiter Angela Mennel Jan Buyten | 1993 | Fresenius’ Journal of Analytical Chemistry1993，，4： | 1 |
| 4 | Neurostimulatian for chronic neuropathie back pain in failed back surgery syndrome显示文摘 | Van Buyten JP | 2006 | J Pain Symptom Manage2006，31，4： | 1 |
| 5 | Fresenius' Journal of Analytical Chemistry显示文摘 | Ballschmiter Karlheinz Mennel Angela Jan Buyten | 1993 | 346(4) :3961993，346，4： | 1 |
| 6 | Spinal cord stimulation for chronic back and leg pain and failed back surgery syndrome: a systematic review and analysis of prognostic factors 显示文摘 | Taylor RS Van Buyten JP Buchser E | 2005 | Spine2005，30，1： | 1 |
| 7 | Brassinosteroids antagonize gibberellin-and salicylate-mediated root immunity in rice显示文摘 | DE VLEESSCHAUWER D VAN BUYTEN E SATOH K BALIDION J MAULEON R CHOI I VERA-CRUZ C KIKUCHI S HFTE M | 2012 | Plant Physiology2012，158，4： | 1 |
| 8 | Neurostimulation for chronic neuropathic back pain in ailed back surgery syndrome显示文摘 | Van Buyten JP | 2006 | J Pain Symptom Manage2006，31，4： | 1 |
| 9 | Spinal cord stimulation for complex regional pain syndrome:a systematic review of the clinical and cost - effectiveness literature and assessment of prognostic factors 显示文摘 | Taylor RS Van Buyten JP Buchser E | 2006 | Eur J Pain2006，10，2： | 1 |
| 10 | Spinal cord stimulation for chronic back and leg pain and failed back surgery syndrome:a systematic review and analysis of prognostic factors显示文摘 | Taylor RS van Buyten JP Buchser E | 2005 | Spine2005，30，： | 1 |
| 11 | High-frequency spinal cord stimulation for the treatment of chronic back pain patients:results of a prospective multicenter European clinical study显示文摘 | Van Buyten JP Al-Kaisy A Smet I | | 0，，： | 1 |
| 12 | Spinal cord stimulation for chronic back and leg pain and failed back surgery syndrome: a systematic review and analysis of prognostic factors 显示文摘 | Taylor RS Van Buyten JP Buchser E | 2005 | Spine ( Phila Pa 1976)2005，30，： | 1 |
| 13 | High-frequency spinal cord stimulation for the treatment of chronic back pain patients:resuhs of a prospective muhicenter European clinical study 显示文摘 | Van Buyten JP A1-Kaisy A Smet I | 2013 | Neuromodulation2013，16，1： | 1 |
| 14 | Sustained Effec- tiveness of 10 kHz High-Frequency Spinal Cord Stimulation for Patients with Chronic, Low Back Pain:24-Month Re- suits of a Prospective Muhieenter Study显示文摘 | A1-Kaisy A Van Buyten JP Smet I | 2013 | Pain Med2013，，12： | 1 |
| 15 | Spinal cord stim- ulation for complex regional pain syndrome: a systematic re- view of the clinical and eost-effectiveness literature and assessment of prognostic factors显示文摘 | Taylor RS Van Buyten JR Buscher E | 2006 | Eur J Pain2006，0，2： | 1 |
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