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| 1 | Leptin levels in the differential diagnosis between benign and malignant ascites显示文摘AIM: To evaluate the role of leptin levels in the differential diagnosis of ascites. METHODS: Ascitic leptin, TNFα and serum leptin levels were measured in 77 patients with ascites (35 with malignancies, 30 cirrhosis and 12 tuberculosis). Control serum samples were obtained from 20 healthy subjects. Leptin and TNFα levels were measured by ELISA. Body mass index (BMI) and percentage of body fat (BFM) by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients. RESULTS: In patients with malignancies, the mean serum and ascites leptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFα levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls. CONCLUSION: In patients with malignant ascites, levels of leptin and TNFα were significantly lower than in patients with tuberculous ascites. | Mehmet Buyukberber Mehmet Koruk M Cemil Savas Murat T Gulsen Yavuz Pehlivan Rukiye Deveci Alper Sevinc Serdar Gergerlioglu | 2007 | World Journal of Gastroenterology2007，13，3： | 7 |
| 2 | Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis显示文摘AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP).METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased signif icantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathologicalresults and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of benef icial effects of CAPE before clinical usage of this agent. | Mehmet Buyukberber M Cemil Savas Cahit Bagci Mehmet Koruk Murat T Gulsen Ediz Tutar Tugba Bilgic Nurdan Ceylan | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 3 | The relation between plasma endothelin-1 levels and metabolic control,risk factors,treatment modalities,and diabetic microangiopathy in patients with Type 2 diabetes mellitus显示文摘 | Ak G Buyukberber S Sevinc A | 2001 | Diabetes Complications2001，15，3： | 1 |
| 4 | Serum CA 125 levels in patients with chronic heart failure and accompanying pleural fluid 显示文摘 | Turk HM Pekdemir H Buyukberber S | 2003 | Tumour Siol2003，24，4： | 1 |
| 5 | Efficacy and toxicity of preoperative chemotherapy with docetaxel and epirubicin in locally advanced invasive breast cancer显示文摘 | Kaya AO Coskun U Buyukberber S | | 0，，02： | 1 |
| 6 | Overexpression of cyclooxygenase - 2 in multiple myeloma: Association with reduced survival 显示文摘 | Cetin M Buyukberber S Demir M | 2005 | Am J Hematol2005，80，3： | 1 |
| 7 | Efficacy and toxicityof gemcitabine plus docetaxel combination as a second line thera-py for patients with advanced stage soft tissue sarcoma显示文摘 | Kaya AO Buyukberber S Ozkan M | 2012 | AsianPac J Cancer Prev2012，13，2： | 1 |
| 8 | Efficacy and safety of concomitant chemoradiotherapy with Cisplatin and docetaxel in patients with locally advanced squamous cell head and neck cancers显示文摘 | Baykara M Buyukberber S Ozturk B | 2013 | Asian Pac J Cancer Prev2013，14，4： | 1 |
| 9 | Concomitant chemora- diotherapy with cisplatin and docetaxel followed by surgery and consohdation chemotherapy in patients with unresectable locally advanced non-small cell lung cancer显示文摘 | Kaya AO Buyukberber S Benekli M | 2009 | Med Oncol2009，2，： | 1 |
| 10 | Overexpression of cyclooxygenase-2 in multiple myeloma: association with reduced survival 显示文摘 | Cetin M Buyukberber S Demir M | 2005 | Am J Hematol2005，80，3： | 1 |
| 11 | Serum CA 125 levels in patients with chronic heart failure and accompanying pleural fluid显示文摘 | Turk H M Pekdemir H Buyukberber S | 2003 | Tu- mottr Biol2003，24，4： | 1 |
| 12 | Trabectedin in advanced soft tissue sarcoma: case series 显示文摘 | Demirci U Buyukberber S Yetisyigit T | 2012 | J BUON2012，17，3： | 1 |
| 13 | The relation between plasma endothelin-1 levels and metabolic control, risk factors, treatment modalities, and diabetic microangiopathy in patients with Type 2 diabetes mellitus显示文摘 | Ak G Buyukberber S Sevinc A | 2001 | Diabetes Complications2001，15，3： | 1 |
| 14 | Elevated serum CA-125 levels in hemodialysis patients with peritoneal,pleural,or pericardial fluids显示文摘 | Sevinc A Buyukberber S Sari R | 2000 | Gynecol Oncol2000，77，： | 1 |
| 15 | Elevated serum CA-125 levels in patients with nephrotic syndrome-induced ascites显示文摘 | Sevinc A Buyukberber S Sari R | 2000 | Anticancer Res2000，20，： | 1 |
| 16 | Elevated serum CA-125 levels in patients with nephrotic syndrome-induced ascites显示文摘 | Alper Sevinc Suleyman Buyukberber Ramazan Sari | 2000 | Anticancer Res2000，20，： | 1 |
| 17 | Cisplatin plus docetaxel combination in the first-line treatment of metastatic non-small cell lung cancer显示文摘 | Kaya AO Buyukberber S Dane F | 2010 | Tumori2010，96，3： | 1 |
| 18 | The relation between plasma endothelin-1 levels and metabolic control, risk factors, treatment modalities, and diabetic microangiopathy in patients with type 2diabetes mellitus显示文摘 | Ak G Buyukberber S Sevinc A | 2001 | J Diabetes Complications2001，15，3： | 1 |
| 19 | Serum CA 125 lev els in patients wilh chronic heart failure and accompanying pleural fluid显示文摘 | Turk HM Pekdemir H Buyukberber S etal | 2003 | Tumour Biol2003，24，4： | 1 |
| 20 | The relation between plasma endothelin-1 levels and metabolic control,risk factors,treatment modalities,and diabetic microangiopathy in patients with type 2 diabetes mellitus显示文摘 | Ak G Buyukberber S Sevinc A | 2001 | J Diabetes Complications2001，15，： | 1 |
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