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| 1 | Impact of inflammatory bowel disease activity and thiopurine therapy on birth weight: A meta-analysis显示文摘AIM To investigate the effect of disease activity or thiopurine use on low birth weight and small for gestational age in women with inflammatory bowel disease(IBD).METHODS Selection criteria included all relevant articles on the effect of disease activity or thiopurine use on the risk of low birth weight(LBW) or small for gestational age(SGA) among pregnant women with IBD. Sixtynine abstracts were identified,35 papers were full text reviewed and,only 14 of them met inclusion criteria. Raw data were extracted to generate the relative risk of LBW or SGA. Quality was assessed using the Newcastle Ottawa Scale.RESULTS This meta-analysis is reported according to PRISMA guidelines. Fourteen studies met inclusion criteria,and nine reported raw data suitable for meta-analysis. We found an increased risk ratio of both SGA and LBW in women with active IBD,when compared with women in remission: 1.3 for SGA(4 studies,95%CI: 1.0-1.6,P = 0.04) and 2.0 for LBW(4 studies,95%CI: 1.5-2.7,P < 0.0001). Women on thiopurines during pregnancy had a higher risk of LBW(RR 1.4,95%CI: 1.1-1.9,P = 0.007) compared with non-treated women,but when adjusted for disease activity there was no significant effect on LBW(RR 1.2,95%CI: 0.6-2.2,P = 0.6). No differences were observed regarding SGA(2 studies; RR 0.9,95%CI: 0.7-1.2,P = 0.5). CONCLUSION Women with active IBD during pregnancy have a higher risk of LBW and SGA in their neonates. This should be considered in treatment decisions during pregnancy. | Begona Gonzalez-Suarez Shreyashee Sengupta Alan C Moss | 2017 | World Journal of Gastroenterology2017，23，45： | 3 |
| 2 | Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system显示文摘 | Strappe P M Hampton D W Begona C G | 2005 | Eur J Pharm Biopharm2005，61，3： | 1 |
| 3 | Biosimilars approval process 显示文摘 | Leyre Z Begona C | 2010 | Reg Toxicol Pharmacol2010，，56： | 1 |
| 4 | Competitive versus efficient extrac tion of a common property resource: the ground water case 显示文摘 | Rubio J Santiago C Begona | 2001 | Journal of Economic Dynamics and Control2001，25，11： | 1 |
| 5 | Impact of high-pressure and traditional thermal processing of tomato puree on carotenoids, vitamin C and antioxidant activity显示文摘 | Sanchez-Moreno C Plaza L Begona de Ancos | 2006 | Journal of the Science of Food and Agriculture2006，86，2： | 1 |
| 6 | Commereial dietary antioxidant supplement sassayed for their antioxidant activity by different methodologies显示文摘 | ALBERTO D CARMEN G C BEGONA B | 2003 | Journal of Agricultural and Food Chemistry2003，51，： | 1 |
| 7 | Enhancement of anthocyanins and selected aroma compounds in strawberry fruits through methyl jasmonate vapor treatment显示文摘 | FERNANDO de la P M MARIA M GRACIA P B BEGONA B MARIA L R del C | 2010 | Eur Food Res Technol2010，230，： | 1 |
| 8 | An intelligent system for false alarm reduction in infrared forest-fire detection显示文摘 | Begona C Arrue Anibal Ollero J Ramiro Martinez de Dios | 2000 | Intelligent Systems2000，15，3： | 1 |
| 9 | Evaluation of the biological properties of soluble chitosan and chitosan microspheres 显示文摘 | BEGONA C G RUTH D | 1997 | International Journal of Pharmaceutics1997，148，： | 1 |
| 10 | Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficient显示文摘 | Elisabeth C Begona C Daniel G N | 2003 | J Nephrol2003，16，3： | 1 |
| 11 | Impact of high-pressure and traditional thermal processing of tomato puree oncarotenoids, vitamin C and antioxidant activity显示文摘 | Sanchez-Moreno C Plaza L Begona de Ancos | 2006 | Journal of the Science of Food and Agriculture2006，86，： | 1 |
| 12 | Protein disulfide isomer- ase: the structure of oxidative folding 显示文摘 | Christian W G Masa C Begona H | 2006 | Trends Biochem Sci2006，31，8： | 1 |
| 13 | Vigor and dedication innursing professionals:towards a better understanding of work engagement 显示文摘 | Jenaro C Flores N Begona M | 2011 | J Adv Nurs2011，67，4： | 1 |
| 14 | Vigor and dedication in nursing professionals:towards a better understanding of work engagement显示文摘 | Jenaro C Flores N Begona M et at | 2011 | J Adv Nurs2011，67，4： | 1 |
| 15 | Exposure of women to organochlorine pesticides in southern spain显示文摘 | Jorge C Ana R | 2004 | Environ Res2004，96，： | 1 |
| 16 | Role of capsule endoscopy in suspected celiac disease: A European multi-centre study显示文摘AIM To analyze the diagnostic yield(DY), therapeutic impact(TI) and safety of capsule endoscopy(CE).METHODS This is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease(CD)(mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy(Group-Ⅰ, n = 19), seropositive CD without atrophy(Group-Ⅱ, n = 39), contraindication to gastroscopy(Group-Ⅲ, n = 6), seronegative CD without atrophy, but with a compatible context(Group-Ⅳ, n = 99). DY, TI and the safety of CE were analysed.RESULTS The overall DY was 54% and the final diagnosis was villous atrophy(n = 65, 39.9%), complicated CD(n = 12, 7.4%) and other enteropathies(n = 11, 6.8%; 8 Crohn's). DY for groups Ⅰ to Ⅳ was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases(36.9%), diffuse in 19(29.2%), jejunal in 11(16.9%), and patchy in 10 cases(15.4%). Factors associated with a greater DY were positive serology(68.3% vs 49.2%, P = 0.034) and older age(P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE resultschanged the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI(92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention(0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated CD.CONCLUSION CE has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD. | Marisol Luján-Sanchis Enrique Pérez-Cuadrado-Robles Javier Garcia-Lledo José-Francisco Juanmartinena Fernandez Luca Elli Victoria-Alejandra Jiménez-García Juan Egea-Valenzuela Julio Valle-Munoz Cristina Carretero-Ribón Ignacio Fernández-Urién-Sainz Antonio López-Higueras Noelia Alonso-Lazaro Mileidis Sanjuan-Acosta Francisco Sanchez-Ceballos Bruno Rosa Santiago González-Vázquez Federica Branchi Lucía Ruano-Díaz César Prieto-de-Frías Vicente Pons-Beltrán Pilar Borque-Barrera Begona González-Suárez Sofía Xavier Federico Argüelles-Arias Juan-Manuel Herrerías-Gutiérrez Enrique Pérez-Cuadrado-Martínez Javier Sempere-García-Argüelles | 2017 | World Journal of Gastroenterology2017，23，4： | 0 |
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