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| 1 | Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. | H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani | 2007 | World Journal of Gastroenterology2007，13，17： | 6 |
| 2 | Pulmonary fibrosis correlates with outcome in the adult respiratory dis- tress syndrome显示文摘 | Martin C Papazian L Payan M J | 1995 | Chest1995，107，1： | 1 |
| 3 | Comparative evaluation of the total hepatitis C virus core antigen, branched-DNA, and amplicor monitor assays in determining viremia for patients with chronic hepatitis C during interferon plus ribavirin combination therapy 显示文摘 | VEILLON P PAYAN C PICCHIO G | 2003 | J Clin Microbiol2003，41，： | 1 |
| 4 | Group connectivity of graphs-a nonhomogeneous analogue of nowhere-zero flow properties 显示文摘 | JAEGER F LINIAL N PAYAN C | 1992 | J Combinatorial Theory:Ser B1992，56，： | 1 |
| 5 | A property on edge-disjoint spanning trees 显示文摘 | LAI Hongjian LAI Hongyuan PAYAN C | 1996 | European J Combin1996，17，： | 1 |
| 6 | Layer by layer buildup of polysaccharide films: physical chemistry and cellular adhesion aspects 显示文摘 | Richert L Lavalle P Payan E Shu XZ Prestwish GD Stohz J-F Schaaf P Voegel JC Picart C | 2004 | Langmuir2004，20，： | 1 |
| 7 | Comparison of linearand non-linear soft tissue models with post-operative CT scan inmaxillofacial surgery显示文摘 | Chabanas M Payan Y Marecaux C | 2004 | Int Symp Med Simul2004，3078，： | 1 |
| 8 | Comparative evaluation of the total hepatitis C:virus core antigen,branched DNA,and amplicor monitor assays in determining viremia for patients with chronic hepatitis C during interferon plus ribavirin combination therapy显示文摘 | Veillon P Payan C Picchio G | 2003 | J Clin Microbiol2003，41，7： | 1 |
| 9 | Automated percutaneous lumbar discectomy versus chemonucleolysis in the treatment of sciatica: A randomized muhicenter trial显示文摘 | Revel M Payan C Vallee C | 1993 | Spine1993，18，： | 1 |
| 10 | Potential of non- linear ultrasonic indicators for nondestructive testing of concrete显示文摘 | PAYAN C GARNIER V MOYSAN J | 2010 | Advances in Civil Engineering2010，，： | 1 |
| 11 | Stimulation of transcriptional regulatory activity by substance P显示文摘 | Christian C Gilbert M Payan DG | 1994 | Neuroimmunomodulation1994，1，3： | 1 |
| 12 | Anhedonia and relapse in alcoholism显示文摘 | Marra D Warot D Payan C | 1998 | Psychiatry Res1998，80，： | 1 |
| 13 | Neuromotor development and language processing in developmental dyspraxia: a followup case study显示文摘 | Le N M T Vaivre D L Payan C | 2000 | J Clin Exp Neuropsychol2000，22，3： | 1 |
| 14 | Endothelial cells grown on thin polyelectrolyte multilayered films: an luatlon of a new versatile surface modification显示文摘 | Boura C Menu P Payan E | 2003 | Biomaterials2003，24，： | 1 |
| 15 | Inactivation of hepatitis B virus in plasma by hospital in - use chemical disinfectants assessed by a medi- fled HepG2 cell culture显示文摘 | Payan C Cottin J Lemafie C | 2001 | J Hosp Infec2001，47，： | 1 |
| 16 | Assessment of new chemical disin- fectauts for HBV virucidal activity in a cell culture model显示文摘 | Payan C Pivert A KampfG | 2004 | J Hosp Infec2004，56，： | 1 |
| 17 | Determination of Nonlinear Elastic Constants and Stress Monitoring in Concrete by Coda Waves Analysis 显示文摘 | PAYAN C GARNIER V MOYSAN J | 2010 | European Journal of Environmental & Civil Engineering2010，3，1： | 1 |
| 18 | Human Papillomavirus Quantification in Urine and Cervical Samples by Using the Mx 4000 and Light Cycler General Real - Time PCR Systems 显示文摘 | Payan C Ducancelle A Aboubaker MH | 2007 | J Clin Microbio2007，45，3： | 1 |
| 19 | Automated percutaneous lumbar discectomy versus chemonucleolysis in the treatment of sciatica显示文摘 | Revel M Payan C Vallee C | 1993 | Spine1993，18，： | 1 |
| 20 | Carbonation assessment in concrete by nonlinear ultrasound 显示文摘 | Bouchaala F Payan C Gamier V | 2011 | Cement and Concrete Research2011，41，： | 1 |
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