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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 巨峰和无核早红葡萄在越南谅山试种观察显示文摘[目的]观察巨峰、无核早红葡萄在越南谅山省的引种表现,为其在越南推广种植提供参考依据.[方法]2009年春从中国南宁引入巨峰、无核早红两个鲜食葡萄品种在越南谅山省试种,调查其枝蔓生长量、物候期、果实性状、产量等相关指标.[结果]至第1年抚育冬季,巨峰葡萄枝蔓总长234.5 cm,上架茎粗0.84 cm;无核早红葡萄枝蔓总长294.1 cm,上架茎粗0.86 cm.在物候期方面,巨峰葡萄从萌芽至果实成熟需141~151 d,表现中熟;无核早红从萌芽至果实成熟需142~151 d,未表现其应有的早熟特性.在果实性状方面,巨峰葡萄2010~2012年3年平均单果重8.9 g,种子数1.04粒,可溶性固形物(TSS)含量17.5%;无核早红葡萄2010~2012年3年平均单果重6.8 g,TSS含量13.9%.在产量方面,巨峰葡萄2010~2012年产量分别为13.69、17.50和16.24 t/ha;无核早红葡萄2010~2012年产量分别为10.81、16.02和20.92t/ha.[结论]巨峰葡萄在越南谅山省种植表现丰产稳产优质,具有较好的适栽性,可大面积推广种植;无核早红葡萄表现丰产稳产,但表现低糖低酸,极易裂果,着色困难,不宜在越南大面积发展. | 黄江流 PHAM Thi Thang 罗瑞鸿 NGUYN Thi Hà 吕荣华 LUONG Dǎng Ning CHU Vǎn DUòng NGUYN Manh Tòng 彭宏祥 Ly Ming Nguyet LU'O'NG i Thuy CHU Xun Tien VI Vǎn Dúc NGUYN Duy Dng Ly Dúc Khiêm 熊俏 | 2014 | 南方农业学报2014，45，7： | 5 |
| 3 | Design, fabrication and testing of a composite bracket for aerospace applications 显示文摘 | Thuis H G S J Biemans C | 1997 | Composite Structures1997，38，14： | 1 |
| 4 | Waveguide-to-Microstrip Transition for Milimeter-Wave Applications 显示文摘 | YI C S THUY N T | 1988 | IEEE Transactions on Microwave Theory and Techniques1988，36，3： | 1 |
| 5 | Experience with the Jostra Rotaflow and QuadroxD oxygenator for ECMO显示文摘 | C Thuys M Bennett | 2004 | Perfusion2004，19，1： | 1 |
| 6 | Immunosuppressive auronol glycosides from Artocarpus tonkinensis 显示文摘 | Thuy TT Kamperdick C Ninh PT | 2004 | Phannazie2004，59，4： | 1 |
| 7 | Impact of compost, vermicompost and biochar on soil fertility, maize yield and soil erosion in Northern Vietnam: a three year mesocosm experiment显示文摘 | Thuy T D Henry-Des-Tureaux T Rumpel C | 2015 | Sci Total Environ2015，514，： | 1 |
| 8 | To what extent are pesticides removed from surface water during co- agulation-flocculation显示文摘 | Pham Thi Thuy K Moons J C van Dijk | 2008 | Water and Environment Journal2008，22，3： | 1 |
| 9 | Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly (ADP-ribosyl) ation in cultured human cells 显示文摘 | Walter I Schwerdtle T Thuy C | 2007 | DNA Repair(Amst)2007，6，1： | 1 |
| 10 | Maize association population: a high-resolution platform for quantitative trait locus dissection 显示文摘 | Flint-Garcia S A Thui|let A C Yu J Pressoir G Romero S M Mitchell S E Doebley J Kresovich S Goodman M M Buckler E S | 2005 | The Plant Journal2005，44，6： | 1 |
| 11 | Genotoxicity of solu-ble and particulate cadmium compounds : impact on oxida-tive DNA damage and nucleotideexcision repair 显示文摘 | Schwerdtle T Ebert F Thuy C | 2010 | ChemRes Toxicol2010，23，： | 1 |
| 12 | Synthesis of CuS and CuS/ZnS core/shell nanocrystals for photocatalytic degradation of dyes under visible light显示文摘 | Thuy U T D Liem N Q Parlett C | 2014 | Catalysis Communications2014，44，： | 1 |
| 13 | Dual enlargement of gold nanoparticles:from mechanism to scanometric detection of pathogenic bacteria显示文摘 | Cao C Gontard LC Thuy Tramle L | 2011 | Small2011，7，： | 1 |
| 14 | Exploring the Staging Patterns of MNC Entry to New Markets:The Resource Leverage Approach显示文摘This study aims at providing explanations for how MNCs(multinational companies)proceed with their manipulation of resources and competencies in the entry process to a foreign market.To an increasing extent,such processes perform as a staging process of resource leverage.This study identifies three stages,using the multiple case study incorporating grounded theory:the initial stage,the adaptive intensification stage,and the advantage persistence stage.In the initial stage,an MNC’s entry decision tends to be based on the resource replication mode of resource leverage;the resource exploitation mode of resource leverage is used mainly in the adaptive intensification stage,and the resource exploration mode is used in the advantage persistence stage.This study suggests that these resource leverage modes incorporating their microfoundations can be viewed as a set of potential measurements for examining MNCs'dynamic capabilities in the entry process to a new host market. | Tung-Shan Liao ThịNgọc Duy Trần Thi Thuy Dung Pham | 2021 | Journal of Business Administration Research2021，4，3： | 0 |
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