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| 1 | 在AIDS病人和非AIDS的卡波西肉瘤病人中检测HHV-8基因和抗体显示文摘在AIDS病人和非AIDS的卡波西肉瘤病人中检测HHV-8基因和抗体滕智平冯加武王爱霞王自春余红徐莲芝C.Wood耿运琪曾毅作者单位:100052北京中国预防医学科学院病毒学研究所(滕智平王自春曾毅);天津南开大学生命科学院(冯加武耿运琪);广州海员... | 滕智平 冯加武 王爱霞 王自春 余红 徐莲芝 C.Wood 耿运琪 曾毅 | 1998 | 中华实验和临床病毒学杂志1998，12，1： | 5 |
| 2 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 3 | “参阳”方辅助治疗口腔鳞状细胞癌的远期疗效评价显示文摘目的本研究旨在进一步评价综合序列治疗中加用中药“参阳”方对口腔鳞状细胞癌(简称鳞癌)患者的远期疗效。方法本组病例系初发口腔鳞癌患者,共238例。随机分为治疗组(参阳方)与对照组(安慰剂)。剔除术后未服满中药3个月患者17例,术后失访8例,实际研究病例数213例。其中治疗组104例,对照组109例。全组病例均经过5~10a以上随访(随访率为96.44%)。数据用Logrank法进行统计分析。结果“参阳”方组的3、5、8、10a生存率分别较对照组提高8.46%、9.26%、9.04%、8.57%,经统计学处理,P=0.1936,P>0.05,实际数据有延长生存率的趋势。结论术后服中药“参阳”方,有明显提高口腔鳞癌患者生存率的趋向,可作为综合序列治疗的辅助方法之一。 | 林国础 邱蔚六 陆昌语 郭一钦 曹阳 Walter.Guralnick Chung-Cheng.Hsich Thomas Albert Williarm C.Wood Edward Everts | 2003 | 上海口腔医学2003，12，5： | 2 |
| 4 | Efficient and interpretable graph network representation for angle-dependent properties applied to optical spectroscopy显示文摘Graph neural networks are attractive for learning properties of atomic structures thanks to their intuitive graph encoding of atoms and bonds.However,conventional encoding does not include angular information,which is critical for describing atomic arrangements in disordered systems.In this work,we extend the recently proposed ALIGNN(Atomistic Line Graph Neural Network)encoding,which incorporates bond angles,to also include dihedral angles(ALIGNN-d).This simple extension leads to a memory-efficient graph representation that captures the complete geometry of atomic structures.ALIGNN-d is applied to predict the infrared optical response of dynamically disordered Cu(II)aqua complexes,leveraging the intrinsic interpretability to elucidate the relative contributions of individual structural components.Bond and dihedral angles are found to be critical contributors to the fine structure of the absorption response,with distortions that represent transitions between more common geometries exhibiting the strongest absorption intensity.Future directions for further development of ALIGNN-d are discussed. | Tim Hsu Tuan Anh Pham Nathan Keilbart Stephen Weitzner James Chapman Penghao Xiao S.Roger Qiu Xiao Chen Brandon C.Wood | 2022 | npj Computational Materials2022，，1： | 1 |
| 5 | Pancreatic iron and glucose dysregulation in thalassemia major显示文摘 | Leila J.Noetzli Steven D.Mittelman Richard M.Watanabe Thomas D.Coates John C.Wood | 2012 | Am. J. Hematol2012，，2： | 1 |
| 6 | The Arabidopsis FLC protein interacts directly in vivo with SOC1 and FT chromatin and is part of a high‐molecular‐weight protein complex显示文摘 | Craig C.Wood MasumiRobertson W.James Peacock Elizabeth S.Dennis | 2006 | The Plant Journal2006，，2： | 1 |
| 7 | fficient and universal characterization of atomic structures through a topological graph order parameter显示文摘A graph-based order parameter,based on the topology of the graph itself,is introduced for the characterization of atomistic structures.The order parameter is universal to any material/chemical system and is transferable to all structural geometries.Four sets of data are used to validate both the generalizability and accuracy of the algorithm:(1)liquid lithium configurations spanning up to 300 GPa,(2)condensed phases of carbon along with nanotubes and buckyballs at ambient and high temperature,(3)a diverse set of aluminum configurations including surfaces,compressed and expanded lattices,point defects,grain boundaries,liquids,nanoparticles,all at nonzero temperatures,and(4)eleven niobium oxide crystal phases generated with ab initio molecular dynamics.We compare our proposed method to existing,state-of-the-art methods for the cases of aluminum and niobium oxide.Our order parameter uniquely classifies every configuration and outperforms all studied existing methods,opening the door for its use in a multitude of complex application spaces that can require fine structure-level characterization of atomistic graphs. | James Chapman Nir Goldman Brandon C.Wood | 2022 | npj Computational Materials2022，，1： | 0 |
| 8 | Microstructural impacts on ionic conductivity of oxide solid electrolytes from a combined atomistic-mesoscale approach显示文摘Although multiple oxide-based solid electrolyte materials with intrinsically high ionic conductivities have emerged,practical processing and synthesis routes introduce grain boundaries and other interfaces that can perturb primary conduction channels.To directly probe these effects,we demonstrate an efficient and general mesoscopic computational method capable of predicting effective ionic conductivity through a complex polycrystalline oxide-based solid electrolyte microstructure without relying on simplified equivalent circuit description.We parameterize the framework for Li_(7-x)La_(3)Zr_(2)0_(12)(LLZO)gamet solid electrolyte by combining synthetic microstructures from phase-field simulations with diffusivities from molecular dynamics simulations of ordered and disordered systems.Systematically designed simulations reveal an interdependence between atomistic and mesoscopic microstructural impacts on the effective ionic conductivity of polycrystalline LLZO,quantified by newly defined metrics that characterize the com plex ionic transport mechanism.Our results provide fundamental understanding of the physical origins of the reported variability in ionic conductivities based on an extensive analysis of literature data,while simultaneously outlining practical design guidance for achieving desired ionic transport properties based on conditions for which sensitivity to microstructural features is highest.Additional implications of our results are discussed,including a possible connection between ion conduction behavior and dendrite formation. | Tae Wook Heo Andrew Grieder Bo Wang Marissa Wood Tim Hsu Sneha A.Akhade Liwen F.Wan Long-Qing Chen Nicole Adelstein Brandon C.Wood | 2021 | npj Computational Materials2021，，1： | 0 |
| 9 | 牛免疫缺陷病毒反式激活因子功能域的研究显示文摘Transactivator (Tat) of bovine immunodeficiency virus (BIV) is a virus encoded regulatory protein, which activates gene expression directed by BIV long terminal repeat (LTR), and plays an important role in BIV replicative cycle. With methods of fusion protein expression and deletion mutation, a set of BIV Tat deletion mutants was constructed, and co transfected into FBL cells with BIV LTR. Using luciferase gene as a reporter, the function of BIV Tat mutants was detected and it showed that: 17/96 aa region of BIV Tat peptide contains full activity; auxiliary amino acids exist in N terminal 17/34 aa region; Cys rich region and basic region are essential to BIV Tat activity. Computer prediction of BIV Tat secondary structure was showed, and mechanism how it functions was analyzed. | 荣丽玮 王世珍 刘淑红 陈启民 耿运琪 C.Wood | 2000 | 中国病毒学2000，15，1： | 0 |
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